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E8UEF6 (E8UEF6_TAYEM) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:TEQUI_0305 EMBL ADU91252.1
OrganismTaylorella equigenitalis (strain MCE9) [Complete proteome] [HAMAP] EMBL ADU91252.1
Taxonomic identifier937774 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeTaylorella

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain101 – 300200ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding127 – 18256ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2541Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2671Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2671Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2691Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
E8UEF6 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: EA1F0D31FD3841A0

FASTA31234,749
        10         20         30         40         50         60 
MDKSLKIAVL YGGNSAEREV SLMSGQGVGN ALKSRGYNIE LFDIANRDLL ELKNFDLAFI 

        70         80         90        100        110        120 
ALHGKYGEDG CIQGFLELLK IPYTGPGVMS SSVGMNKIVS KKIFIHEGIP TPEFRVVRDY 

       130        140        150        160        170        180 
EGLEKATQEI GYPIIVKPPQ EGSTIGLKKV HSQDELTEAF NESIKFDEEM LVEKCIEGRE 

       190        200        210        220        230        240 
LTVAIIGKSP DTRALPIIEI VTPDGNYDYE QKYTRDDTQY ICPAKLDENL ARNIENICIK 

       250        260        270        280        290        300 
AYDSLECQGW SRVDVMLDKN NCPWVLEINT SPGMTSHSLV PMAAKAIGLS YEDICEEILK 

       310 
TACLKVKKLN KV 

« Hide

References

[1]"Genome sequence of Taylorella equigenitalis MCE9, the causative agent of contagious equine metritis."
Hebert L., Moumen B., Duquesne F., Breuil M.F., Laugier C., Batto J.M., Renault P., Petry S.
J. Bacteriol. 193:1785-1785(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MCE9 EMBL ADU91252.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002456 Genomic DNA. Translation: ADU91252.1.
RefSeqYP_004129395.1. NC_014914.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADU91252; ADU91252; TEQUI_0305.
GeneID10114140.
KEGGteq:TEQUI_0305.
PATRIC45374531. VBITayEqu178523_0293.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011592.
KOK01921.
OMADTQYRIP.

Enzyme and pathway databases

BioCycTEQU937774:GHXS-305-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE8UEF6_TAYEM
AccessionPrimary (citable) accession number: E8UEF6
Entry history
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: February 19, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)