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E8SQM3

- E8SQM3_NEIGO

UniProt

E8SQM3 - E8SQM3_NEIGO

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Protein

Alanine racemase

Gene
NGTW08_1189
Organism
Neisseria gonorrhoeae TCDC-NG08107
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei33 – 331Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei129 – 1291Substrate By similarityUniRule annotation
Active sitei250 – 2501Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei298 – 2981Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciNGON940296:GLHN-1196-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
ORF Names:NGTW08_1189Imported
OrganismiNeisseria gonorrhoeae TCDC-NG08107Imported
Taxonomic identifieri940296 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000007470: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE8SQM3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8SQM3-1 [UniParc]FASTAAdd to Basket

« Hide

MRPLNVQIRL GNLRHNYRIL KEMHGGKLLA VVKADAYGHG AVRCAFALAD    50
LADGFAVATI DEGIRLRESG ITHPIVLLEG VFEASEYEAV EQYSLWPAVG 100
NQWQLEALLS RHWKKPVKVW LKMDSGMHRT GFFPHDYASA YAALKQSEYV 150
DSIVKFSHFS CADEPESGMT EIQMEAFDLG TKGLEGEESL ANSAAILNIP 200
EARRDWGRAG LALYGISPFG GNDDRLKPVM RLSTRIFGER VLQPHSPIGY 250
GATFYTSKST RVGLIACGYA DGYPRRAPSN SPVAVDGKLT RVIGRISMDM 300
MTIELDASQE GLGHEVELWG DTVNINTVAE AAGTIPYELM CNIKRAKFTY 350
IE 352
Length:352
Mass (Da):38,874
Last modified:April 5, 2011 - v1
Checksum:i434CED1AF8C1359D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002440 Genomic DNA. Translation: ADV08157.1.
RefSeqiWP_014580279.1. NC_017511.1.
YP_005890020.1. NC_017511.1.

Genome annotation databases

EnsemblBacteriaiADV08157; ADV08157; NGTW08_1189.
GeneIDi12406483.
KEGGingt:NGTW08_1189.
PATRICi45471860. VBINeiGon174987_1474.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002440 Genomic DNA. Translation: ADV08157.1 .
RefSeqi WP_014580279.1. NC_017511.1.
YP_005890020.1. NC_017511.1.

3D structure databases

ProteinModelPortali E8SQM3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADV08157 ; ADV08157 ; NGTW08_1189 .
GeneIDi 12406483.
KEGGi ngt:NGTW08_1189.
PATRICi 45471860. VBINeiGon174987_1474.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci NGON940296:GLHN-1196-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Draft genome sequence of a dominant, multidrug-resistant Neisseria gonorrhoeae strain, TCDC-NG08107, from a sexual group at high risk of acquiring human immunodeficiency virus infection and syphilis."
    Chen C.C., Hsia K.C., Huang C.T., Wong W.W., Yen M.Y., Li L.H., Lin K.Y., Chen K.W., Li S.Y.
    J. Bacteriol. 193:1788-1789(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TCDC-NG08107Imported.

Entry informationi

Entry nameiE8SQM3_NEIGO
AccessioniPrimary (citable) accession number: E8SQM3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 3, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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