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E8SQM3

- E8SQM3_NEIGO

UniProt

E8SQM3 - E8SQM3_NEIGO

Protein

Alanine racemase

Gene

NGTW08_1189

Organism
Neisseria gonorrhoeae TCDC-NG08107
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei33 – 331Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei129 – 1291SubstrateUniRule annotation
    Active sitei250 – 2501Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei298 – 2981Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciNGON940296:GLHN-1196-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    ORF Names:NGTW08_1189Imported
    OrganismiNeisseria gonorrhoeae TCDC-NG08107
    Taxonomic identifieri940296 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei33 – 331N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE8SQM3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E8SQM3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPLNVQIRL GNLRHNYRIL KEMHGGKLLA VVKADAYGHG AVRCAFALAD    50
    LADGFAVATI DEGIRLRESG ITHPIVLLEG VFEASEYEAV EQYSLWPAVG 100
    NQWQLEALLS RHWKKPVKVW LKMDSGMHRT GFFPHDYASA YAALKQSEYV 150
    DSIVKFSHFS CADEPESGMT EIQMEAFDLG TKGLEGEESL ANSAAILNIP 200
    EARRDWGRAG LALYGISPFG GNDDRLKPVM RLSTRIFGER VLQPHSPIGY 250
    GATFYTSKST RVGLIACGYA DGYPRRAPSN SPVAVDGKLT RVIGRISMDM 300
    MTIELDASQE GLGHEVELWG DTVNINTVAE AAGTIPYELM CNIKRAKFTY 350
    IE 352
    Length:352
    Mass (Da):38,874
    Last modified:April 5, 2011 - v1
    Checksum:i434CED1AF8C1359D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002440 Genomic DNA. Translation: ADV08157.1.
    RefSeqiWP_014580279.1. NC_017511.1.
    YP_005890020.1. NC_017511.1.

    Genome annotation databases

    EnsemblBacteriaiADV08157; ADV08157; NGTW08_1189.
    GeneIDi12406483.
    KEGGingt:NGTW08_1189.
    PATRICi45471860. VBINeiGon174987_1474.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002440 Genomic DNA. Translation: ADV08157.1 .
    RefSeqi WP_014580279.1. NC_017511.1.
    YP_005890020.1. NC_017511.1.

    3D structure databases

    ProteinModelPortali E8SQM3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADV08157 ; ADV08157 ; NGTW08_1189 .
    GeneIDi 12406483.
    KEGGi ngt:NGTW08_1189.
    PATRICi 45471860. VBINeiGon174987_1474.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci NGON940296:GLHN-1196-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Chen C.-C., Hsia K.-C., Huang C.-T., Wong W.-W., Yen M.-Y., Li L.-H., Lin K.-Y., Chen K.-W., Li S.-Y.
      Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: TCDC-NG08107Imported.
    2. "Draft genome sequence of a dominant, multidrug-resistant Neisseria gonorrhoeae strain, TCDC-NG08107, from a sexual group at high risk of acquiring human immunodeficiency virus infection and syphilis."
      Chen C.C., Hsia K.C., Huang C.T., Wong W.W., Yen M.Y., Li L.H., Lin K.Y., Chen K.W., Li S.Y.
      J. Bacteriol. 193:1788-1789(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TCDC-NG08107Imported.

    Entry informationi

    Entry nameiE8SQM3_NEIGO
    AccessioniPrimary (citable) accession number: E8SQM3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)