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E8V8U3

- E8V8U3_TERSS

UniProt

E8V8U3 - E8V8U3_TERSS

Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Terriglobus saanensis (strain ATCC BAA-1853 / DSM 23119 / SP1PR4)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Diphosphate + H2O = 2 phosphate.UniRule annotation

    Cofactori

    Binds 4 magnesium ions per subunit. Other metal ions can support activity, but at a lower rate. Two magnesium ions are required for the activation of the enzyme and are present before substrate binds, two additional magnesium ions form complexes with substrate and product.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi66 – 661Magnesium 1UniRule annotation
    Metal bindingi71 – 711Magnesium 1UniRule annotation
    Metal bindingi71 – 711Magnesium 2UniRule annotation
    Metal bindingi103 – 1031Magnesium 1UniRule annotation

    GO - Molecular functioni

    1. inorganic diphosphatase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. phosphate-containing compound metabolic process Source: InterPro

    Keywords - Molecular functioni

    HydrolaseUniRule annotationImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciTSAA401053:GHYY-3418-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
    Alternative name(s):
    Pyrophosphate phospho-hydrolaseUniRule annotation
    Gene namesi
    Name:ppaUniRule annotation
    Ordered Locus Names:AciPR4_3376Imported
    OrganismiTerriglobus saanensis (strain ATCC BAA-1853 / DSM 23119 / SP1PR4)Imported
    Taxonomic identifieri401053 [NCBI]
    Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeTerriglobus
    ProteomesiUP000006844: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000236472.
    KOiK01507.

    Family and domain databases

    Gene3Di3.90.80.10. 1 hit.
    HAMAPiMF_00209. Inorganic_PPase.
    InterProiIPR008162. Pyrophosphatase.
    [Graphical view]
    PANTHERiPTHR10286. PTHR10286. 1 hit.
    PfamiPF00719. Pyrophosphatase. 1 hit.
    [Graphical view]
    SUPFAMiSSF50324. SSF50324. 1 hit.
    PROSITEiPS00387. PPASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E8V8U3-1 [UniParc]FASTAAdd to Basket

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    MPNYLELPVG SKAPHEVNVV IEIPLDGVTK FEYDKQLHVF RLDRNLYSPV    50
    HYPGDYGFIP STLGDDGDPL DVLVLVDTPS FPGCVQSVRP IGLMEMIDNG 100
    EGDEKVLAVG CANPRYFDVN SYEQIHPHKL KEIIHFFSTY KDLEGKKVEI 150
    KGWRDTAYAH EVIKKSMAAF KNGTKI 176
    Length:176
    Mass (Da):19,837
    Last modified:April 5, 2011 - v1
    Checksum:iD88858073830F3F3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002467 Genomic DNA. Translation: ADV84130.1.
    RefSeqiYP_004184124.1. NC_014963.1.

    Genome annotation databases

    EnsemblBacteriaiADV84130; ADV84130; AciPR4_3376.
    GeneIDi10161308.
    KEGGitsa:AciPR4_3376.
    PATRICi46832646. VBITerSaa54836_3502.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002467 Genomic DNA. Translation: ADV84130.1 .
    RefSeqi YP_004184124.1. NC_014963.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADV84130 ; ADV84130 ; AciPR4_3376 .
    GeneIDi 10161308.
    KEGGi tsa:AciPR4_3376.
    PATRICi 46832646. VBITerSaa54836_3502.

    Phylogenomic databases

    HOGENOMi HOG000236472.
    KOi K01507.

    Enzyme and pathway databases

    BioCyci TSAA401053:GHYY-3418-MONOMER.

    Family and domain databases

    Gene3Di 3.90.80.10. 1 hit.
    HAMAPi MF_00209. Inorganic_PPase.
    InterProi IPR008162. Pyrophosphatase.
    [Graphical view ]
    PANTHERi PTHR10286. PTHR10286. 1 hit.
    Pfami PF00719. Pyrophosphatase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50324. SSF50324. 1 hit.
    PROSITEi PS00387. PPASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Terriglobus saanensis type strain SP1PR4(T), an Acidobacteria from tundra soil."
      Rawat S.R., Mannisto M.K., Starovoytov V., Goodwin L., Nolan M., Hauser L., Land M., Davenport K.W., Woyke T., Haggblom M.M.
      Stand. Genomic Sci. 7:59-69(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ATCC BAA-1853 / DSM 23119 / SP1PR4Imported.

    Entry informationi

    Entry nameiE8V8U3_TERSS
    AccessioniPrimary (citable) accession number: E8V8U3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3