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E8UU11 (E8UU11_THEBF) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain141 – 346206ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding172 – 22756ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2991Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3131Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3131Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3151Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
E8UU11 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: A8646128A86188AE

FASTA35940,083
        10         20         30         40         50         60 
MEKKKIAVLF GGQSGEHEVS LMSAKSIINN LDKDKYEIYM VGITKKGEWY LYRGDVGKIE 

        70         80         90        100        110        120 
TGEWEKEGIP AIMGASTKYR GIITFEDGEN GFYPIDVVFP VLHGPNGEDG TIQGLLELLD 

       130        140        150        160        170        180 
MPYVGANVLS SALCMDKVFT KRIFKEAGLP TPDFVVVYGK EIEDLEAIKK KIEHLGYPCF 

       190        200        210        220        230        240 
VKPANLGSSV GITKVHNEEE LPGALKLAAK YDRKLLIERG IDAREIECSV LGNENPEASI 

       250        260        270        280        290        300 
AGEIVPSNEF YDYNAKYFDG GKSLLLIPAP LPDEKMEEVR KLAIKAYKAL DLRGMARVDF 

       310        320        330        340        350 
LMDRNTGTLY LNEVNTIPGF TKISMYPKLW ESSGKSYSTL LDELINLAVE SHNEKCREW 

« Hide

References

[1]"Complete sequence of Thermoanaerobacter brockii finnii Ako-1."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Chertkov O., Munk C., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mikhailova N., Pagani I., Hemme C.L., Woyke T.
Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43586 / DSM 3389 / AKO-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002466 Genomic DNA. Translation: ADV78821.1.
RefSeqYP_004185204.1. NC_014964.1.

3D structure databases

ProteinModelPortalE8UU11.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADV78821; ADV78821; Thebr_0193.
GeneID10162422.
KEGGtbo:Thebr_0193.
PATRIC47038252. VBITheBro57020_0207.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011593.
KOK01921.

Enzyme and pathway databases

BioCycTBRO509193:GHWP-196-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE8UU11_THEBF
AccessionPrimary (citable) accession number: E8UU11
Entry history
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: February 19, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)