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E8TSL6 (E8TSL6_ALIDB) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] RuleBase RU004446
EC=1.1.1.42 RuleBase RU004446
Gene names
Ordered Locus Names:Alide_2620 EMBL ADV00352.1
OrganismAlicycliphilus denitrificans (strain JCM 14587 / BC) [Complete proteome] [HAMAP] EMBL ADV00352.1
Taxonomic identifier596153 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Alicycliphilus ›

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. RuleBase RU004446

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. RuleBase RU004446

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443

Sequences

Sequence LengthMass (Da)Tools
E8TSL6 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: 7AAC4F2A3FB9A61F

FASTA41946,076
        10         20         30         40         50         60 
MTSYQHIKVP AEGQKITVQA DMSLNVPDQP IIPYIEGDGT GVDITPVMLK VVDAAVAKAY 

        70         80         90        100        110        120 
GGRRKIHWME VYAGEKSTRV YGPDVWLPEE TLHAVRDYVV SIKGPLTTPV GGGIRSLNVA 

       130        140        150        160        170        180 
LRQELDLYVC LRPVQYFKGV PSPVKEPHKT NMVIFRENSE DIYAGVEFEA QSDKAKKLIK 

       190        200        210        220        230        240 
ILQDEFGVKK IRFPETSGIG IKPVSREGTQ RLVRKAIQYA IDNDKPSVTL VHKGNIMKFT 

       250        260        270        280        290        300 
EGAFRDWGYE LAAKEFGATP IDGGPWMRLK NPRTGKEITI KDSIADAFLQ QILLRPAEYS 

       310        320        330        340        350        360 
VIATLNLNGD YISDALAAQV GGIGIAPGAN MSDSVAMFEA THGTAPKYAG KDYVNPGSEI 

       370        380        390        400        410 
LSAEMMLRHM GWTEAADLII QSMEKAIQSK KVTYDFARLM EGATQVSCSG FGQVMIDNM

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References

[1]"Complete sequence of chromosome of Alicycliphilus denitrificans BC."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Daligault H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mikhailova N., Oosterkamp M.J., Veuskens T., Weelink S.A. expand/collapse author list , Plugge C.M., Stams A.J.M., Woyke T.
Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCM 14587 / BC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002449 Genomic DNA. Translation: ADV00352.1.
RefSeqYP_004127239.1. NC_014910.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADV00352; ADV00352; Alide_2620.
GeneID10104680.
KEGGadn:Alide_2620.
PATRIC45144075. VBIAliDen149934_2721.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000021113.
KOK00031.

Enzyme and pathway databases

BioCycADEN596153:GHGY-2658-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11835. PTHR11835. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR00183. prok_nadp_idh. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE8TSL6_ALIDB
AccessionPrimary (citable) accession number: E8TSL6
Entry history
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: May 29, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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