E8UQY4 (E8UQY4_THEBF) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP-Rule MF_00712
EC=1.4.4.2 HAMAP-Rule MF_00712

Alternative name(s):
Glycine cleavage system P-protein subunit 1 HAMAP-Rule MF_00712
Glycine decarboxylase subunit 1 HAMAP-Rule MF_00712

Gene names

Name:	gcvPA HAMAP-Rule MF_00712
Ordered Locus Names:	Thebr_2038

Organism

Thermoanaerobacter brockii subsp. finnii (strain ATCC 43586 / DSM 3389 / AKO-1) (Thermoanaerobacter finnii) [Complete proteome] [HAMAP] EMBL ADV80554.1

Taxonomic identifier

509193 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteraceae › Thermoanaerobacter › Thermoanaerobacter brockii › Thermoanaerobacter brockii subsp. finnii

Protein attributes

Sequence length	447 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712 SAAS SAAS023010
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP-Rule MF_00712 SAAS SAAS023010
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity. HAMAP-Rule MF_00712 SAAS SAAS023010
Sequence similarities	Belongs to the GcvP family. N-terminal subunit subfamily. HAMAP-Rule MF_00712

Ontologies

Keywords
Molecular function	Oxidoreductase HAMAP-Rule MF_00712 SAAS SAAS023010 EMBL ADV80554.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP nucleoside metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E8UQY4 [UniParc]. Last modified April 5, 2011. Version 1. Checksum: 1CCAE3993BB31B7A	FASTA	447	50,064
	10 20 30 40 50 60 MFPYLPASSN DEKEMLKTIG KNSIEELFEN IPQEVRLKRP LNLGSPMSEV ELTAHIKKYA 70 80 90 100 110 120 KENKSLEELT SFLGAGVYDH YIPSVVKHII SRSEFYTAYT PYQPEISQGT LQAIFEYQTM 130 140 150 160 170 180 ITNLTGMEVT NASMYDGATA CAEAAIMACE NTKRKTILVS KTVNPETRKV LKTYMHFRDI 190 200 210 220 230 240 QVIEIDDNEG VTDLEKLKAE IGTNTAAVIV QYPNFFGIIE DLQEIEKITH ENKAMLITYV 250 260 270 280 290 300 HPIPLGVLKS PGEIGADITV GDGQSLGNGL NFGGPYLGFL ATMQKLVRKM PGRIVGQTKD 310 320 330 340 350 360 VDGKRAFVLT LQAREQHIRR EKATSNICSN HSLNALTAAV YLATMGKKGI KEVAYQCTQK 370 380 390 400 410 420 AHYAFSVLTA SGKYKPAFNK PFFMEFALKT DVNVDLINKK LLEKGILGGY NLHRDYDKYE 430 440 NTMLLAFTEK RTKEEIDELK ALLEVIV

References

[1]

"Complete sequence of Thermoanaerobacter brockii finnii Ako-1." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Chertkov O., Munk C., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mikhailova N., Pagani I., Hemme C.L., Woyke T. Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43586 / DSM 3389 / AKO-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002466 Genomic DNA. Translation: ADV80554.1.
RefSeq	YP_004186937.1. NC_014964.1.
3D structure databases
ProteinModelPortal	E8UQY4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADV80554; ADV80554; Thebr_2038.
GeneID	10164321.
KEGG	tbo:Thebr_2038.
PATRIC	47042175. VBITheBro57020_2100.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000132025.
KO	K00282.
Family and domain databases
Gene3D	3.40.640.10. 1 hit.
HAMAP	MF_00712. GcvPA.
InterPro	IPR020580. GDC-P_N. IPR020581. GDC_P. IPR023010. GDC_P_su1. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
PANTHER	PTHR11773. PTHR11773. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
PIRSF	PIRSF006815. GcvPA. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

E8UQY4_THEBF

Accession

Primary (citable) accession number: E8UQY4

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	May 1, 2013
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)