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E8SDY6

- E8SDY6_STAPH

UniProt

E8SDY6 - E8SDY6_STAPH

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Protein
Thymidine kinase
Gene
tdk, SPSINT_1781
Organism
Staphylococcus pseudintermedius (strain HKU10-03)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Proton acceptor By similarityUniRule annotation
Metal bindingi145 – 1451Zinc By similarityUniRule annotation
Metal bindingi148 – 1481Zinc By similarityUniRule annotation
Metal bindingi183 – 1831Zinc By similarityUniRule annotation
Metal bindingi186 – 1861Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228ATP By similarityUniRule annotation
Nucleotide bindingi88 – 914ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciSPSE937773:GH0P-1849-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:SPSINT_1781Imported
OrganismiStaphylococcus pseudintermedius (strain HKU10-03)Imported
Taxonomic identifieri937773 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000007469: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000076390.
KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8SDY6-1 [UniParc]FASTAAdd to Basket

« Hide

MYEAYHSGWI ECITGSMFSG KSEELIRRLR RGVYAKQKVV VFKPTIDDRY    50
HKEKIVSHNG NEIEAINISK ASEIWRHDLN GVDIIGIDEI QFFDRDIVDI 100
AQTLAERGYR VITAGLDMDF KGEPFHPVPE MLAVSEHITK LQAVCAVCGA 150
SSSRTQRLID GKPAKVDDPI ILVGANESYE PRCRAHHIVA PSENDKEALE 200
Length:200
Mass (Da):22,506
Last modified:April 5, 2011 - v1
Checksum:iCC05A83FC9BA10EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002439 Genomic DNA. Translation: ADV06309.1.
RefSeqiYP_004149945.1. NC_014925.1.

Genome annotation databases

EnsemblBacteriaiADV06309; ADV06309; SPSINT_1781.
GeneIDi10136588.
KEGGissd:SPSINT_1781.
PATRICi45366848. VBIStaPse177932_1780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002439 Genomic DNA. Translation: ADV06309.1 .
RefSeqi YP_004149945.1. NC_014925.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADV06309 ; ADV06309 ; SPSINT_1781 .
GeneIDi 10136588.
KEGGi ssd:SPSINT_1781.
PATRICi 45366848. VBIStaPse177932_1780.

Phylogenomic databases

HOGENOMi HOG000076390.
KOi K00857.

Enzyme and pathway databases

BioCyci SPSE937773:GH0P-1849-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Staphylococcus pseudintermedius."
    Tse H., Tsoi H.W., Leung S.P., Urquhart I.J., Lau S.K.P., Woo P.C.Y., Yuen K.Y.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HKU10-03.
  2. "Complete genome sequence of the veterinary pathogen Staphylococcus pseudintermedius strain HKU10-03, isolated in a case of canine pyoderma."
    Tse H., Tsoi H.W., Leung S.P., Urquhart I.J., Lau S.K., Woo P.C., Yuen K.Y.
    J. Bacteriol. 193:1783-1784(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HKU10-03Imported.

Entry informationi

Entry nameiE8SDY6_STAPH
AccessioniPrimary (citable) accession number: E8SDY6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 11, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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