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E8UQY4

- E8UQY4_THEBF

UniProt

E8UQY4 - E8UQY4_THEBF

Protein

Probable glycine dehydrogenase [decarboxylating] subunit 1

Gene

gcvPA

Organism
Thermoanaerobacter brockii subsp. finnii (strain ATCC 43586 / DSM 3389 / AKO-1) (Thermoanaerobacter finnii)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotationSAAS annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro
    2. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotationImported

    Enzyme and pathway databases

    BioCyciTBRO509193:GHWP-2096-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase [decarboxylating] subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 1UniRule annotation
    Glycine decarboxylase subunit 1UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
    Gene namesi
    Name:gcvPAUniRule annotation
    Ordered Locus Names:Thebr_2038Imported
    OrganismiThermoanaerobacter brockii subsp. finnii (strain ATCC 43586 / DSM 3389 / AKO-1) (Thermoanaerobacter finnii)Imported
    Taxonomic identifieri509193 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
    ProteomesiUP000002062: Chromosome

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE8UQY4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000132025.
    KOiK00282.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00712. GcvPA.
    InterProiIPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006815. GcvPA. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E8UQY4-1 [UniParc]FASTAAdd to Basket

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    MFPYLPASSN DEKEMLKTIG KNSIEELFEN IPQEVRLKRP LNLGSPMSEV    50
    ELTAHIKKYA KENKSLEELT SFLGAGVYDH YIPSVVKHII SRSEFYTAYT 100
    PYQPEISQGT LQAIFEYQTM ITNLTGMEVT NASMYDGATA CAEAAIMACE 150
    NTKRKTILVS KTVNPETRKV LKTYMHFRDI QVIEIDDNEG VTDLEKLKAE 200
    IGTNTAAVIV QYPNFFGIIE DLQEIEKITH ENKAMLITYV HPIPLGVLKS 250
    PGEIGADITV GDGQSLGNGL NFGGPYLGFL ATMQKLVRKM PGRIVGQTKD 300
    VDGKRAFVLT LQAREQHIRR EKATSNICSN HSLNALTAAV YLATMGKKGI 350
    KEVAYQCTQK AHYAFSVLTA SGKYKPAFNK PFFMEFALKT DVNVDLINKK 400
    LLEKGILGGY NLHRDYDKYE NTMLLAFTEK RTKEEIDELK ALLEVIV 447
    Length:447
    Mass (Da):50,064
    Last modified:April 5, 2011 - v1
    Checksum:i1CCAE3993BB31B7A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002466 Genomic DNA. Translation: ADV80554.1.
    RefSeqiYP_004186937.1. NC_014964.1.

    Genome annotation databases

    EnsemblBacteriaiADV80554; ADV80554; Thebr_2038.
    GeneIDi10164321.
    KEGGitbo:Thebr_2038.
    PATRICi47042175. VBITheBro57020_2100.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002466 Genomic DNA. Translation: ADV80554.1 .
    RefSeqi YP_004186937.1. NC_014964.1.

    3D structure databases

    ProteinModelPortali E8UQY4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADV80554 ; ADV80554 ; Thebr_2038 .
    GeneIDi 10164321.
    KEGGi tbo:Thebr_2038.
    PATRICi 47042175. VBITheBro57020_2100.

    Phylogenomic databases

    HOGENOMi HOG000132025.
    KOi K00282.

    Enzyme and pathway databases

    BioCyci TBRO509193:GHWP-2096-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00712. GcvPA.
    InterProi IPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006815. GcvPA. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Thermoanaerobacter brockii finnii Ako-1."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Chertkov O., Munk C., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mikhailova N., Pagani I., Hemme C.L., Woyke T.
      Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43586 / DSM 3389 / AKO-1Imported.

    Entry informationi

    Entry nameiE8UQY4_THEBF
    AccessioniPrimary (citable) accession number: E8UQY4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3