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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Taylorella equigenitalis (strain MCE9)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei9Tele-phosphohistidine intermediateUniRule annotation1
Binding sitei60SubstrateUniRule annotation1
Active sitei87Proton donor/acceptorUniRule annotation1
Binding sitei98SubstrateUniRule annotation1
Sitei182Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
Biological processGluconeogenesisUniRule annotation, GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAMUniRule annotation
Short name:
PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
dPGMUniRule annotation
Gene namesi
Name:gpmAUniRule annotation
Ordered Locus Names:TEQUI_0744Imported
OrganismiTaylorella equigenitalis (strain MCE9)Imported
Taxonomic identifieri937774 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeTaylorella
Proteomesi
  • UP000007472 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi937774.TEQUI_0744

Structurei

3D structure databases

ProteinModelPortaliE8UFR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni8 – 15Substrate bindingUniRule annotation8
Regioni21 – 22Substrate bindingUniRule annotation2
Regioni87 – 90Substrate bindingUniRule annotation4
Regioni114 – 115Substrate bindingUniRule annotation2
Regioni183 – 184Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DKJ Bacteria
COG0588 LUCA
HOGENOMiHOG000221682
KOiK01834
OMAiRMLPYWY
OrthoDBiPOG091H03E2

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
HAMAPiMF_01039 PGAM_GpmA, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR001345 PG/BPGM_mutase_AS
IPR005952 Phosphogly_mut1
PANTHERiPTHR11931 PTHR11931, 1 hit
PfamiView protein in Pfam
PF00300 His_Phos_1, 1 hit
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
TIGRFAMsiTIGR01258 pgm_1, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit

Sequencei

Sequence statusi: Complete.

E8UFR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKLVLMRHG ESQWNLENRF TGWADVDLTD TGRKQAKEAG ALLKEQGFDF
60 70 80 90 100
DIAYTSVLKR AIRTLWIALD EMDRMHLPVM KSWRLNERHY GNLQGLNKSE
110 120 130 140 150
TAQKFGDEQV LIWRRAYAIA PDPISNDDER HPRFDARYKD LDQSELPSTE
160 170 180 190 200
CLKDTVARVI PLWEEQISKD IKEGKRVLIT AHGNSLRALI KHLDQISDDD
210 220 230 240
IVSLNIPTGQ PLVYELDENL KPIKHYYIGD QEAIAKAVAA VAAQGKAK
Length:248
Mass (Da):28,396
Last modified:April 5, 2011 - v1
Checksum:iF0D9CB15B20A7A3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002456 Genomic DNA Translation: ADU91682.1
RefSeqiWP_013521917.1, NC_014914.1

Genome annotation databases

EnsemblBacteriaiADU91682; ADU91682; TEQUI_0744
GeneIDi34293562
KEGGiteq:TEQUI_0744

Similar proteinsi

Entry informationi

Entry nameiE8UFR8_TAYEM
AccessioniPrimary (citable) accession number: E8UFR8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 28, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health