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E8U823

- E8U823_DEIML

UniProt

E8U823 - E8U823_DEIML

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Protein
Kynureninase
Gene
kynU, Deima_1563
Organism
Deinococcus maricopensis (strain DSM 21211 / LMG 22137 / NRRL B-23946 / LB-34)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei76 – 761Pyridoxal phosphate; via amide nitrogen By similarityUniRule annotation
Binding sitei77 – 771Pyridoxal phosphate By similarityUniRule annotation
Binding sitei181 – 1811Pyridoxal phosphate By similarityUniRule annotation
Binding sitei184 – 1841Pyridoxal phosphate By similarityUniRule annotation
Binding sitei206 – 2061Pyridoxal phosphate By similarityUniRule annotation
Binding sitei235 – 2351Pyridoxal phosphate By similarityUniRule annotation
Binding sitei263 – 2631Pyridoxal phosphate By similarityUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  3. anthranilate metabolic process Source: UniProtKB-HAMAP
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciDMAR709986:GHZG-1607-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolase
Gene namesi
Name:kynUUniRule annotation
Ordered Locus Names:Deima_1563Imported
OrganismiDeinococcus maricopensis (strain DSM 21211 / LMG 22137 / NRRL B-23946 / LB-34)Imported
Taxonomic identifieri709986 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000008635: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei207 – 2071N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni104 – 1074Pyridoxal phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000242438.
KOiK01556.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

E8U823-1 [UniParc]FASTAAdd to Basket

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MKRDAFPLPP GVYMDGNSLG LMPHAARAAV LRRLDEWATR AVNGWDSWFG    50
LAESLAPSVA RLVGAEPHEV AVTGSITSNL HALLATLYRP HGERRHLLAT 100
ALDFPSDVYA LQSWAERYGA EVRFVPSRDG HTLDDADIEA SLTYDVAVAL 150
LPSVLYRSGQ LLDIPRLTRA AHERGILIGW DAAHSAGSVP HELHAWDADF 200
AVWCHYKYVN AGPGAPGGLF LHERHHDLAP GLRGWWGNHK GTQFDMTHTY 250
HKAEGAGAYQ QGTPPILALA ALEGALEVFD EVGMPAIRAR SLDLTAHFMR 300
AVDAHLPELR VVTPREEARR GGHVALAHPD AHLLSLGLRA RGITPDFRAP 350
DILRLAPVAL YNDERDIDLT VQALRALLDA GHLEQYRAHE QAVR 394
Length:394
Mass (Da):43,243
Last modified:April 5, 2011 - v1
Checksum:i7A26BB2B818E921D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002454 Genomic DNA. Translation: ADV67212.1.
RefSeqiYP_004170877.1. NC_014958.1.

Genome annotation databases

EnsemblBacteriaiADV67212; ADV67212; Deima_1563.
GeneIDi10150916.
KEGGidmr:Deima_1563.
PATRICi46924192. VBIDeiMar159729_1571.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002454 Genomic DNA. Translation: ADV67212.1 .
RefSeqi YP_004170877.1. NC_014958.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADV67212 ; ADV67212 ; Deima_1563 .
GeneIDi 10150916.
KEGGi dmr:Deima_1563.
PATRICi 46924192. VBIDeiMar159729_1571.

Phylogenomic databases

HOGENOMi HOG000242438.
KOi K01556.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .
BioCyci DMAR709986:GHZG-1607-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 21211 / LMG 22137 / NRRL B-23946 / LB-34.

Entry informationi

Entry nameiE8U823_DEIML
AccessioniPrimary (citable) accession number: E8U823
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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