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E8ULT6 (E8ULT6_STREJ) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddlA EMBL ADV70381.1
Synonyms:ddl HAMAP-Rule MF_00047
Ordered Locus Names:SSUJS14_1314 EMBL ADV70381.1
OrganismStreptococcus suis (strain JS14) [Complete proteome] [HAMAP] EMBL ADV70381.1
Taxonomic identifier945704 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain132 – 334203ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding162 – 21756ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2881Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3011Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3011Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3031Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
E8ULT6 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: B592A7E9F0E10C4A

FASTA34838,806
        10         20         30         40         50         60 
MSKETLILLY GGRSAEREVS VLSAESVMRA INYDKFFVKT YFISQTGDFI KTQEFSQTPS 

        70         80         90        100        110        120 
ADEKLMTNAT IVEEQKIRPS DIYEEKAVVF PVLHGPMGED GSIQGFLEVL RMPYVGTNIL 

       130        140        150        160        170        180 
SSSVAMDKIT TKRVLESAGI SQVPYVAVIE GENIDDKIAE IEGKLTYPVF VKPANMGSSV 

       190        200        210        220        230        240 
GISKAEDLAG LRKALDLAFK YDSRVLVEQG VNAREIEVGL LGNADVKTTL PGEVVKDVAF 

       250        260        270        280        290        300 
YDYDAKYIDN KITMEIPAKI DESIMDIMRD NAAKAFRAIG GCGLSRCDFF LTEDGDIFLN 

       310        320        330        340 
ELNTMPGFTQ WSMYPLLWDN MGLAYPDLIE ELVRLAKEMF EKRESHLI 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Streptococcus suis serotype 14 strain JS14."
Hu P., Yang M., Zhang A., Wu J., Chen B., Hua Y., Yu J., Xiao J., Jin M.
J. Bacteriol. 193:2375-2376(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JS14 EMBL ADV70381.1.
[2]Hu P., Yang M., Jin M., Xiao J.
Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: JS14.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002465 Genomic DNA. Translation: ADV70381.1.
RefSeqYP_006076652.1. NC_017618.1.

3D structure databases

ProteinModelPortalE8ULT6.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADV70381; ADV70381; SSUJS14_1314.
GeneID12722529.
KEGGsui:SSUJS14_1314.
PATRIC45415129. VBIStrSui181850_1279.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OMAKLAFQYD.

Enzyme and pathway databases

BioCycSSUI945704:GLLM-1352-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE8ULT6_STREJ
AccessionPrimary (citable) accession number: E8ULT6
Entry history
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 11, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)