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Protein

Alanine racemase

Gene

Theam_0331

Organism
Thermovibrio ammonificans (strain DSM 15698 / JCM 12110 / HB-1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei33 – 331Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei126 – 1261SubstrateUniRule annotation
Active sitei248 – 2481Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei296 – 2961Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciTAMM648996:GI3X-344-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Theam_0331Imported
OrganismiThermovibrio ammonificans (strain DSM 15698 / JCM 12110 / HB-1)Imported
Taxonomic identifieri648996 [NCBI]
Taxonomic lineageiBacteriaAquificaeDesulfurobacterialesDesulfurobacteriaceaeThermovibrio
ProteomesiUP000006362: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE8T4G9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiWKGGAAI.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8T4G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRWAEVHLD RLLYNYRQVE KLSGPKKLIA VVKANAYGHG SVAVARFLQE
60 70 80 90 100
QTAVSAFAVA TYAEGVQLRE AGIQRPIIVM SSTLEEELGR AREFRLMPVV
110 120 130 140 150
YDFWELERAK ELEVPFHVKL DTGMGRLGFL PSQWQELLCS LRGAKLAGVM
160 170 180 190 200
THFPSADEDP EFTAGQAKLF GEFVKALKGA FPKLWVHCDN SAALPLGLNG
210 220 230 240 250
LFTHSRVGLA LYGSKPFGGY PASLKQVMEV KARIISVKEL PPGHSVSYGR
260 270 280 290 300
TYTTSGKERV GVVSFGYADG LPRSLSGRGS FIVNGRRCPI RGRVCMDMTV
310 320 330 340 350
ISLEGVVAGK GGVATVTGLE LPFEELARLA GTIPYELMCR ISPRVERVYR

GLQSLRT
Length:357
Mass (Da):39,251
Last modified:April 5, 2011 - v1
Checksum:i0C2EE5793FB109D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002444 Genomic DNA. Translation: ADU96304.1.
RefSeqiWP_013537090.1. NC_014926.1.
YP_004150945.1. NC_014926.1.

Genome annotation databases

EnsemblBacteriaiADU96304; ADU96304; Theam_0331.
GeneIDi10125362.
KEGGitam:Theam_0331.
PATRICi45382976. VBITheAmm13058_0427.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002444 Genomic DNA. Translation: ADU96304.1.
RefSeqiWP_013537090.1. NC_014926.1.
YP_004150945.1. NC_014926.1.

3D structure databases

ProteinModelPortaliE8T4G9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADU96304; ADU96304; Theam_0331.
GeneIDi10125362.
KEGGitam:Theam_0331.
PATRICi45382976. VBITheAmm13058_0427.

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiWKGGAAI.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciTAMM648996:GI3X-344-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Thermovibrio ammonificans HB-1."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Vetriani C., Woyke T.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15698 / JCM 12110 / HB-1Imported.

Entry informationi

Entry nameiE8T4G9_THEA1
AccessioniPrimary (citable) accession number: E8T4G9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 4, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.