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E8U823

- E8U823_DEIML

UniProt

E8U823 - E8U823_DEIML

Protein

Kynureninase

Gene

kynU

Organism
Deinococcus maricopensis (strain DSM 21211 / LMG 22137 / NRRL B-23946 / LB-34)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei76 – 761Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei77 – 771Pyridoxal phosphateUniRule annotation
    Binding sitei181 – 1811Pyridoxal phosphateUniRule annotation
    Binding sitei184 – 1841Pyridoxal phosphateUniRule annotation
    Binding sitei206 – 2061Pyridoxal phosphateUniRule annotation
    Binding sitei235 – 2351Pyridoxal phosphateUniRule annotation
    Binding sitei263 – 2631Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotationImported

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciDMAR709986:GHZG-1607-MONOMER.
    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    Name:kynUUniRule annotation
    Ordered Locus Names:Deima_1563Imported
    OrganismiDeinococcus maricopensis (strain DSM 21211 / LMG 22137 / NRRL B-23946 / LB-34)Imported
    Taxonomic identifieri709986 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000008635: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei207 – 2071N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni104 – 1074Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000242438.
    KOiK01556.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E8U823-1 [UniParc]FASTAAdd to Basket

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    MKRDAFPLPP GVYMDGNSLG LMPHAARAAV LRRLDEWATR AVNGWDSWFG    50
    LAESLAPSVA RLVGAEPHEV AVTGSITSNL HALLATLYRP HGERRHLLAT 100
    ALDFPSDVYA LQSWAERYGA EVRFVPSRDG HTLDDADIEA SLTYDVAVAL 150
    LPSVLYRSGQ LLDIPRLTRA AHERGILIGW DAAHSAGSVP HELHAWDADF 200
    AVWCHYKYVN AGPGAPGGLF LHERHHDLAP GLRGWWGNHK GTQFDMTHTY 250
    HKAEGAGAYQ QGTPPILALA ALEGALEVFD EVGMPAIRAR SLDLTAHFMR 300
    AVDAHLPELR VVTPREEARR GGHVALAHPD AHLLSLGLRA RGITPDFRAP 350
    DILRLAPVAL YNDERDIDLT VQALRALLDA GHLEQYRAHE QAVR 394
    Length:394
    Mass (Da):43,243
    Last modified:April 5, 2011 - v1
    Checksum:i7A26BB2B818E921D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002454 Genomic DNA. Translation: ADV67212.1.
    RefSeqiYP_004170877.1. NC_014958.1.

    Genome annotation databases

    EnsemblBacteriaiADV67212; ADV67212; Deima_1563.
    GeneIDi10150916.
    KEGGidmr:Deima_1563.
    PATRICi46924192. VBIDeiMar159729_1571.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002454 Genomic DNA. Translation: ADV67212.1 .
    RefSeqi YP_004170877.1. NC_014958.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADV67212 ; ADV67212 ; Deima_1563 .
    GeneIDi 10150916.
    KEGGi dmr:Deima_1563.
    PATRICi 46924192. VBIDeiMar159729_1571.

    Phylogenomic databases

    HOGENOMi HOG000242438.
    KOi K01556.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .
    BioCyci DMAR709986:GHZG-1607-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 21211 / LMG 22137 / NRRL B-23946 / LB-34Imported.

    Entry informationi

    Entry nameiE8U823_DEIML
    AccessioniPrimary (citable) accession number: E8U823
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3