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E8SYK9

- E8SYK9_GEOS2

UniProt

E8SYK9 - E8SYK9_GEOS2

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Protein

Segregation and condensation protein A

Gene

scpA

Organism
Geobacillus sp. (strain Y412MC52)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.UniRule annotationSAAS annotation

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. chromosome segregation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotationSAAS annotation, Chromosome partitionUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciGSP550542:GH52-2366-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Segregation and condensation protein AUniRule annotation
Gene namesi
Name:scpAUniRule annotation
Ordered Locus Names:GYMC52_2271Imported
OrganismiGeobacillus sp. (strain Y412MC52)Imported
Taxonomic identifieri550542 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000002223: Chromosome

Subcellular locationi

Cytoplasm SAAS annotation
Cytoplasm UniRule annotation
Note: Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.UniRule annotationSAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3W6JX-ray2.60A/D2-172[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ScpA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000242824.
KOiK05896.

Family and domain databases

HAMAPiMF_01805. ScpA.
InterProiIPR003768. ScpA.
[Graphical view]
PfamiPF02616. ScpA_ScpB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8SYK9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQLPYNVKIE AFEGPLDLLL HLINRYEIDI YDIPVAQITE QYMAYIHAMQ
60 70 80 90 100
ELELDIASEY LVMAATLLAI KSKMLLPPSN EEAVDGDIEW GDDGDPREEL
110 120 130 140 150
TQRLLEYKKF KEAARELKRR EEERALLFTK PPSDLSAYAD EKKAAPLDVN
160 170 180 190 200
VYDMLGALSK LLRRKKLQKP MRAKISRQDI SVEQRMAEIL HELKQANGRK
210 220 230 240
NFYELFPSYD RSYIVVTFLA ILELMKQDEI IVEQERNFSD LFLAVKPAG
Length:249
Mass (Da):28,885
Last modified:April 5, 2011 - v1
Checksum:i3215B4B478A515DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002442 Genomic DNA. Translation: ADU94673.1.
RefSeqiYP_004132816.1. NC_014915.1.

Genome annotation databases

EnsemblBacteriaiADU94673; ADU94673; GYMC52_2271.
GeneIDi10108969.
KEGGigya:GYMC52_2271.
PATRICi45226273. VBIGeoSp94955_2472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002442 Genomic DNA. Translation: ADU94673.1 .
RefSeqi YP_004132816.1. NC_014915.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3W6J X-ray 2.60 A/D 2-172 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADU94673 ; ADU94673 ; GYMC52_2271 .
GeneIDi 10108969.
KEGGi gya:GYMC52_2271.
PATRICi 45226273. VBIGeoSp94955_2472.

Phylogenomic databases

HOGENOMi HOG000242824.
KOi K05896.

Enzyme and pathway databases

BioCyci GSP550542:GH52-2366-MONOMER.

Family and domain databases

HAMAPi MF_01805. ScpA.
InterProi IPR003768. ScpA.
[Graphical view ]
Pfami PF02616. ScpA_ScpB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of chromosome of Geobacillus sp. Y412MC52."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Chertkov O., Munk C., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mead D., Woyke T.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y412MC52Imported.
  2. "Molecular basis of SMC ATPase activation: role of internal structural changes of the regulatory subcomplex ScpAB."
    Kamada K., Miyata M., Hirano T.
    Structure 21:581-594(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 2-172.

Entry informationi

Entry nameiE8SYK9_GEOS2
AccessioniPrimary (citable) accession number: E8SYK9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 1, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteomeImported

External Data

Dasty 3