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E8SYK8

- E8SYK8_GEOS2

UniProt

E8SYK8 - E8SYK8_GEOS2

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Protein
Segregation and condensation protein B
Gene
scpB, GYMC52_2270
Organism
Geobacillus sp. (strain Y412MC52)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves By similarity.UniRule annotationSAAS annotations

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. chromosome separation Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotationSAAS annotations, Chromosome partitionUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciGSP550542:GH52-2365-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Segregation and condensation protein BUniRule annotation
Gene namesi
Name:scpBUniRule annotation
Ordered Locus Names:GYMC52_2270Imported
OrganismiGeobacillus sp. (strain Y412MC52)Imported
Taxonomic identifieri550542 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000002223: Chromosome

Subcellular locationi

Cytoplasm By similarity SAAS annotations
Cytoplasm
Note: Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells By similarity.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homodimer. Homodimerization may be required to stabilize the binding of ScpA to the Smc head domains. Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA By similarity.UniRule annotationSAAS annotations

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3W6JX-ray2.60B/C/E/F68-247[»]
3W6KX-ray2.37B/C/E/F68-155[»]

Family & Domainsi

Sequence similaritiesi

Belongs to the ScpB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000242838.
KOiK06024.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
HAMAPiMF_01804. ScpB.
InterProiIPR005234. ScpB_csome_segregation.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF04079. DUF387. 1 hit.
[Graphical view]
PIRSFiPIRSF019345. ScpB. 1 hit.
TIGRFAMsiTIGR00281. TIGR00281. 1 hit.

Sequencei

Sequence statusi: Complete.

E8SYK8-1 [UniParc]FASTAAdd to Basket

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MAAAVRCGGP LFFCCLFAHA MIRRRVDSHW GEKTWETTKT GGKEEGRQRV    50
WRGRRAMEQN EREKKGAGAL KPAKAIVEAL LFAAGDEGLS LSQIAAVLEV 100
SELEAKAVIE ELQQDCRREE RGIQLVELGG VFLLATKKEH APYLKKLVEA 150
PGASPLSQAA LETLAIIAYR QPITRAEIEE IRGVKSDKPL QTLMARALIK 200
EVGRAEGTGR PILYGTTPEF LDYFGLKTLE ELPPLPEWAD DGESEREADL 250
FFEKLAENLS DGQPEYGKLK KNG 273
Length:273
Mass (Da):30,247
Last modified:April 5, 2011 - v1
Checksum:iDA927D893B632927
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002442 Genomic DNA. Translation: ADU94672.1.
RefSeqiYP_004132815.1. NC_014915.1.

Genome annotation databases

EnsemblBacteriaiADU94672; ADU94672; GYMC52_2270.
GeneIDi10108968.
KEGGigya:GYMC52_2270.
PATRICi45226271. VBIGeoSp94955_2471.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002442 Genomic DNA. Translation: ADU94672.1 .
RefSeqi YP_004132815.1. NC_014915.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3W6J X-ray 2.60 B/C/E/F 68-247 [» ]
3W6K X-ray 2.37 B/C/E/F 68-155 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADU94672 ; ADU94672 ; GYMC52_2270 .
GeneIDi 10108968.
KEGGi gya:GYMC52_2270.
PATRICi 45226271. VBIGeoSp94955_2471.

Phylogenomic databases

HOGENOMi HOG000242838.
KOi K06024.

Enzyme and pathway databases

BioCyci GSP550542:GH52-2365-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 2 hits.
HAMAPi MF_01804. ScpB.
InterProi IPR005234. ScpB_csome_segregation.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF04079. DUF387. 1 hit.
[Graphical view ]
PIRSFi PIRSF019345. ScpB. 1 hit.
TIGRFAMsi TIGR00281. TIGR00281. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of chromosome of Geobacillus sp. Y412MC52."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Chertkov O., Munk C., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mead D., Woyke T.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y412MC52Imported.
  2. "Molecular basis of SMC ATPase activation: role of internal structural changes of the regulatory subcomplex ScpAB."
    Kamada K., Miyata M., Hirano T.
    Structure 21:581-594(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.37 ANGSTROMS) OF 68-155.

Entry informationi

Entry nameiE8SYK8_GEOS2
AccessioniPrimary (citable) accession number: E8SYK8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: February 19, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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