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E8U988

- E8U988_DEIML

UniProt

E8U988 - E8U988_DEIML

Protein

Acetylornithine/acetyl-lysine aminotransferase

Gene

argD

Organism
Deinococcus maricopensis (strain DSM 21211 / LMG 22137 / NRRL B-23946 / LB-34)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Involved in both the arginine and lysine biosynthetic pathways.UniRule annotation

    Catalytic activityi

    N(2)-acetyl-L-lysine + 2-oxoglutarate = N-acetyl-L-aminoadipate semialdehyde + L-glutamate.UniRule annotation
    N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

    Cofactori

    Binds 1 pyridoxal phosphate per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei160 – 1601Pyridoxal phosphate; via carbonyl oxygenUniRule annotation
    Binding sitei163 – 1631N2-acetyl-L-ornithineUniRule annotation
    Binding sitei326 – 3261N2-acetyl-L-ornithineUniRule annotation
    Binding sitei327 – 3271Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP
    2. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    AminotransferaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesisUniRule annotation, Lysine biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciDMAR709986:GHZG-2028-MONOMER.
    UniPathwayiUPA00033; UER00038.
    UPA00068; UER00109.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetylornithine/acetyl-lysine aminotransferaseUniRule annotation (EC:2.6.1.-UniRule annotation, EC:2.6.1.11UniRule annotation)
    Short name:
    ACOATUniRule annotation
    Gene namesi
    Name:argDUniRule annotation
    Synonyms:lysJUniRule annotation
    Ordered Locus Names:Deima_1982Imported
    OrganismiDeinococcus maricopensis (strain DSM 21211 / LMG 22137 / NRRL B-23946 / LB-34)Imported
    Taxonomic identifieri709986 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000008635: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei299 – 2991N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni269 – 2724Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000020206.
    KOiK00823.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_01107. ArgD_aminotrans_3.
    InterProiIPR004636. AcOrn/SuccOrn_fam.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E8U988-1 [UniParc]FASTAAdd to Basket

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    MTATTARQPE LKTALPGPNT KAIMERDAKH LSTSYMRPYP FVPDRGEGVW    50
    LTDVDGNTML DFFAGIAVST TGHAHPHVVQ AVQAQIERFA HVCLTDYPQE 100
    ITTSLAERLV RHVERTLPDG RHEKWRVFLG NSGAEAVEAA VKLARNHTGR 150
    SHIISTIGSF HGRTYGAITL TGSKTKYKRG FGPLLPNVSH VPYPNPFRPP 200
    LGSTAETCGQ AVLNYLEDVL FQTVIPADEV AAIIVEPMQG EGGYIVPPAD 250
    FLPGLRALCD RHGIMLIFDE VQAGMGRTGK MFSYQNFDGV QPDIITLAKG 300
    IASGLPISAM MAKESVMTWP VGSHGSTFGG NPVAAAAAHA TLDLLEGAVK 350
    HPGCGDNLMD NARTVGDYIL SELRDMQTEF PFLGDVRGQG LFIGLEFVKP 400
    DGSPDGKLRD AASMAMFERG LLNLDCGESV IRISPPLILT REDAETGLNI 450
    MRETLRSLQ 459
    Length:459
    Mass (Da):49,701
    Last modified:April 5, 2011 - v1
    Checksum:i053F3D31E4A07A8C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002454 Genomic DNA. Translation: ADV67627.1.
    RefSeqiYP_004171292.1. NC_014958.1.

    Genome annotation databases

    EnsemblBacteriaiADV67627; ADV67627; Deima_1982.
    GeneIDi10151337.
    KEGGidmr:Deima_1982.
    PATRICi46925045. VBIDeiMar159729_1991.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002454 Genomic DNA. Translation: ADV67627.1 .
    RefSeqi YP_004171292.1. NC_014958.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADV67627 ; ADV67627 ; Deima_1982 .
    GeneIDi 10151337.
    KEGGi dmr:Deima_1982.
    PATRICi 46925045. VBIDeiMar159729_1991.

    Phylogenomic databases

    HOGENOMi HOG000020206.
    KOi K00823.

    Enzyme and pathway databases

    UniPathwayi UPA00033 ; UER00038 .
    UPA00068 ; UER00109 .
    BioCyci DMAR709986:GHZG-2028-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_01107. ArgD_aminotrans_3.
    InterProi IPR004636. AcOrn/SuccOrn_fam.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 21211 / LMG 22137 / NRRL B-23946 / LB-34Imported.

    Entry informationi

    Entry nameiE8U988_DEIML
    AccessioniPrimary (citable) accession number: E8U988
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3