Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

tRNA pseudouridine synthase A

Gene

truA

Organism
Thermovibrio ammonificans (strain DSM 15698 / JCM 12110 / HB-1)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotationSAAS annotation

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei52 – 521NucleophileUniRule annotation
Binding sitei110 – 1101SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Biological processi

tRNA processingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciTAMM648996:GI3X-665-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
Alternative name(s):
tRNA pseudouridine(38-40) synthaseUniRule annotation
tRNA pseudouridylate synthase IUniRule annotation
tRNA-uridine isomerase IUniRule annotation
Gene namesi
Name:truAUniRule annotation
Ordered Locus Names:Theam_0646Imported
OrganismiThermovibrio ammonificans (strain DSM 15698 / JCM 12110 / HB-1)Imported
Taxonomic identifieri648996 [NCBI]
Taxonomic lineageiBacteriaAquificaeDesulfurobacterialesDesulfurobacteriaceaeThermovibrio
Proteomesi
  • UP000006362 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi648996.Theam_0646.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 10295PseudoU_synth_1InterPro annotationAdd
BLAST
Domaini143 – 250108PseudoU_synth_1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DI7. Bacteria.
COG0101. LUCA.
HOGENOMiHOG000248673.
KOiK06173.
OMAiIRTPIMA.

Family and domain databases

Gene3Di3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPiMF_00171. TruA.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view]
PANTHERiPTHR11142. PTHR11142. 1 hit.
PfamiPF01416. PseudoU_synth_1. 2 hits.
[Graphical view]
PIRSFiPIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00071. hisT_truA. 1 hit.

Sequencei

Sequence statusi: Complete.

E8T632-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNFKLTVEY LGTNYYGWQF LPDKPTVQGE IIRCLETVLR HPVKLIGASR
60 70 80 90 100
TDAGVHARGQ VANFLTAKEV SCEKLLSALN GLLPPDIRVK EVEEVPLEFH
110 120 130 140 150
ARRSARGKLY RYRLFIRDVP SPFEFRRSWY LRRTLSVEPM REATQFLVGT
160 170 180 190 200
HDFTTFSKSE RKREVNPIRT IDKIEITNKE WEEGVLVELL FTGRSFLRHM
210 220 230 240 250
VRVIVATLVK VGTGEVKPQE VKEMLQAKDR SRAPFLAPPD GLYLERVFYD

DYPY
Length:254
Mass (Da):29,564
Last modified:April 5, 2011 - v1
Checksum:i787DE70850FBB148
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002444 Genomic DNA. Translation: ADU96616.1.
RefSeqiWP_013537402.1. NC_014926.1.

Genome annotation databases

EnsemblBacteriaiADU96616; ADU96616; Theam_0646.
KEGGitam:Theam_0646.
PATRICi45383617. VBITheAmm13058_0742.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002444 Genomic DNA. Translation: ADU96616.1.
RefSeqiWP_013537402.1. NC_014926.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi648996.Theam_0646.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADU96616; ADU96616; Theam_0646.
KEGGitam:Theam_0646.
PATRICi45383617. VBITheAmm13058_0742.

Phylogenomic databases

eggNOGiENOG4105DI7. Bacteria.
COG0101. LUCA.
HOGENOMiHOG000248673.
KOiK06173.
OMAiIRTPIMA.

Enzyme and pathway databases

BioCyciTAMM648996:GI3X-665-MONOMER.

Family and domain databases

Gene3Di3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPiMF_00171. TruA.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view]
PANTHERiPTHR11142. PTHR11142. 1 hit.
PfamiPF01416. PseudoU_synth_1. 2 hits.
[Graphical view]
PIRSFiPIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00071. hisT_truA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Thermovibrio ammonificans HB-1."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Vetriani C., Woyke T.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15698 / JCM 12110 / HB-1Imported.

Entry informationi

Entry nameiE8T632_THEA1
AccessioniPrimary (citable) accession number: E8T632
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: May 11, 2016
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.