ID E8TLH3_MESCW Unreviewed; 391 AA. AC E8TLH3; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 27-MAR-2024, entry version 75. DE RecName: Full=Elongation factor Tu {ECO:0000256|ARBA:ARBA00029554, ECO:0000256|HAMAP-Rule:MF_00118}; DE Short=EF-Tu {ECO:0000256|HAMAP-Rule:MF_00118}; GN Name=tuf {ECO:0000256|HAMAP-Rule:MF_00118}; GN OrderedLocusNames=Mesci_3604 {ECO:0000313|EMBL:ADV12724.1}, Mesci_3624 GN {ECO:0000313|EMBL:ADV12744.1}; OS Mesorhizobium ciceri biovar biserrulae (strain HAMBI 2942 / LMG 23838 / OS WSM1271). OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales; OC Phyllobacteriaceae; Mesorhizobium. OX NCBI_TaxID=765698 {ECO:0000313|EMBL:ADV12724.1, ECO:0000313|Proteomes:UP000007471}; RN [1] {ECO:0000313|EMBL:ADV12724.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=WSM1271 {ECO:0000313|EMBL:ADV12724.1}; RG US DOE Joint Genome Institute; RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., RA Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., RA Ivanova N., Nandasena K., Reeve W.G., Howieson J.G., O'Hara G., RA Tiwari R.P., Woyke T.; RT "Complete sequence of chromosome of Mesorhizobium ciceri bv. biserrulae RT WSM1271."; RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000007471} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=HAMBI 2942 / LMG 23838 / WSM1271 RC {ECO:0000313|Proteomes:UP000007471}; RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., RA Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., RA Ivanova N., Nandasena K., Reeve W.G., Howieson J.G., O'Hara G., RA Tiwari R.P., Woyke T.; RT "Complete sequence of chromosome of Mesorhizobium ciceri bv. biserrulae RT WSM1271."; RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl- CC tRNA to the A-site of ribosomes during protein biosynthesis. CC {ECO:0000256|HAMAP-Rule:MF_00118}. CC -!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_00118}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00118}. CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase CC superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A CC subfamily. {ECO:0000256|ARBA:ARBA00007249, ECO:0000256|HAMAP- CC Rule:MF_00118}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP002447; ADV12724.1; -; Genomic_DNA. DR EMBL; CP002447; ADV12744.1; -; Genomic_DNA. DR RefSeq; WP_013531404.1; NC_014923.1. DR RefSeq; YP_004142774.1; NC_014923.1. DR RefSeq; YP_004142794.1; NC_014923.1. DR AlphaFoldDB; E8TLH3; -. DR STRING; 765698.Mesci_3604; -. DR KEGG; mci:Mesci_3604; -. DR KEGG; mci:Mesci_3624; -. DR PATRIC; fig|765698.3.peg.4109; -. DR eggNOG; COG0050; Bacteria. DR HOGENOM; CLU_007265_0_1_5; -. DR OrthoDB; 9803139at2; -. DR Proteomes; UP000007471; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule. DR GO; GO:0003924; F:GTPase activity; IEA:InterPro. DR GO; GO:0097216; F:guanosine tetraphosphate binding; IEA:UniProt. DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-UniRule. DR CDD; cd01884; EF_Tu; 1. DR CDD; cd03697; EFTU_II; 1. DR CDD; cd03707; EFTU_III; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1. DR Gene3D; 2.40.30.10; Translation factors; 2. DR HAMAP; MF_00118_B; EF_Tu_B; 1. DR InterPro; IPR041709; EF-Tu_GTP-bd. DR InterPro; IPR004161; EFTu-like_2. DR InterPro; IPR033720; EFTU_2. DR InterPro; IPR031157; G_TR_CS. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR005225; Small_GTP-bd_dom. DR InterPro; IPR000795; T_Tr_GTP-bd_dom. DR InterPro; IPR009000; Transl_B-barrel_sf. DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C. DR InterPro; IPR004541; Transl_elong_EFTu/EF1A_bac/org. DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C. DR NCBIfam; TIGR00485; EF-Tu; 1. DR NCBIfam; TIGR00231; small_GTP; 1. DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1. DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1. DR Pfam; PF00009; GTP_EFTU; 1. DR Pfam; PF03144; GTP_EFTU_D2; 1. DR Pfam; PF03143; GTP_EFTU_D3; 1. DR PRINTS; PR00315; ELONGATNFCT. DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR SUPFAM; SSF50447; Translation proteins; 1. DR PROSITE; PS00301; G_TR_1; 1. DR PROSITE; PS51722; G_TR_2; 1. PE 3: Inferred from homology; KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00118}; KW Elongation factor {ECO:0000256|ARBA:ARBA00022768, ECO:0000256|HAMAP- KW Rule:MF_00118}; KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|HAMAP- KW Rule:MF_00118}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP- KW Rule:MF_00118}; KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP- KW Rule:MF_00118}. FT DOMAIN 10..201 FT /note="Tr-type G" FT /evidence="ECO:0000259|PROSITE:PS51722" FT BINDING 19..26 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00118" FT BINDING 76..80 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00118" FT BINDING 131..134 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00118" SQ SEQUENCE 391 AA; 42769 MW; 87954F20DF0EB633 CRC64; MAKGKFERNK PHVNIGTIGH VDHGKTSLTA AITKYFGEYK RYDQIDAAPE EKARGITIST AHVEYETANR HYAHVDCPGH ADYVKNMITG AAQMDGAILV VSAADGPMPQ TREHILLARQ VGVPSIVVFL NKVDQVDDAE LLELVELEVR ELLTKNEFPG DDIPIVKGSA LAALEDSDKK IGEDAIRELM AAVDAYIPTP VRPLDKPFLM PIEDVFSISG RGTVVTGRVE RGVVKVGEEL EIIGIRPTTK TTCTGVEMFR KLLDQGQAGD NIGALLRGVD REGVERGQVL AKPGTVKPHK KFVAEAYILT KDEGGRHTPF FTNYRPQFYF RTTDVTGIVS LPEGTEMVMP GDNITVDVEL IVPIAMEEKL RFAIREGGRT VGAGIVVTIK E //