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E8SYK8

- E8SYK8_GEOS2

UniProt

E8SYK8 - E8SYK8_GEOS2

Protein

Segregation and condensation protein B

Gene

scpB

Organism
Geobacillus sp. (strain Y412MC52)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.UniRule annotationSAAS annotation

    GO - Biological processi

    1. cell division Source: UniProtKB-KW
    2. chromosome separation Source: InterPro

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotationSAAS annotation, Chromosome partitionUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciGSP550542:GH52-2365-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Segregation and condensation protein BUniRule annotation
    Gene namesi
    Name:scpBUniRule annotation
    Ordered Locus Names:GYMC52_2270Imported
    OrganismiGeobacillus sp. (strain Y412MC52)Imported
    Taxonomic identifieri550542 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
    ProteomesiUP000002223: Chromosome

    Subcellular locationi

    Cytoplasm SAAS annotation
    Cytoplasm UniRule annotation
    Note: Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homodimer. Homodimerization may be required to stabilize the binding of ScpA to the Smc head domains. Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3W6JX-ray2.60B/C/E/F68-247[»]
    3W6KX-ray2.37B/C/E/F68-155[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ScpB family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000242838.
    KOiK06024.

    Family and domain databases

    Gene3Di1.10.10.10. 2 hits.
    HAMAPiMF_01804. ScpB.
    InterProiIPR005234. ScpB_csome_segregation.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF04079. DUF387. 1 hit.
    [Graphical view]
    PIRSFiPIRSF019345. ScpB. 1 hit.
    TIGRFAMsiTIGR00281. TIGR00281. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E8SYK8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAVRCGGP LFFCCLFAHA MIRRRVDSHW GEKTWETTKT GGKEEGRQRV    50
    WRGRRAMEQN EREKKGAGAL KPAKAIVEAL LFAAGDEGLS LSQIAAVLEV 100
    SELEAKAVIE ELQQDCRREE RGIQLVELGG VFLLATKKEH APYLKKLVEA 150
    PGASPLSQAA LETLAIIAYR QPITRAEIEE IRGVKSDKPL QTLMARALIK 200
    EVGRAEGTGR PILYGTTPEF LDYFGLKTLE ELPPLPEWAD DGESEREADL 250
    FFEKLAENLS DGQPEYGKLK KNG 273
    Length:273
    Mass (Da):30,247
    Last modified:April 5, 2011 - v1
    Checksum:iDA927D893B632927
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002442 Genomic DNA. Translation: ADU94672.1.
    RefSeqiYP_004132815.1. NC_014915.1.

    Genome annotation databases

    EnsemblBacteriaiADU94672; ADU94672; GYMC52_2270.
    GeneIDi10108968.
    KEGGigya:GYMC52_2270.
    PATRICi45226271. VBIGeoSp94955_2471.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002442 Genomic DNA. Translation: ADU94672.1 .
    RefSeqi YP_004132815.1. NC_014915.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3W6J X-ray 2.60 B/C/E/F 68-247 [» ]
    3W6K X-ray 2.37 B/C/E/F 68-155 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADU94672 ; ADU94672 ; GYMC52_2270 .
    GeneIDi 10108968.
    KEGGi gya:GYMC52_2270.
    PATRICi 45226271. VBIGeoSp94955_2471.

    Phylogenomic databases

    HOGENOMi HOG000242838.
    KOi K06024.

    Enzyme and pathway databases

    BioCyci GSP550542:GH52-2365-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 2 hits.
    HAMAPi MF_01804. ScpB.
    InterProi IPR005234. ScpB_csome_segregation.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF04079. DUF387. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF019345. ScpB. 1 hit.
    TIGRFAMsi TIGR00281. TIGR00281. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Geobacillus sp. Y412MC52."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Chertkov O., Munk C., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mead D., Woyke T.
      Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Y412MC52Imported.
    2. "Molecular basis of SMC ATPase activation: role of internal structural changes of the regulatory subcomplex ScpAB."
      Kamada K., Miyata M., Hirano T.
      Structure 21:581-594(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.37 ANGSTROMS) OF 68-155.

    Entry informationi

    Entry nameiE8SYK8_GEOS2
    AccessioniPrimary (citable) accession number: E8SYK8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3