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E8TEA0

- E8TEA0_MESCW

UniProt

E8TEA0 - E8TEA0_MESCW

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Protein

Ribulose bisphosphate carboxylase large chain

Gene
cbbL, Mesci_4283
Organism
Mesorhizobium ciceri bv. biserrulae (strain HAMBI 2942 / LMG 23838 / WSM1271)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site By similarity.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei136 – 1361Substrate; in homodimeric partner By similarityUniRule annotation
Binding sitei186 – 1861Substrate By similarityUniRule annotation
Active sitei188 – 1881Proton acceptor By similarityUniRule annotation
Binding sitei190 – 1901Substrate By similarityUniRule annotation
Metal bindingi214 – 2141Magnesium; via carbamate group By similarityUniRule annotation
Metal bindingi216 – 2161Magnesium By similarityUniRule annotation
Metal bindingi217 – 2171Magnesium By similarityUniRule annotation
Active sitei306 – 3061Proton acceptor By similarityUniRule annotation
Binding sitei307 – 3071Substrate By similarityUniRule annotation
Binding sitei339 – 3391Substrate By similarityUniRule annotation
Sitei346 – 3461Transition state stabilizer By similarityUniRule annotation
Binding sitei391 – 3911Substrate By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. monooxygenase activity Source: UniProtKB-KW
  3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. reductive pentose-phosphate cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported, MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Biological processi

Calvin cycleUniRule annotation, Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciMCIC765698:GHQ5-4336-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylase large chainUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCO large subunitUniRule annotation
Gene namesi
Name:cbbLUniRule annotation
Ordered Locus Names:Mesci_4283Imported
OrganismiMesorhizobium ciceri bv. biserrulae (strain HAMBI 2942 / LMG 23838 / WSM1271)Imported
Taxonomic identifieri765698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
ProteomesiUP000007471: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei214 – 2141N6-carboxylysine By similarityUniRule annotation

Interactioni

Subunit structurei

Heterohexadecamer of 8 large chains and 8 small chains By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE8TEA0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000230831.
KOiK01601.
OMAiCTPLKQA.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01338. RuBisCO_L_type1.
InterProiIPR020878. RuBisCo_large_chain_AS.
IPR020888. RuBisCO_lsu.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8TEA0-1 [UniParc]FASTAAdd to Basket

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MNKIDILPAG TLKEGKERYK SGVIPYKKMG YWEPDYRPKE TDLIAMFRIT    50
PQPGVDHEEA AAAIAGESST ATWTVVWTDR LTACELYRAK AFRSEPVPNT 100
GPGTKTEQQY FAYIAYDLDL FEPGSIANLT ASIIGNVFGF KAVKALRLED 150
MRIPVAYLKT FQGPATGIVV ERERLDKFGR PLLGATTKPK LGLSGRNYGR 200
VVYEALKGGL DFVKDDENIN SQPFMHWRDR FLYCMEAVNK ASAATGEVKG 250
HYLNVTAGTM EEMYERAEFA KQLGSCIVMI DLVIGYTAIQ SMAKWARRND 300
MILHLHRAGN STYSRQKNHG MNFRVICKWM RMAGVDHIHA GTVVGKLEGD 350
PLMIKGFYDT LREERTPQNL ETGLFFDQEW ASLNKVMPVA SGGIHAGQMH 400
QLIHYLGEDV ILQFGGGTIG HPDGIQAGAT ANRVALEAMI LARNEGRDYL 450
REGTKILEQA ARWCTPLKAA LETWKDVTFN YESTDTADFV PTATPSF 497
Length:497
Mass (Da):55,476
Last modified:April 5, 2011 - v1
Checksum:i95D543D064004907
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002447 Genomic DNA. Translation: ADV13393.1.
RefSeqiWP_013532056.1. NC_014923.1.
YP_004143443.1. NC_014923.1.

Genome annotation databases

EnsemblBacteriaiADV13393; ADV13393; Mesci_4283.
GeneIDi10119774.
KEGGimci:Mesci_4283.
PATRICi45258702. VBIMesCic160642_4780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002447 Genomic DNA. Translation: ADV13393.1 .
RefSeqi WP_013532056.1. NC_014923.1.
YP_004143443.1. NC_014923.1.

3D structure databases

ProteinModelPortali E8TEA0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADV13393 ; ADV13393 ; Mesci_4283 .
GeneIDi 10119774.
KEGGi mci:Mesci_4283.
PATRICi 45258702. VBIMesCic160642_4780.

Phylogenomic databases

HOGENOMi HOG000230831.
KOi K01601.
OMAi CTPLKQA.

Enzyme and pathway databases

BioCyci MCIC765698:GHQ5-4336-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPi MF_01338. RuBisCO_L_type1.
InterProi IPR020878. RuBisCo_large_chain_AS.
IPR020888. RuBisCO_lsu.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
PROSITEi PS00157. RUBISCO_LARGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Mesorhizobium ciceri bv. biserrulae WSM1271."
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Nandasena K., Reeve W.G., Howieson J.G., O'Hara G., Tiwari R.P., Woyke T.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAMBI 2942 / LMG 23838 / WSM1271.

Entry informationi

Entry nameiE8TEA0_MESCW
AccessioniPrimary (citable) accession number: E8TEA0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 3, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric "cap" on each end of the "barrel" By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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