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Protein

Alanine racemase

Gene

Mesci_5615

Organism
Mesorhizobium ciceri bv. biserrulae (strain HAMBI 2942 / LMG 23838 / WSM1271)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathway: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Mesci_1221), Alanine racemase (Mesci_5615)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei51 – 511Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei145 – 1451SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMCIC765698:GHQ5-5677-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Mesci_5615Imported
OrganismiMesorhizobium ciceri bv. biserrulae (strain HAMBI 2942 / LMG 23838 / WSM1271)Imported
Taxonomic identifieri765698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
ProteomesiUP000007471 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 511N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi765698.Mesci_5615.

Structurei

3D structure databases

ProteinModelPortaliE8TGJ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000118797.
KOiK01775.
OMAiKIYFVCK.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

E8TGJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCALTSIAPV QSKKAASREA WYEIDLGAIR HNYRQLRRHL PRTVKIFACL
60 70 80 90 100
KRNAYGCGAG PVARTLATEG ADGFAVATLP DAMAIREMGI DLPVLLYPGP
110 120 130 140 150
LPTSAKTIEA LGLTVTVSSL DELESWRAAM SVTRIFVKAD LGFFRAGATP
160 170 180 190 200
QEIGRLLAAA HVCSDVEVQG LYAHLSELPT SVTSDASEQF SRLQRILQDA
210 220 230 240 250
EASGTRPPII MMSSTAGVLR HPAMDLDAVD PGALFIGLPE TDRPMRAVTL
260 270 280 290 300
RPALKAISTC LVSVKRIDAS LGPIPDIPGF RSGMTIGVLG MGWGDGLPRH
310 320 330 340 350
VPAQAEALVR GQRARLLPPA HLEHLRIDLT DVPDARFGDQ VLLLGQQAHQ
360 370 380
TISHEEVAAQ WGTDLIGLYA QLRDHIPRVY V
Length:381
Mass (Da):41,101
Last modified:April 5, 2011 - v1
Checksum:i4D8E7F932A0A0415
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002447 Genomic DNA. Translation: ADV14707.1.
RefSeqiWP_013533357.1. NC_014923.1.
YP_004144757.1. NC_014923.1.

Genome annotation databases

EnsemblBacteriaiADV14707; ADV14707; Mesci_5615.
GeneIDi10121115.
KEGGimci:Mesci_5615.
PATRICi45261463. VBIMesCic160642_6138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002447 Genomic DNA. Translation: ADV14707.1.
RefSeqiWP_013533357.1. NC_014923.1.
YP_004144757.1. NC_014923.1.

3D structure databases

ProteinModelPortaliE8TGJ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi765698.Mesci_5615.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADV14707; ADV14707; Mesci_5615.
GeneIDi10121115.
KEGGimci:Mesci_5615.
PATRICi45261463. VBIMesCic160642_6138.

Phylogenomic databases

HOGENOMiHOG000118797.
KOiK01775.
OMAiKIYFVCK.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciMCIC765698:GHQ5-5677-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Mesorhizobium ciceri bv. biserrulae WSM1271."
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Nandasena K., Reeve W.G., Howieson J.G., O'Hara G., Tiwari R.P., Woyke T.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAMBI 2942 / LMG 23838 / WSM1271Imported.

Entry informationi

Entry nameiE8TGJ4_MESCW
AccessioniPrimary (citable) accession number: E8TGJ4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 24, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.