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Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Terriglobus saanensis (strain ATCC BAA-1853 / DSM 23119 / SP1PR4)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 4 Mg(2+) ions per subunit. Other metal ions can support activity, but at a lower rate. Two Mg(2+) ions are required for the activation of the enzyme and are present before substrate binds, two additional Mg2+ ions form complexes with substrate and product.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi66 – 661Magnesium 1UniRule annotation
Metal bindingi71 – 711Magnesium 1UniRule annotation
Metal bindingi71 – 711Magnesium 2UniRule annotation
Metal bindingi103 – 1031Magnesium 1UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciTSAA401053:GHYY-3418-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Gene namesi
Name:ppaUniRule annotation
Ordered Locus Names:AciPR4_3376Imported
OrganismiTerriglobus saanensis (strain ATCC BAA-1853 / DSM 23119 / SP1PR4)Imported
Taxonomic identifieri401053 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeTerriglobus
ProteomesiUP000006844 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi401053.AciPR4_3376.

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000236472.
KOiK01507.
OMAiPVALMKM.

Family and domain databases

Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8V8U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNYLELPVG SKAPHEVNVV IEIPLDGVTK FEYDKQLHVF RLDRNLYSPV
60 70 80 90 100
HYPGDYGFIP STLGDDGDPL DVLVLVDTPS FPGCVQSVRP IGLMEMIDNG
110 120 130 140 150
EGDEKVLAVG CANPRYFDVN SYEQIHPHKL KEIIHFFSTY KDLEGKKVEI
160 170
KGWRDTAYAH EVIKKSMAAF KNGTKI
Length:176
Mass (Da):19,837
Last modified:April 5, 2011 - v1
Checksum:iD88858073830F3F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002467 Genomic DNA. Translation: ADV84130.1.
RefSeqiWP_013569861.1. NC_014963.1.
YP_004184124.1. NC_014963.1.

Genome annotation databases

EnsemblBacteriaiADV84130; ADV84130; AciPR4_3376.
KEGGitsa:AciPR4_3376.
PATRICi46832646. VBITerSaa54836_3502.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002467 Genomic DNA. Translation: ADV84130.1.
RefSeqiWP_013569861.1. NC_014963.1.
YP_004184124.1. NC_014963.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi401053.AciPR4_3376.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADV84130; ADV84130; AciPR4_3376.
KEGGitsa:AciPR4_3376.
PATRICi46832646. VBITerSaa54836_3502.

Phylogenomic databases

HOGENOMiHOG000236472.
KOiK01507.
OMAiPVALMKM.

Enzyme and pathway databases

BioCyciTSAA401053:GHYY-3418-MONOMER.

Family and domain databases

Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Terriglobus saanensis type strain SP1PR4(T), an Acidobacteria from tundra soil."
    Rawat S.R., Mannisto M.K., Starovoytov V., Goodwin L., Nolan M., Hauser L., Land M., Davenport K.W., Woyke T., Haggblom M.M.
    Stand. Genomic Sci. 7:59-69(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC BAA-1853 / DSM 23119 / SP1PR4Imported.

Entry informationi

Entry nameiE8V8U3_TERSS
AccessioniPrimary (citable) accession number: E8V8U3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 24, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.