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Protein

Alanine racemase

Gene

Mesci_5615

Organism
Mesorhizobium ciceri biovar biserrulae (strain HAMBI 2942 / LMG 23838 / WSM1271)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Mesci_1221), Alanine racemase (Mesci_5615)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei51Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei145SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMCIC765698:GHQ5-5593-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Mesci_5615Imported
OrganismiMesorhizobium ciceri biovar biserrulae (strain HAMBI 2942 / LMG 23838 / WSM1271)Imported
Taxonomic identifieri765698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000007471 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi765698.Mesci_5615

Structurei

3D structure databases

ProteinModelPortaliE8TGJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini253 – 381Ala_racemase_CInterPro annotationAdd BLAST129

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787 LUCA
HOGENOMiHOG000118797
KOiK01775
OMAiISHFACA
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit

Sequencei

Sequence statusi: Complete.

E8TGJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCALTSIAPV QSKKAASREA WYEIDLGAIR HNYRQLRRHL PRTVKIFACL
60 70 80 90 100
KRNAYGCGAG PVARTLATEG ADGFAVATLP DAMAIREMGI DLPVLLYPGP
110 120 130 140 150
LPTSAKTIEA LGLTVTVSSL DELESWRAAM SVTRIFVKAD LGFFRAGATP
160 170 180 190 200
QEIGRLLAAA HVCSDVEVQG LYAHLSELPT SVTSDASEQF SRLQRILQDA
210 220 230 240 250
EASGTRPPII MMSSTAGVLR HPAMDLDAVD PGALFIGLPE TDRPMRAVTL
260 270 280 290 300
RPALKAISTC LVSVKRIDAS LGPIPDIPGF RSGMTIGVLG MGWGDGLPRH
310 320 330 340 350
VPAQAEALVR GQRARLLPPA HLEHLRIDLT DVPDARFGDQ VLLLGQQAHQ
360 370 380
TISHEEVAAQ WGTDLIGLYA QLRDHIPRVY V
Length:381
Mass (Da):41,101
Last modified:April 5, 2011 - v1
Checksum:i4D8E7F932A0A0415
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002447 Genomic DNA Translation: ADV14707.1
RefSeqiWP_013533357.1, NC_014923.1
YP_004144757.1, NC_014923.1

Genome annotation databases

EnsemblBacteriaiADV14707; ADV14707; Mesci_5615
GeneIDi10121115
KEGGimci:Mesci_5615
PATRICifig|765698.3.peg.6138

Similar proteinsi

Entry informationi

Entry nameiE8TGJ4_MESCW
AccessioniPrimary (citable) accession number: E8TGJ4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: February 28, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health