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E8U988

- E8U988_DEIML

UniProt

E8U988 - E8U988_DEIML

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Protein

Acetylornithine/acetyl-lysine aminotransferase

Gene

argD

Organism
Deinococcus maricopensis (strain DSM 21211 / LMG 22137 / NRRL B-23946 / LB-34)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in both the arginine and lysine biosynthetic pathways.UniRule annotation

Catalytic activityi

N(2)-acetyl-L-lysine + 2-oxoglutarate = N-acetyl-L-aminoadipate semialdehyde + L-glutamate.UniRule annotation
N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

Cofactori

Note: Binds 1 pyridoxal phosphate per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei160 – 1601Pyridoxal phosphate; via carbonyl oxygenUniRule annotation
Binding sitei163 – 1631N2-acetyl-L-ornithineUniRule annotation
Binding sitei326 – 3261N2-acetyl-L-ornithineUniRule annotation
Binding sitei327 – 3271Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
  2. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesisUniRule annotation, Lysine biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciDMAR709986:GHZG-2028-MONOMER.
UniPathwayiUPA00033; UER00038.
UPA00068; UER00109.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine/acetyl-lysine aminotransferaseUniRule annotation (EC:2.6.1.-UniRule annotation, EC:2.6.1.11UniRule annotation)
Short name:
ACOATUniRule annotation
Gene namesi
Name:argDUniRule annotation
Synonyms:lysJUniRule annotation
Ordered Locus Names:Deima_1982Imported
OrganismiDeinococcus maricopensis (strain DSM 21211 / LMG 22137 / NRRL B-23946 / LB-34)Imported
Taxonomic identifieri709986 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000008635: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei299 – 2991N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni269 – 2724Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000020206.
KOiK00823.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_01107. ArgD_aminotrans_3.
InterProiIPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8U988-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTATTARQPE LKTALPGPNT KAIMERDAKH LSTSYMRPYP FVPDRGEGVW
60 70 80 90 100
LTDVDGNTML DFFAGIAVST TGHAHPHVVQ AVQAQIERFA HVCLTDYPQE
110 120 130 140 150
ITTSLAERLV RHVERTLPDG RHEKWRVFLG NSGAEAVEAA VKLARNHTGR
160 170 180 190 200
SHIISTIGSF HGRTYGAITL TGSKTKYKRG FGPLLPNVSH VPYPNPFRPP
210 220 230 240 250
LGSTAETCGQ AVLNYLEDVL FQTVIPADEV AAIIVEPMQG EGGYIVPPAD
260 270 280 290 300
FLPGLRALCD RHGIMLIFDE VQAGMGRTGK MFSYQNFDGV QPDIITLAKG
310 320 330 340 350
IASGLPISAM MAKESVMTWP VGSHGSTFGG NPVAAAAAHA TLDLLEGAVK
360 370 380 390 400
HPGCGDNLMD NARTVGDYIL SELRDMQTEF PFLGDVRGQG LFIGLEFVKP
410 420 430 440 450
DGSPDGKLRD AASMAMFERG LLNLDCGESV IRISPPLILT REDAETGLNI

MRETLRSLQ
Length:459
Mass (Da):49,701
Last modified:April 5, 2011 - v1
Checksum:i053F3D31E4A07A8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002454 Genomic DNA. Translation: ADV67627.1.
RefSeqiYP_004171292.1. NC_014958.1.

Genome annotation databases

EnsemblBacteriaiADV67627; ADV67627; Deima_1982.
GeneIDi10151337.
KEGGidmr:Deima_1982.
PATRICi46925045. VBIDeiMar159729_1991.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002454 Genomic DNA. Translation: ADV67627.1 .
RefSeqi YP_004171292.1. NC_014958.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADV67627 ; ADV67627 ; Deima_1982 .
GeneIDi 10151337.
KEGGi dmr:Deima_1982.
PATRICi 46925045. VBIDeiMar159729_1991.

Phylogenomic databases

HOGENOMi HOG000020206.
KOi K00823.

Enzyme and pathway databases

UniPathwayi UPA00033 ; UER00038 .
UPA00068 ; UER00109 .
BioCyci DMAR709986:GHZG-2028-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_01107. ArgD_aminotrans_3.
InterProi IPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 21211 / LMG 22137 / NRRL B-23946 / LB-34Imported.

Entry informationi

Entry nameiE8U988_DEIML
AccessioniPrimary (citable) accession number: E8U988
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 26, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3