argD

Functionⁱ

Miscellaneous

May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.UniRule annotation

Catalytic activityⁱ

N₂-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

Pathwayⁱ: L-arginine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:

Arginine biosynthesis bifunctional protein ArgJ (argJ)
Acetylglutamate kinase (Deima_1346)
N-acetyl-gamma-glutamyl-phosphate reductase (argC), N-acetyl-gamma-glutamyl-phosphate reductase (argC)
Acetylornithine aminotransferase (argD), Acetylornithine aminotransferase (argD)

This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	160	Pyridoxal phosphate; via carbonyl oxygenUniRule annotation	1
Binding siteⁱ	163	N2-acetyl-L-ornithineUniRule annotation	1
Binding siteⁱ	326	N2-acetyl-L-ornithineUniRule annotation	1
Binding siteⁱ	327	Pyridoxal phosphateUniRule annotation	1

GO - Molecular functionⁱ

N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Source: UniProtKB-HAMAP
pyridoxal phosphate binding Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

arginine biosynthetic process Source: UniProtKB-HAMAP

Complete GO annotation...

Keywordsⁱ

Molecular function	AminotransferaseUniRule annotationSAAS annotationImported, Transferase
Biological process	Amino-acid biosynthesis, Arginine biosynthesisUniRule annotation
Ligand	Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayⁱ	UPA00068; UER00109.

UniPathwayⁱ

UPA00068; UER00109.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Acetylornithine aminotransferaseUniRule annotation (EC:2.6.1.11UniRule annotation) Short name: ACOATUniRule annotation
Gene namesⁱ	Name:argDUniRule annotation Ordered Locus Names:Deima_1982Imported
Organismⁱ	Deinococcus maricopensis (strain DSM 21211 / LMG 22137 / NRRL B-23946 / LB-34)Imported
Taxonomic identifierⁱ	709986 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus › Deinococcus maricopensis
Proteomesⁱ	UP000008635 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Automatic assertion according to rulesⁱ
- HAMAP-Rule:MF_01107

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

CytoplasmUniRule annotation

PTM / Processingⁱ

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	299	N6-(pyridoxal phosphate)lysineUniRule annotation		1

Interactionⁱ

Subunit structureⁱ

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	709986.Deima_1982.

STRINGⁱ

709986.Deima_1982.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	E8U988.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	133 – 134	Pyridoxal phosphate bindingUniRule annotation		2
Regionⁱ	269 – 272	Pyridoxal phosphate bindingUniRule annotation		4

Sequence similaritiesⁱ

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4108JPW. Bacteria. COG0160. LUCA.
HOGENOMⁱ	HOG000020206.
KEGG Orthology (KO) More...KOⁱ	K00823.
OMAⁱ	GIATCTL.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0APS.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00610. OAT_like. 1 hit.
Gene3Dⁱ	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
HAMAPⁱ	MF_01107. ArgD_aminotrans_3. 1 hit.
InterProⁱ	View protein in InterPro IPR004636. AcOrn/SuccOrn_fam. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_sub2.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00202. Aminotran_3. 1 hit.
PIRSFⁱ	PIRSF000521. Transaminase_4ab_Lys_Orn. 2 hits.
SUPFAMⁱ	SSF53383. SSF53383. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00600. AA_TRANSFER_CLASS_3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

E8U988-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTATTARQPE LKTALPGPNT KAIMERDAKH LSTSYMRPYP FVPDRGEGVW 
        60         70         80         90        100
LTDVDGNTML DFFAGIAVST TGHAHPHVVQ AVQAQIERFA HVCLTDYPQE 
       110        120        130        140        150
ITTSLAERLV RHVERTLPDG RHEKWRVFLG NSGAEAVEAA VKLARNHTGR 
       160        170        180        190        200
SHIISTIGSF HGRTYGAITL TGSKTKYKRG FGPLLPNVSH VPYPNPFRPP 
       210        220        230        240        250
LGSTAETCGQ AVLNYLEDVL FQTVIPADEV AAIIVEPMQG EGGYIVPPAD 
       260        270        280        290        300
FLPGLRALCD RHGIMLIFDE VQAGMGRTGK MFSYQNFDGV QPDIITLAKG 
       310        320        330        340        350
IASGLPISAM MAKESVMTWP VGSHGSTFGG NPVAAAAAHA TLDLLEGAVK 
       360        370        380        390        400
HPGCGDNLMD NARTVGDYIL SELRDMQTEF PFLGDVRGQG LFIGLEFVKP 
       410        420        430        440        450
DGSPDGKLRD AASMAMFERG LLNLDCGESV IRISPPLILT REDAETGLNI 

MRETLRSLQ

Length:459

Mass (Da):49,701

Last modified:April 5, 2011 - v1

Checksum:ⁱ053F3D31E4A07A8C

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP002454 Genomic DNA. Translation: ADV67627.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_013557132.1. NC_014958.1.

Genome annotation databases

EnsemblBacteriaⁱ	ADV67627; ADV67627; Deima_1982.
KEGGⁱ	dmr:Deima_1982.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP002454 Genomic DNA. Translation: ADV67627.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_013557132.1. NC_014958.1.

3D structure databases

ProteinModelPortalⁱ	E8U988.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	709986.Deima_1982.

STRINGⁱ

709986.Deima_1982.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ADV67627; ADV67627; Deima_1982.
KEGGⁱ	dmr:Deima_1982.

Phylogenomic databases

eggNOGⁱ	ENOG4108JPW. Bacteria. COG0160. LUCA.
HOGENOMⁱ	HOG000020206.
KEGG Orthology (KO) More...KOⁱ	K00823.
OMAⁱ	GIATCTL.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0APS.

Enzyme and pathway databases

UniPathwayⁱ	UPA00068; UER00109.

UniPathwayⁱ

UPA00068; UER00109.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00610. OAT_like. 1 hit.
Gene3Dⁱ	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
HAMAPⁱ	MF_01107. ArgD_aminotrans_3. 1 hit.
InterProⁱ	View protein in InterPro IPR004636. AcOrn/SuccOrn_fam. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_sub2.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00202. Aminotran_3. 1 hit.
PIRSFⁱ	PIRSF000521. Transaminase_4ab_Lys_Orn. 2 hits.
SUPFAMⁱ	SSF53383. SSF53383. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00600. AA_TRANSFER_CLASS_3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	E8U988_DEIML
Accessionⁱ	E8U988Primary (citable) accession number: E8U988
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 5, 2011
	Last sequence update:	April 5, 2011
	Last modified:	June 7, 2017
	This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - E8U988 (E8U988_DEIML)

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Acetylornithine aminotransferase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-arginine biosynthesis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

Pathwayⁱ: L-arginine biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ