E8SWG3 (E8SWG3_GEOS2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase PrpE [asymmetrical] HAMAP-Rule MF_01443
EC=3.6.1.17 HAMAP-Rule MF_01443

Alternative name(s):
Ap4A hydrolase HAMAP-Rule MF_01443
Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase HAMAP-Rule MF_01443

Gene names

Name:	prpE HAMAP-Rule MF_01443
Ordered Locus Names:	GYMC52_0757 EMBL ADU93241.1

Organism

Geobacillus sp. (strain Y412MC52) [Complete proteome] [HAMAP] EMBL ADU93241.1

Taxonomic identifier

550542 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length	245 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Asymmetrically hydrolyzes Ap4p to yield AMP and ATP By similarity. HAMAP-Rule MF_01443
Catalytic activity	P1,P(4)-bis(5'-guanosyl) tetraphosphate + H2O = GTP + GMP. HAMAP-Rule MF_01443
Cofactor	Nickel By similarity. HAMAP-Rule MF_01443
Sequence similarities	Belongs to the PrpE family. HAMAP-Rule MF_01443

Ontologies

Keywords
Ligand	GTP-binding HAMAP-Rule MF_01443 Nickel HAMAP-Rule MF_01443 Nucleotide-binding
Molecular function	Hydrolase HAMAP-Rule MF_01443 EMBL ADU93241.1
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity Inferred from electronic annotation. Source: HAMAP nickel cation binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E8SWG3 [UniParc]. Last modified April 5, 2011. Version 1. Checksum: B80B4C5473EDA37A	FASTA	245	27,764
	10 20 30 40 50 60 MQVDIIGDIH GCFREFAALT ETLGYHWDEG VPIHPDGRKL GFVGDLTDRG PESLNMIEIV 70 80 90 100 110 120 CALVERNLAY YVPGNHCNKL YRFFLGRNVQ IAHGLETTVA EYRSLPPSEQ EMIRRKFIRL 130 140 150 160 170 180 YEQAPLYAVL DEGRLVIAHA GIRHDYIGRT DKKVKTFVLY GDITGETNPD GTPVRRDWAK 190 200 210 220 230 240 RYHGSAWVVY GHTPVEKPRF VGRTVNIDTG CVFGGALTAL RYPEMETVSV PSSMPFVPEK FRTFS

References

[1]

"Complete sequence of chromosome of Geobacillus sp. Y412MC52." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Chertkov O., Munk C., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mead D., Woyke T. Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Y412MC52 EMBL ADU93241.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002442 Genomic DNA. Translation: ADU93241.1.
RefSeq	YP_004131384.1. NC_014915.1.
3D structure databases
ProteinModelPortal	E8SWG3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADU93241; ADU93241; GYMC52_0757.
GeneID	10107434.
KEGG	gya:GYMC52_0757.
PATRIC	45222866. VBIGeoSp94955_0809.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000251870.
KO	K01090.
Enzyme and pathway databases
BioCyc	GSP550542:GH52-873-MONOMER.
Family and domain databases
HAMAP	MF_01443. PrpE.
InterPro	IPR023937. Bis(5'-nucleosyl)-tetraP_PrpE. IPR004843. Metallo_PEstase_dom. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

E8SWG3_GEOS2

Accession

Primary (citable) accession number: E8SWG3

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	May 1, 2013
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)