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Protein

Alanine racemase

Gene

TEQUI_1568

Organism
Taylorella equigenitalis (strain MCE9)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathway: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (TEQUI_1325), Alanine racemase (TEQUI_1568)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei74 – 741Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei173 – 1731SubstrateUniRule annotation
Active sitei300 – 3001Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei348 – 3481Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciTEQU937774:GHXS-1568-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:TEQUI_1568Imported
OrganismiTaylorella equigenitalis (strain MCE9)Imported
Taxonomic identifieri937774 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeTaylorella
ProteomesiUP000007472 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei74 – 741N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi937774.TEQUI_1568.

Structurei

3D structure databases

ProteinModelPortaliE8UEB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000279190.
KOiK01775.
OMAiNTVMVDV.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8UEB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYPLKSLTI VIASLFAAQS NSAPVLSTDD VKVSQLSELS ANAWIEVDVQ
60 70 80 90 100
AFENNIAELQ KLLNGKSKVC AILKADAYGH GINLLMPSII KMNVPCIGIA
110 120 130 140 150
SNEEARIARA HNYEGTIMRV RAASINEIKD GLKYDMEELV GDVTQAQTIN
160 170 180 190 200
ALAKEAGKDV RIHISLNSAG MDRNGIDMST DNGRAEALEL TKFSNLKVVG
210 220 230 240 250
IMTHYPEENE EIIRKDLVRF NEDSKWLIEN AGLNRNQIVI HTANSYTTLT
260 270 280 290 300
VPEAHFDMVR PGGLLYGDSI PTRTEYKRIL SFKSRVANIN HYPKGSTVGY
310 320 330 340 350
DRTFKLERDS MLANLPFGYS DGYRRIFSNK GYVLINGHKV PVVGRVSMNT
360 370 380 390 400
TMVDVTDFPD ILEGAEVVIF GTQGDAKVEQ ADIEEINGAL LADLYTVWGN
410
SNPRIAKPTT TN
Length:412
Mass (Da):45,487
Last modified:April 5, 2011 - v1
Checksum:i7338E2A688B3FC65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002456 Genomic DNA. Translation: ADU92480.1.
RefSeqiWP_013522715.1. NC_014914.1.
YP_004130623.1. NC_014914.1.

Genome annotation databases

EnsemblBacteriaiADU92480; ADU92480; TEQUI_1568.
KEGGiteq:TEQUI_1568.
PATRICi45377042. VBITayEqu178523_1512.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002456 Genomic DNA. Translation: ADU92480.1.
RefSeqiWP_013522715.1. NC_014914.1.
YP_004130623.1. NC_014914.1.

3D structure databases

ProteinModelPortaliE8UEB1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi937774.TEQUI_1568.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADU92480; ADU92480; TEQUI_1568.
KEGGiteq:TEQUI_1568.
PATRICi45377042. VBITayEqu178523_1512.

Phylogenomic databases

HOGENOMiHOG000279190.
KOiK01775.
OMAiNTVMVDV.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciTEQU937774:GHXS-1568-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Taylorella equigenitalis MCE9, the causative agent of contagious equine metritis."
    Hebert L., Moumen B., Duquesne F., Breuil M.F., Laugier C., Batto J.M., Renault P., Petry S.
    J. Bacteriol. 193:1785-1785(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MCE9Imported.

Entry informationi

Entry nameiE8UEB1_TAYEM
AccessioniPrimary (citable) accession number: E8UEB1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 24, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.