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E8TSL6

- E8TSL6_ALIDB

UniProt

E8TSL6 - E8TSL6_ALIDB

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Protein

Isocitrate dehydrogenase [NADP]

Gene

Alide_2620

Organism
Alicycliphilus denitrificans (strain DSM 18852 / JCM 14587 / BC)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciADEN596153:GHGY-2658-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Alide_2620Imported
OrganismiAlicycliphilus denitrificans (strain DSM 18852 / JCM 14587 / BC)Imported
Taxonomic identifieri596153 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAlicycliphilus
ProteomesiUP000006626: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8TSL6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSYQHIKVP AEGQKITVQA DMSLNVPDQP IIPYIEGDGT GVDITPVMLK
60 70 80 90 100
VVDAAVAKAY GGRRKIHWME VYAGEKSTRV YGPDVWLPEE TLHAVRDYVV
110 120 130 140 150
SIKGPLTTPV GGGIRSLNVA LRQELDLYVC LRPVQYFKGV PSPVKEPHKT
160 170 180 190 200
NMVIFRENSE DIYAGVEFEA QSDKAKKLIK ILQDEFGVKK IRFPETSGIG
210 220 230 240 250
IKPVSREGTQ RLVRKAIQYA IDNDKPSVTL VHKGNIMKFT EGAFRDWGYE
260 270 280 290 300
LAAKEFGATP IDGGPWMRLK NPRTGKEITI KDSIADAFLQ QILLRPAEYS
310 320 330 340 350
VIATLNLNGD YISDALAAQV GGIGIAPGAN MSDSVAMFEA THGTAPKYAG
360 370 380 390 400
KDYVNPGSEI LSAEMMLRHM GWTEAADLII QSMEKAIQSK KVTYDFARLM
410
EGATQVSCSG FGQVMIDNM
Length:419
Mass (Da):46,076
Last modified:April 5, 2011 - v1
Checksum:i7AAC4F2A3FB9A61F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002449 Genomic DNA. Translation: ADV00352.1.
RefSeqiYP_004127239.1. NC_014910.1.

Genome annotation databases

EnsemblBacteriaiADV00352; ADV00352; Alide_2620.
GeneIDi10104680.
KEGGiadn:Alide_2620.
PATRICi45144075. VBIAliDen149934_2721.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002449 Genomic DNA. Translation: ADV00352.1 .
RefSeqi YP_004127239.1. NC_014910.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADV00352 ; ADV00352 ; Alide_2620 .
GeneIDi 10104680.
KEGGi adn:Alide_2620.
PATRICi 45144075. VBIAliDen149934_2721.

Phylogenomic databases

HOGENOMi HOG000021113.
KOi K00031.

Enzyme and pathway databases

BioCyci ADEN596153:GHGY-2658-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Alicycliphilus denitrificans BC."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Daligault H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mikhailova N., Oosterkamp M.J., Veuskens T., Weelink S.A.
    , Plugge C.M., Stams A.J.M., Woyke T.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 14587 / BCImported.

Entry informationi

Entry nameiE8TSL6_ALIDB
AccessioniPrimary (citable) accession number: E8TSL6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 29, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3