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E8T632

- E8T632_THEA1

UniProt

E8T632 - E8T632_THEA1

Protein

tRNA pseudouridine synthase A

Gene

truA

Organism
Thermovibrio ammonificans (strain DSM 15698 / JCM 12110 / HB-1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotationSAAS annotation

    Catalytic activityi

    tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei52 – 521NucleophileUniRule annotation
    Binding sitei110 – 1101SubstrateUniRule annotation

    GO - Molecular functioni

    1. pseudouridine synthase activity Source: UniProtKB-HAMAP
    2. RNA binding Source: InterPro

    GO - Biological processi

    1. tRNA pseudouridine synthesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Biological processi

    tRNA processingUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciTAMM648996:GI3X-665-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
    Alternative name(s):
    tRNA pseudouridine(38-40) synthaseUniRule annotation
    tRNA pseudouridylate synthase IUniRule annotation
    tRNA-uridine isomerase IUniRule annotation
    Gene namesi
    Name:truAUniRule annotation
    Ordered Locus Names:Theam_0646Imported
    OrganismiThermovibrio ammonificans (strain DSM 15698 / JCM 12110 / HB-1)Imported
    Taxonomic identifieri648996 [NCBI]
    Taxonomic lineageiBacteriaAquificaeDesulfurobacterialesDesulfurobacteriaceaeThermovibrio
    ProteomesiUP000006362: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000248673.
    KOiK06173.
    OMAiVYRITTH.

    Family and domain databases

    Gene3Di3.30.70.580. 1 hit.
    3.30.70.660. 1 hit.
    HAMAPiMF_00171. TruA.
    InterProiIPR020103. PsdUridine_synth_cat_dom.
    IPR001406. PsdUridine_synth_TruA.
    IPR020097. PsdUridine_synth_TruA_a/b_dom.
    IPR020095. PsdUridine_synth_TruA_C.
    IPR020094. PsdUridine_synth_TruA_N.
    [Graphical view]
    PANTHERiPTHR11142. PTHR11142. 1 hit.
    PfamiPF01416. PseudoU_synth_1. 2 hits.
    [Graphical view]
    PIRSFiPIRSF001430. tRNA_psdUrid_synth. 1 hit.
    SUPFAMiSSF55120. SSF55120. 1 hit.
    TIGRFAMsiTIGR00071. hisT_truA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E8T632-1 [UniParc]FASTAAdd to Basket

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    MRNFKLTVEY LGTNYYGWQF LPDKPTVQGE IIRCLETVLR HPVKLIGASR    50
    TDAGVHARGQ VANFLTAKEV SCEKLLSALN GLLPPDIRVK EVEEVPLEFH 100
    ARRSARGKLY RYRLFIRDVP SPFEFRRSWY LRRTLSVEPM REATQFLVGT 150
    HDFTTFSKSE RKREVNPIRT IDKIEITNKE WEEGVLVELL FTGRSFLRHM 200
    VRVIVATLVK VGTGEVKPQE VKEMLQAKDR SRAPFLAPPD GLYLERVFYD 250
    DYPY 254
    Length:254
    Mass (Da):29,564
    Last modified:April 5, 2011 - v1
    Checksum:i787DE70850FBB148
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002444 Genomic DNA. Translation: ADU96616.1.
    RefSeqiWP_013537402.1. NC_014926.1.
    YP_004151257.1. NC_014926.1.

    Genome annotation databases

    EnsemblBacteriaiADU96616; ADU96616; Theam_0646.
    GeneIDi10125683.
    KEGGitam:Theam_0646.
    PATRICi45383617. VBITheAmm13058_0742.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002444 Genomic DNA. Translation: ADU96616.1 .
    RefSeqi WP_013537402.1. NC_014926.1.
    YP_004151257.1. NC_014926.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADU96616 ; ADU96616 ; Theam_0646 .
    GeneIDi 10125683.
    KEGGi tam:Theam_0646.
    PATRICi 45383617. VBITheAmm13058_0742.

    Phylogenomic databases

    HOGENOMi HOG000248673.
    KOi K06173.
    OMAi VYRITTH.

    Enzyme and pathway databases

    BioCyci TAMM648996:GI3X-665-MONOMER.

    Family and domain databases

    Gene3Di 3.30.70.580. 1 hit.
    3.30.70.660. 1 hit.
    HAMAPi MF_00171. TruA.
    InterProi IPR020103. PsdUridine_synth_cat_dom.
    IPR001406. PsdUridine_synth_TruA.
    IPR020097. PsdUridine_synth_TruA_a/b_dom.
    IPR020095. PsdUridine_synth_TruA_C.
    IPR020094. PsdUridine_synth_TruA_N.
    [Graphical view ]
    PANTHERi PTHR11142. PTHR11142. 1 hit.
    Pfami PF01416. PseudoU_synth_1. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF001430. tRNA_psdUrid_synth. 1 hit.
    SUPFAMi SSF55120. SSF55120. 1 hit.
    TIGRFAMsi TIGR00071. hisT_truA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Thermovibrio ammonificans HB-1."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Vetriani C., Woyke T.
      Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 15698 / JCM 12110 / HB-1Imported.

    Entry informationi

    Entry nameiE8T632_THEA1
    AccessioniPrimary (citable) accession number: E8T632
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3