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Protein

50S ribosomal protein L1

Gene

rplA

Organism
Thermoanaerobacter brockii subsp. finnii (strain ATCC 43586 / DSM 3389 / AKO-1) (Thermoanaerobacter finnii)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.UniRule annotation
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.UniRule annotation

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro
  3. tRNA binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of translation Source: UniProtKB-KW
  2. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

RepressorUniRule annotation, Ribonucleoprotein, Ribosomal proteinUniRule annotationImported

Keywords - Biological processi

Translation regulationUniRule annotation

Keywords - Ligandi

RNA-binding, rRNA-bindingUniRule annotation, tRNA-bindingUniRule annotation

Enzyme and pathway databases

BioCyciTBRO509193:GHWP-381-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L1UniRule annotation
Gene namesi
Name:rplAUniRule annotation
Ordered Locus Names:Thebr_0373Imported
OrganismiThermoanaerobacter brockii subsp. finnii (strain ATCC 43586 / DSM 3389 / AKO-1) (Thermoanaerobacter finnii)Imported
Taxonomic identifieri509193 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
ProteomesiUP000002062 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. large ribosomal subunit Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit.UniRule annotation

Structurei

3D structure databases

SMRiE8UUX3. Positions 5-227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L1P family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000207015.
KOiK02863.

Family and domain databases

Gene3Di3.30.190.20. 2 hits.
3.40.50.790. 1 hit.
HAMAPiMF_01318_B. Ribosomal_L1_B.
InterProiIPR005878. Ribosom_L1_bac-type.
IPR002143. Ribosomal_L1.
IPR023674. Ribosomal_L1-like.
IPR028364. Ribosomal_L1/biogenesis.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR023673. Ribosomal_L1_CS.
[Graphical view]
PfamiPF00687. Ribosomal_L1. 1 hit.
[Graphical view]
PIRSFiPIRSF002155. Ribosomal_L1. 1 hit.
SUPFAMiSSF56808. SSF56808. 1 hit.
TIGRFAMsiTIGR01169. rplA_bact. 1 hit.
PROSITEiPS01199. RIBOSOMAL_L1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8UUX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRGKKYLES LKLYDKTQQY SSDEAIDIVL KTAKANFDET IDLAVRLGVD
60 70 80 90 100
PRHADQQVRG TVVLPHGTGK SVKVLVFAKG EKAKEAEAAG ADYVGAEELV
110 120 130 140 150
AKIQNENWFD YDVVVATPDM MGAVGRLGKI LGPKGLMPNP KSGTVTFDLE
160 170 180 190 200
KAIKEIKAGK IEYRVDKAGI IHVPIGKKSF GKEKLLENFR AVMDAIIKSK
210 220 230
PAAAKGQYIK SLVLSSTMGP GVKVNPLKIF
Length:230
Mass (Da):25,014
Last modified:April 4, 2011 - v1
Checksum:iAC36EA5538912ECC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002466 Genomic DNA. Translation: ADV78988.1.
RefSeqiYP_004185371.1. NC_014964.1.

Genome annotation databases

EnsemblBacteriaiADV78988; ADV78988; Thebr_0373.
KEGGitbo:Thebr_0373.
PATRICi47038637. VBITheBro57020_0392.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002466 Genomic DNA. Translation: ADV78988.1.
RefSeqiYP_004185371.1. NC_014964.1.

3D structure databases

SMRiE8UUX3. Positions 5-227.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADV78988; ADV78988; Thebr_0373.
KEGGitbo:Thebr_0373.
PATRICi47038637. VBITheBro57020_0392.

Phylogenomic databases

HOGENOMiHOG000207015.
KOiK02863.

Enzyme and pathway databases

BioCyciTBRO509193:GHWP-381-MONOMER.

Family and domain databases

Gene3Di3.30.190.20. 2 hits.
3.40.50.790. 1 hit.
HAMAPiMF_01318_B. Ribosomal_L1_B.
InterProiIPR005878. Ribosom_L1_bac-type.
IPR002143. Ribosomal_L1.
IPR023674. Ribosomal_L1-like.
IPR028364. Ribosomal_L1/biogenesis.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR023673. Ribosomal_L1_CS.
[Graphical view]
PfamiPF00687. Ribosomal_L1. 1 hit.
[Graphical view]
PIRSFiPIRSF002155. Ribosomal_L1. 1 hit.
SUPFAMiSSF56808. SSF56808. 1 hit.
TIGRFAMsiTIGR01169. rplA_bact. 1 hit.
PROSITEiPS01199. RIBOSOMAL_L1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Thermoanaerobacter brockii finnii Ako-1."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Chertkov O., Munk C., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mikhailova N., Pagani I., Hemme C.L., Woyke T.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43586 / DSM 3389 / AKO-1Imported.

Entry informationi

Entry nameiE8UUX3_THEBF
AccessioniPrimary (citable) accession number: E8UUX3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 4, 2011
Last sequence update: April 4, 2011
Last modified: March 31, 2015
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.