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E8UQY4

- E8UQY4_THEBF

UniProt

E8UQY4 - E8UQY4_THEBF

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Protein
Probable glycine dehydrogenase [decarboxylating] subunit 1
Gene
gcvPA, Thebr_2038
Organism
Thermoanaerobacter brockii subsp. finnii (strain ATCC 43586 / DSM 3389 / AKO-1) (Thermoanaerobacter finnii)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotationSAAS annotations

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotationsImported

Enzyme and pathway databases

BioCyciTBRO509193:GHWP-2096-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase [decarboxylating] subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Thebr_2038Imported
OrganismiThermoanaerobacter brockii subsp. finnii (strain ATCC 43586 / DSM 3389 / AKO-1) (Thermoanaerobacter finnii)Imported
Taxonomic identifieri509193 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
ProteomesiUP000002062: Chromosome

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.UniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliE8UQY4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000132025.
KOiK00282.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

E8UQY4-1 [UniParc]FASTAAdd to Basket

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MFPYLPASSN DEKEMLKTIG KNSIEELFEN IPQEVRLKRP LNLGSPMSEV    50
ELTAHIKKYA KENKSLEELT SFLGAGVYDH YIPSVVKHII SRSEFYTAYT 100
PYQPEISQGT LQAIFEYQTM ITNLTGMEVT NASMYDGATA CAEAAIMACE 150
NTKRKTILVS KTVNPETRKV LKTYMHFRDI QVIEIDDNEG VTDLEKLKAE 200
IGTNTAAVIV QYPNFFGIIE DLQEIEKITH ENKAMLITYV HPIPLGVLKS 250
PGEIGADITV GDGQSLGNGL NFGGPYLGFL ATMQKLVRKM PGRIVGQTKD 300
VDGKRAFVLT LQAREQHIRR EKATSNICSN HSLNALTAAV YLATMGKKGI 350
KEVAYQCTQK AHYAFSVLTA SGKYKPAFNK PFFMEFALKT DVNVDLINKK 400
LLEKGILGGY NLHRDYDKYE NTMLLAFTEK RTKEEIDELK ALLEVIV 447
Length:447
Mass (Da):50,064
Last modified:April 5, 2011 - v1
Checksum:i1CCAE3993BB31B7A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002466 Genomic DNA. Translation: ADV80554.1.
RefSeqiYP_004186937.1. NC_014964.1.

Genome annotation databases

EnsemblBacteriaiADV80554; ADV80554; Thebr_2038.
GeneIDi10164321.
KEGGitbo:Thebr_2038.
PATRICi47042175. VBITheBro57020_2100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002466 Genomic DNA. Translation: ADV80554.1 .
RefSeqi YP_004186937.1. NC_014964.1.

3D structure databases

ProteinModelPortali E8UQY4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADV80554 ; ADV80554 ; Thebr_2038 .
GeneIDi 10164321.
KEGGi tbo:Thebr_2038.
PATRICi 47042175. VBITheBro57020_2100.

Phylogenomic databases

HOGENOMi HOG000132025.
KOi K00282.

Enzyme and pathway databases

BioCyci TBRO509193:GHWP-2096-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Thermoanaerobacter brockii finnii Ako-1."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Chertkov O., Munk C., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mikhailova N., Pagani I., Hemme C.L., Woyke T.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43586 / DSM 3389 / AKO-1.

Entry informationi

Entry nameiE8UQY4_THEBF
AccessioniPrimary (citable) accession number: E8UQY4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 3, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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