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E8T4G9

- E8T4G9_THEA1

UniProt

E8T4G9 - E8T4G9_THEA1

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Protein

Alanine racemase

Gene

Theam_0331

Organism
Thermovibrio ammonificans (strain DSM 15698 / JCM 12110 / HB-1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei33 – 331Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei126 – 1261SubstrateUniRule annotation
Active sitei248 – 2481Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei296 – 2961Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciTAMM648996:GI3X-344-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Theam_0331Imported
OrganismiThermovibrio ammonificans (strain DSM 15698 / JCM 12110 / HB-1)Imported
Taxonomic identifieri648996 [NCBI]
Taxonomic lineageiBacteriaAquificaeDesulfurobacterialesDesulfurobacteriaceaeThermovibrio
ProteomesiUP000006362: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE8T4G9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiYGHGLER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8T4G9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRWAEVHLD RLLYNYRQVE KLSGPKKLIA VVKANAYGHG SVAVARFLQE
60 70 80 90 100
QTAVSAFAVA TYAEGVQLRE AGIQRPIIVM SSTLEEELGR AREFRLMPVV
110 120 130 140 150
YDFWELERAK ELEVPFHVKL DTGMGRLGFL PSQWQELLCS LRGAKLAGVM
160 170 180 190 200
THFPSADEDP EFTAGQAKLF GEFVKALKGA FPKLWVHCDN SAALPLGLNG
210 220 230 240 250
LFTHSRVGLA LYGSKPFGGY PASLKQVMEV KARIISVKEL PPGHSVSYGR
260 270 280 290 300
TYTTSGKERV GVVSFGYADG LPRSLSGRGS FIVNGRRCPI RGRVCMDMTV
310 320 330 340 350
ISLEGVVAGK GGVATVTGLE LPFEELARLA GTIPYELMCR ISPRVERVYR

GLQSLRT
Length:357
Mass (Da):39,251
Last modified:April 5, 2011 - v1
Checksum:i0C2EE5793FB109D9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002444 Genomic DNA. Translation: ADU96304.1.
RefSeqiYP_004150945.1. NC_014926.1.

Genome annotation databases

EnsemblBacteriaiADU96304; ADU96304; Theam_0331.
GeneIDi10125362.
KEGGitam:Theam_0331.
PATRICi45382976. VBITheAmm13058_0427.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002444 Genomic DNA. Translation: ADU96304.1 .
RefSeqi YP_004150945.1. NC_014926.1.

3D structure databases

ProteinModelPortali E8T4G9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADU96304 ; ADU96304 ; Theam_0331 .
GeneIDi 10125362.
KEGGi tam:Theam_0331.
PATRICi 45382976. VBITheAmm13058_0427.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.
OMAi YGHGLER.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci TAMM648996:GI3X-344-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Thermovibrio ammonificans HB-1."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Vetriani C., Woyke T.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15698 / JCM 12110 / HB-1Imported.

Entry informationi

Entry nameiE8T4G9_THEA1
AccessioniPrimary (citable) accession number: E8T4G9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 29, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3