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E8TYH2 (E8TYH2_ALIDB) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate By similarity. HAMAP-Rule MF_00131 RuleBase RU000601 SAAS SAAS018204

Catalytic activity

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. HAMAP-Rule MF_00131 RuleBase RU000601 SAAS SAAS018204

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5. HAMAP-Rule MF_00131 RuleBase RU000601 SAAS SAAS018204

Subunit structure

Tetramer of two alpha and two beta chains By similarity. HAMAP-Rule MF_00131 RuleBase RU000601 SAAS SAAS018204

Sequence similarities

Belongs to the TrpA family. HAMAP-Rule MF_00131 RuleBase RU003662

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site491Proton acceptor By similarity HAMAP-Rule MF_00131
Active site601Proton acceptor By similarity HAMAP-Rule MF_00131

Sequences

Sequence LengthMass (Da)Tools
E8TYH2 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: 43AB4688E81A98F6

FASTA26928,723
        10         20         30         40         50         60 
MSRIADTFAA LQEKGRKALI PYVTAGFPFA DITPALMHGM VEAGADVIEL GVPFSDPMAD 

        70         80         90        100        110        120 
GPVIQKAGEK ALSLGIGMPQ VLEMVRSFRQ RNQTTPVVLM GYANPVERYD QRHGKGAFAR 

       130        140        150        160        170        180 
DAGAAGVDGV LVVDYPPEEC EQFAADLRAH GIDLIFLLAP TSTPERMQQV ARVASGYVYY 

       190        200        210        220        230        240 
VSLKGVTGSG ALDTAAVESM LPRIREHVKI PVGVGFGIRD AATAQAIGRV ADAVVIGSRI 

       250        260 
IQLIEDQPHE KVVGITVDFL RGIRKALDA

« Hide

References

[1]"Complete sequence of chromosome of Alicycliphilus denitrificans BC."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Daligault H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mikhailova N., Oosterkamp M.J., Veuskens T., Weelink S.A. expand/collapse author list , Plugge C.M., Stams A.J.M., Woyke T.
Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCM 14587 / BC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002449 Genomic DNA. Translation: ADV00870.1.
RefSeqYP_004127757.1. NC_014910.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADV00870; ADV00870; Alide_3148.
GeneID10105219.
KEGGadn:Alide_3148.
PATRIC45145194. VBIAliDen149934_3264.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000223815.
KOK01695.

Enzyme and pathway databases

BioCycADEN596153:GHGY-3288-MONOMER.
UniPathwayUPA00035; UER00044.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00131. Trp_synth_alpha.
InterProIPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR018204. Trp_synthase_alpha_AS.
IPR002028. Trp_synthase_suA.
[Graphical view]
PfamPF00290. Trp_syntA. 1 hit.
[Graphical view]
SUPFAMSSF51366. RibP_bind_barrel. 1 hit.
TIGRFAMsTIGR00262. trpA. 1 hit.
PROSITEPS00167. TRP_SYNTHASE_ALPHA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE8TYH2_ALIDB
AccessionPrimary (citable) accession number: E8TYH2
Entry history
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: May 1, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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