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E8TSL6

- E8TSL6_ALIDB

UniProt

E8TSL6 - E8TSL6_ALIDB

Protein

Isocitrate dehydrogenase [NADP]

Gene

Alide_2620

Organism
Alicycliphilus denitrificans (strain DSM 18852 / JCM 14587 / BC)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciADEN596153:GHGY-2658-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:Alide_2620Imported
    OrganismiAlicycliphilus denitrificans (strain DSM 18852 / JCM 14587 / BC)Imported
    Taxonomic identifieri596153 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAlicycliphilus
    ProteomesiUP000006626: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000021113.
    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E8TSL6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSYQHIKVP AEGQKITVQA DMSLNVPDQP IIPYIEGDGT GVDITPVMLK    50
    VVDAAVAKAY GGRRKIHWME VYAGEKSTRV YGPDVWLPEE TLHAVRDYVV 100
    SIKGPLTTPV GGGIRSLNVA LRQELDLYVC LRPVQYFKGV PSPVKEPHKT 150
    NMVIFRENSE DIYAGVEFEA QSDKAKKLIK ILQDEFGVKK IRFPETSGIG 200
    IKPVSREGTQ RLVRKAIQYA IDNDKPSVTL VHKGNIMKFT EGAFRDWGYE 250
    LAAKEFGATP IDGGPWMRLK NPRTGKEITI KDSIADAFLQ QILLRPAEYS 300
    VIATLNLNGD YISDALAAQV GGIGIAPGAN MSDSVAMFEA THGTAPKYAG 350
    KDYVNPGSEI LSAEMMLRHM GWTEAADLII QSMEKAIQSK KVTYDFARLM 400
    EGATQVSCSG FGQVMIDNM 419
    Length:419
    Mass (Da):46,076
    Last modified:April 5, 2011 - v1
    Checksum:i7AAC4F2A3FB9A61F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002449 Genomic DNA. Translation: ADV00352.1.
    RefSeqiWP_013519441.1. NC_014910.1.
    YP_004127239.1. NC_014910.1.

    Genome annotation databases

    EnsemblBacteriaiADV00352; ADV00352; Alide_2620.
    GeneIDi10104680.
    KEGGiadn:Alide_2620.
    PATRICi45144075. VBIAliDen149934_2721.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002449 Genomic DNA. Translation: ADV00352.1 .
    RefSeqi WP_013519441.1. NC_014910.1.
    YP_004127239.1. NC_014910.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADV00352 ; ADV00352 ; Alide_2620 .
    GeneIDi 10104680.
    KEGGi adn:Alide_2620.
    PATRICi 45144075. VBIAliDen149934_2721.

    Phylogenomic databases

    HOGENOMi HOG000021113.
    KOi K00031.

    Enzyme and pathway databases

    BioCyci ADEN596153:GHGY-2658-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Alicycliphilus denitrificans BC."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Daligault H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mikhailova N., Oosterkamp M.J., Veuskens T., Weelink S.A.
      , Plugge C.M., Stams A.J.M., Woyke T.
      Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 14587 / BCImported.

    Entry informationi

    Entry nameiE8TSL6_ALIDB
    AccessioniPrimary (citable) accession number: E8TSL6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3