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Protein

Isocitrate dehydrogenase [NADP]

Gene

Alide_2620

Organism
Alicycliphilus denitrificans (strain DSM 18852 / JCM 14587 / BC)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciADEN596153:GHGY-2658-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Alide_2620Imported
OrganismiAlicycliphilus denitrificans (strain DSM 18852 / JCM 14587 / BC)Imported
Taxonomic identifieri596153 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAlicycliphilus
ProteomesiUP000006626: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8TSL6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSYQHIKVP AEGQKITVQA DMSLNVPDQP IIPYIEGDGT GVDITPVMLK
60 70 80 90 100
VVDAAVAKAY GGRRKIHWME VYAGEKSTRV YGPDVWLPEE TLHAVRDYVV
110 120 130 140 150
SIKGPLTTPV GGGIRSLNVA LRQELDLYVC LRPVQYFKGV PSPVKEPHKT
160 170 180 190 200
NMVIFRENSE DIYAGVEFEA QSDKAKKLIK ILQDEFGVKK IRFPETSGIG
210 220 230 240 250
IKPVSREGTQ RLVRKAIQYA IDNDKPSVTL VHKGNIMKFT EGAFRDWGYE
260 270 280 290 300
LAAKEFGATP IDGGPWMRLK NPRTGKEITI KDSIADAFLQ QILLRPAEYS
310 320 330 340 350
VIATLNLNGD YISDALAAQV GGIGIAPGAN MSDSVAMFEA THGTAPKYAG
360 370 380 390 400
KDYVNPGSEI LSAEMMLRHM GWTEAADLII QSMEKAIQSK KVTYDFARLM
410
EGATQVSCSG FGQVMIDNM
Length:419
Mass (Da):46,076
Last modified:April 5, 2011 - v1
Checksum:i7AAC4F2A3FB9A61F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002449 Genomic DNA. Translation: ADV00352.1.
RefSeqiWP_013519441.1. NC_014910.1.
YP_004127239.1. NC_014910.1.

Genome annotation databases

EnsemblBacteriaiADV00352; ADV00352; Alide_2620.
GeneIDi10104680.
KEGGiadn:Alide_2620.
PATRICi45144075. VBIAliDen149934_2721.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002449 Genomic DNA. Translation: ADV00352.1.
RefSeqiWP_013519441.1. NC_014910.1.
YP_004127239.1. NC_014910.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADV00352; ADV00352; Alide_2620.
GeneIDi10104680.
KEGGiadn:Alide_2620.
PATRICi45144075. VBIAliDen149934_2721.

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.

Enzyme and pathway databases

BioCyciADEN596153:GHGY-2658-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Alicycliphilus denitrificans BC."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Daligault H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mikhailova N., Oosterkamp M.J., Veuskens T., Weelink S.A.
    , Plugge C.M., Stams A.J.M., Woyke T.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 14587 / BCImported.

Entry informationi

Entry nameiE8TSL6_ALIDB
AccessioniPrimary (citable) accession number: E8TSL6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: February 4, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.