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Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Terriglobus saanensis (strain ATCC BAA-1853 / DSM 23119 / SP1PR4)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.UniRule annotation

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei30SubstrateUniRule annotation1
Binding sitei44SubstrateUniRule annotation1
Binding sitei56SubstrateUniRule annotation1
Metal bindingi66Magnesium 1UniRule annotation1
Metal bindingi71Magnesium 1UniRule annotation1
Metal bindingi71Magnesium 2UniRule annotation1
Metal bindingi103Magnesium 1UniRule annotation1
Binding sitei140SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Gene namesi
Name:ppaUniRule annotation
Ordered Locus Names:AciPR4_3376Imported
OrganismiTerriglobus saanensis (strain ATCC BAA-1853 / DSM 23119 / SP1PR4)Imported
Taxonomic identifieri401053 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeTerriglobus
Proteomesi
  • UP000006844 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi401053.AciPR4_3376.

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F0N. Bacteria.
COG0221. LUCA.
HOGENOMiHOG000236472.
KOiK01507.
OMAiPVDYGII.
OrthoDBiPOG091H05Q5.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8V8U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNYLELPVG SKAPHEVNVV IEIPLDGVTK FEYDKQLHVF RLDRNLYSPV
60 70 80 90 100
HYPGDYGFIP STLGDDGDPL DVLVLVDTPS FPGCVQSVRP IGLMEMIDNG
110 120 130 140 150
EGDEKVLAVG CANPRYFDVN SYEQIHPHKL KEIIHFFSTY KDLEGKKVEI
160 170
KGWRDTAYAH EVIKKSMAAF KNGTKI
Length:176
Mass (Da):19,837
Last modified:April 5, 2011 - v1
Checksum:iD88858073830F3F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002467 Genomic DNA. Translation: ADV84130.1.
RefSeqiWP_013569861.1. NC_014963.1.

Genome annotation databases

EnsemblBacteriaiADV84130; ADV84130; AciPR4_3376.
KEGGitsa:AciPR4_3376.
PATRICi46832646. VBITerSaa54836_3502.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002467 Genomic DNA. Translation: ADV84130.1.
RefSeqiWP_013569861.1. NC_014963.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi401053.AciPR4_3376.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADV84130; ADV84130; AciPR4_3376.
KEGGitsa:AciPR4_3376.
PATRICi46832646. VBITerSaa54836_3502.

Phylogenomic databases

eggNOGiENOG4105F0N. Bacteria.
COG0221. LUCA.
HOGENOMiHOG000236472.
KOiK01507.
OMAiPVDYGII.
OrthoDBiPOG091H05Q5.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE8V8U3_TERSS
AccessioniPrimary (citable) accession number: E8V8U3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 2, 2016
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.