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Protein

Kynureninase

Gene

kynU

Organism
Deinococcus maricopensis (strain DSM 21211 / LMG 22137 / NRRL B-23946 / LB-34)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-kynurenine degradation

This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Kynureninase (kynU)
This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Kynureninase (kynU)
  3. no protein annotated in this organism
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei76Pyridoxal phosphate; via amide nitrogenUniRule annotation1
Binding sitei77Pyridoxal phosphateUniRule annotation1
Binding sitei181Pyridoxal phosphateUniRule annotation1
Binding sitei184Pyridoxal phosphateUniRule annotation1
Binding sitei206Pyridoxal phosphateUniRule annotation1
Binding sitei235Pyridoxal phosphateUniRule annotation1
Binding sitei263Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
Biological processPyridine nucleotide biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynUUniRule annotation
Ordered Locus Names:Deima_1563Imported
OrganismiDeinococcus maricopensis (strain DSM 21211 / LMG 22137 / NRRL B-23946 / LB-34)Imported
Taxonomic identifieri709986 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000008635 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei207N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi709986.Deima_1563.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 333Aminotran_5InterPro annotationAdd BLAST276

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni104 – 107Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKY. Bacteria.
COG3844. LUCA.
HOGENOMiHOG000242438.
KOiK01556.
OMAiVCSLHAS.
OrthoDBiPOG091H0D63.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase. 1 hit.
InterProiView protein in InterPro
IPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiView protein in Pfam
PF00266. Aminotran_5. 1 hit.
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

E8U823-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRDAFPLPP GVYMDGNSLG LMPHAARAAV LRRLDEWATR AVNGWDSWFG
60 70 80 90 100
LAESLAPSVA RLVGAEPHEV AVTGSITSNL HALLATLYRP HGERRHLLAT
110 120 130 140 150
ALDFPSDVYA LQSWAERYGA EVRFVPSRDG HTLDDADIEA SLTYDVAVAL
160 170 180 190 200
LPSVLYRSGQ LLDIPRLTRA AHERGILIGW DAAHSAGSVP HELHAWDADF
210 220 230 240 250
AVWCHYKYVN AGPGAPGGLF LHERHHDLAP GLRGWWGNHK GTQFDMTHTY
260 270 280 290 300
HKAEGAGAYQ QGTPPILALA ALEGALEVFD EVGMPAIRAR SLDLTAHFMR
310 320 330 340 350
AVDAHLPELR VVTPREEARR GGHVALAHPD AHLLSLGLRA RGITPDFRAP
360 370 380 390
DILRLAPVAL YNDERDIDLT VQALRALLDA GHLEQYRAHE QAVR
Length:394
Mass (Da):43,243
Last modified:April 5, 2011 - v1
Checksum:i7A26BB2B818E921D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002454 Genomic DNA. Translation: ADV67212.1.
RefSeqiWP_013556717.1. NC_014958.1.

Genome annotation databases

EnsemblBacteriaiADV67212; ADV67212; Deima_1563.
KEGGidmr:Deima_1563.

Similar proteinsi

Entry informationi

Entry nameiE8U823_DEIML
AccessioniPrimary (citable) accession number: E8U823
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 27, 2017
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported