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E8S698

- E8S698_MICSL

UniProt

E8S698 - E8S698_MICSL

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Protein

D-alanine--D-alanine ligase

Gene
ddl, ML5_6251
Organism
Micromonospora sp. (strain L5)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotations

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi278 – 2781Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi291 – 2911Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi291 – 2911Magnesium or manganese 2 By similarityUniRule annotation
Metal bindingi293 – 2931Magnesium or manganese 2 By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi151 – 20656ATP By similarityUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  2. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSP648999:GHVN-6317-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:ML5_6251Imported
OrganismiMicromonospora sp. (strain L5)Imported
Taxonomic identifieri648999 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeMicromonospora
ProteomesiUP000008685: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliE8S698.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini117 – 324208ATP-grasp By similarityUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotations

Phylogenomic databases

HOGENOMiHOG000011592.
KOiK01921.
OMAiGCDARSS.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8S698-1 [UniParc]FASTAAdd to Basket

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MSDSPAAPPP VTGSAADELH VLVLAGGLSY ERDVSLRSGR RVLDALRAVG    50
VDAELRDADV ALLPALTADP PDAVVIALHG ATGEDGSLRG VLDLWDVPYV 100
GCDARSSRLA WDKPSAKAVL REAGIPTPDW VALPHDRFSE LGAVAVLDRI 150
VDRLGLPLMV KPAQGGSGLG AAVVREAASL PAAMVGCFAY DQTALVERYV 200
PGMDVAVSVL DLGKGPQALP PVEIVPRNGV YDYAARYTAG RTTWHAPARL 250
DAATTARVTE VALAAHTALG LRDVSRVDLI VDAGGDPHVL EVNVSPGMTE 300
TSLLPLAIQA AGLDFGRVLG TLVTRAAARR R 331
Length:331
Mass (Da):34,465
Last modified:April 5, 2011 - v1
Checksum:iF8FF0E684E3DB49A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002399 Genomic DNA. Translation: ADU11694.1.
RefSeqiWP_013477531.1. NC_014815.1.
YP_004085845.1. NC_014815.1.

Genome annotation databases

EnsemblBacteriaiADU11694; ADU11694; ML5_6251.
GeneIDi10061790.
KEGGimil:ML5_6251.
PATRICi45280530. VBIMicSp154089_6274.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002399 Genomic DNA. Translation: ADU11694.1 .
RefSeqi WP_013477531.1. NC_014815.1.
YP_004085845.1. NC_014815.1.

3D structure databases

ProteinModelPortali E8S698.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADU11694 ; ADU11694 ; ML5_6251 .
GeneIDi 10061790.
KEGGi mil:ML5_6251.
PATRICi 45280530. VBIMicSp154089_6274.

Phylogenomic databases

HOGENOMi HOG000011592.
KOi K01921.
OMAi GCDARSS.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci MSP648999:GHVN-6317-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: L5.

Entry informationi

Entry nameiE8S698_MICSL
AccessioniPrimary (citable) accession number: E8S698
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 3, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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