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E8SYK9

- E8SYK9_GEOS2

UniProt

E8SYK9 - E8SYK9_GEOS2

Protein

Segregation and condensation protein A

Gene

scpA

Organism
Geobacillus sp. (strain Y412MC52)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.UniRule annotationSAAS annotation

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. chromosome segregation Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotationSAAS annotation, Chromosome partitionUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciGSP550542:GH52-2366-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Segregation and condensation protein AUniRule annotation
    Gene namesi
    Name:scpAUniRule annotation
    Ordered Locus Names:GYMC52_2271Imported
    OrganismiGeobacillus sp. (strain Y412MC52)Imported
    Taxonomic identifieri550542 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
    ProteomesiUP000002223: Chromosome

    Subcellular locationi

    Cytoplasm SAAS annotation
    Cytoplasm UniRule annotation
    Note: Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3W6JX-ray2.60A/D2-172[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ScpA family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000242824.
    KOiK05896.

    Family and domain databases

    HAMAPiMF_01805. ScpA.
    InterProiIPR003768. ScpA.
    [Graphical view]
    PfamiPF02616. ScpA_ScpB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E8SYK9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQLPYNVKIE AFEGPLDLLL HLINRYEIDI YDIPVAQITE QYMAYIHAMQ    50
    ELELDIASEY LVMAATLLAI KSKMLLPPSN EEAVDGDIEW GDDGDPREEL 100
    TQRLLEYKKF KEAARELKRR EEERALLFTK PPSDLSAYAD EKKAAPLDVN 150
    VYDMLGALSK LLRRKKLQKP MRAKISRQDI SVEQRMAEIL HELKQANGRK 200
    NFYELFPSYD RSYIVVTFLA ILELMKQDEI IVEQERNFSD LFLAVKPAG 249
    Length:249
    Mass (Da):28,885
    Last modified:April 5, 2011 - v1
    Checksum:i3215B4B478A515DB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002442 Genomic DNA. Translation: ADU94673.1.
    RefSeqiYP_004132816.1. NC_014915.1.

    Genome annotation databases

    EnsemblBacteriaiADU94673; ADU94673; GYMC52_2271.
    GeneIDi10108969.
    KEGGigya:GYMC52_2271.
    PATRICi45226273. VBIGeoSp94955_2472.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002442 Genomic DNA. Translation: ADU94673.1 .
    RefSeqi YP_004132816.1. NC_014915.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3W6J X-ray 2.60 A/D 2-172 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADU94673 ; ADU94673 ; GYMC52_2271 .
    GeneIDi 10108969.
    KEGGi gya:GYMC52_2271.
    PATRICi 45226273. VBIGeoSp94955_2472.

    Phylogenomic databases

    HOGENOMi HOG000242824.
    KOi K05896.

    Enzyme and pathway databases

    BioCyci GSP550542:GH52-2366-MONOMER.

    Family and domain databases

    HAMAPi MF_01805. ScpA.
    InterProi IPR003768. ScpA.
    [Graphical view ]
    Pfami PF02616. ScpA_ScpB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Geobacillus sp. Y412MC52."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Chertkov O., Munk C., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mead D., Woyke T.
      Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Y412MC52Imported.
    2. "Molecular basis of SMC ATPase activation: role of internal structural changes of the regulatory subcomplex ScpAB."
      Kamada K., Miyata M., Hirano T.
      Structure 21:581-594(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 2-172.

    Entry informationi

    Entry nameiE8SYK9_GEOS2
    AccessioniPrimary (citable) accession number: E8SYK9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3