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E8T4G9

- E8T4G9_THEA1

UniProt

E8T4G9 - E8T4G9_THEA1

Protein

Alanine racemase

Gene

Theam_0331

Organism
Thermovibrio ammonificans (strain DSM 15698 / JCM 12110 / HB-1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei33 – 331Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei126 – 1261SubstrateUniRule annotation
    Active sitei248 – 2481Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei296 – 2961Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciTAMM648996:GI3X-344-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Theam_0331Imported
    OrganismiThermovibrio ammonificans (strain DSM 15698 / JCM 12110 / HB-1)Imported
    Taxonomic identifieri648996 [NCBI]
    Taxonomic lineageiBacteriaAquificaeDesulfurobacterialesDesulfurobacteriaceaeThermovibrio
    ProteomesiUP000006362: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei33 – 331N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE8T4G9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiYGHGLER.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E8T4G9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRWAEVHLD RLLYNYRQVE KLSGPKKLIA VVKANAYGHG SVAVARFLQE    50
    QTAVSAFAVA TYAEGVQLRE AGIQRPIIVM SSTLEEELGR AREFRLMPVV 100
    YDFWELERAK ELEVPFHVKL DTGMGRLGFL PSQWQELLCS LRGAKLAGVM 150
    THFPSADEDP EFTAGQAKLF GEFVKALKGA FPKLWVHCDN SAALPLGLNG 200
    LFTHSRVGLA LYGSKPFGGY PASLKQVMEV KARIISVKEL PPGHSVSYGR 250
    TYTTSGKERV GVVSFGYADG LPRSLSGRGS FIVNGRRCPI RGRVCMDMTV 300
    ISLEGVVAGK GGVATVTGLE LPFEELARLA GTIPYELMCR ISPRVERVYR 350
    GLQSLRT 357
    Length:357
    Mass (Da):39,251
    Last modified:April 5, 2011 - v1
    Checksum:i0C2EE5793FB109D9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002444 Genomic DNA. Translation: ADU96304.1.
    RefSeqiYP_004150945.1. NC_014926.1.

    Genome annotation databases

    EnsemblBacteriaiADU96304; ADU96304; Theam_0331.
    GeneIDi10125362.
    KEGGitam:Theam_0331.
    PATRICi45382976. VBITheAmm13058_0427.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002444 Genomic DNA. Translation: ADU96304.1 .
    RefSeqi YP_004150945.1. NC_014926.1.

    3D structure databases

    ProteinModelPortali E8T4G9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADU96304 ; ADU96304 ; Theam_0331 .
    GeneIDi 10125362.
    KEGGi tam:Theam_0331.
    PATRICi 45382976. VBITheAmm13058_0427.

    Phylogenomic databases

    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi YGHGLER.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci TAMM648996:GI3X-344-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Thermovibrio ammonificans HB-1."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Vetriani C., Woyke T.
      Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 15698 / JCM 12110 / HB-1Imported.

    Entry informationi

    Entry nameiE8T4G9_THEA1
    AccessioniPrimary (citable) accession number: E8T4G9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3