ID   E8T7B6_MESCW            Unreviewed;       329 AA.
AC   E8T7B6;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   RecName: Full=Xylose isomerase {ECO:0000256|RuleBase:RU000609};
DE            EC=5.3.1.5 {ECO:0000256|RuleBase:RU000609};
GN   OrderedLocusNames=Mesci_1361 {ECO:0000313|EMBL:ADV10521.1};
OS   Mesorhizobium ciceri biovar biserrulae (strain HAMBI 2942 / LMG 23838 /
OS   WSM1271).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Phyllobacteriaceae; Mesorhizobium.
OX   NCBI_TaxID=765698 {ECO:0000313|EMBL:ADV10521.1, ECO:0000313|Proteomes:UP000007471};
RN   [1] {ECO:0000313|Proteomes:UP000007471}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HAMBI 2942 / LMG 23838 / WSM1271
RC   {ECO:0000313|Proteomes:UP000007471};
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N.,
RA   Ivanova N., Nandasena K., Reeve W.G., Howieson J.G., O'Hara G.,
RA   Tiwari R.P., Woyke T.;
RT   "Complete sequence of chromosome of Mesorhizobium ciceri bv. biserrulae
RT   WSM1271.";
RL   Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-xylose = alpha-D-xylulofuranose; Xref=Rhea:RHEA:22816,
CC         ChEBI:CHEBI:28518, ChEBI:CHEBI:188998; EC=5.3.1.5;
CC         Evidence={ECO:0000256|RuleBase:RU000609};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|RuleBase:RU000610}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|RuleBase:RU000610}.
CC   -!- SIMILARITY: Belongs to the xylose isomerase family.
CC       {ECO:0000256|ARBA:ARBA00005765, ECO:0000256|RuleBase:RU000609}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP002447; ADV10521.1; -; Genomic_DNA.
DR   RefSeq; WP_013529215.1; NC_014923.1.
DR   RefSeq; YP_004140571.1; NC_014923.1.
DR   AlphaFoldDB; E8T7B6; -.
DR   STRING; 765698.Mesci_1361; -.
DR   KEGG; mci:Mesci_1361; -.
DR   PATRIC; fig|765698.3.peg.1801; -.
DR   eggNOG; COG4952; Bacteria.
DR   HOGENOM; CLU_072264_0_0_5; -.
DR   OrthoDB; 9801426at2; -.
DR   Proteomes; UP000007471; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009045; F:xylose isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.150; Divalent-metal-dependent TIM barrel enzymes; 1.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR   InterPro; IPR001998; Xylose_isomerase.
DR   PANTHER; PTHR30268; L-RHAMNOSE ISOMERASE; 1.
DR   PANTHER; PTHR30268:SF0; L-RHAMNOSE ISOMERASE; 1.
DR   Pfam; PF01261; AP_endonuc_2; 1.
DR   PRINTS; PR00688; XYLOSISMRASE.
DR   SUPFAM; SSF51658; Xylose isomerase-like; 1.
DR   PROSITE; PS51415; XYLOSE_ISOMERASE; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277,
KW   ECO:0000256|RuleBase:RU000609}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU000609};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU000609};
KW   Xylose metabolism {ECO:0000256|RuleBase:RU000609}.
FT   DOMAIN          52..271
FT                   /note="Xylose isomerase-like TIM barrel"
FT                   /evidence="ECO:0000259|Pfam:PF01261"
SQ   SEQUENCE   329 AA;  36127 MW;  9A6DE6814D920E2E CRC64;
     MTATRFATRL NSFASRPQAE WPDLTGKPSL LQMAARAAKV GGLTDLDLNF PDHVSEKPAE
     IALKLSDLGL SINGFAMRYY SNPAFKLGAF TNPDPAVRRE AIDLTKAGID ALREAGASLM
     TLWLGQDGFD YAFQADYATL WQHEIDGIRE VSAHDPDCQI SLEYKPNEPR SYSLMPDAAT
     TLLAIRDVGV PNLGVTLDFA HVLYADEQPA FAAALVARHS KLLGVHLNDG YAKRDDGLMV
     GAVHTLQTIE LLRQIRRDGY AGAIYFDTFP DMTGLDPVRE CEVNIATVKR MLRVVDRLEQ
     DNRLSAAMDS QDAVTSQAII QEIMLGPDS
//