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E8S4M2 (E8S4M2_MICSL) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphofructokinase HAMAP-Rule MF_00339

Short name=Phosphofructokinase HAMAP-Rule MF_00339
EC=2.7.1.11 HAMAP-Rule MF_00339
Alternative name(s):
Phosphohexokinase HAMAP-Rule MF_00339
Gene names
Name:pfkA HAMAP-Rule MF_00339
Ordered Locus Names:ML5_3770 EMBL ADU09281.1
OrganismMicromonospora sp. (strain L5) [Complete proteome] [HAMAP] EMBL ADU09281.1
Taxonomic identifier648999 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeMicromonospora

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. HAMAP-Rule MF_00339

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. HAMAP-Rule MF_00339

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00339.

Sequence similarities

Belongs to the phosphofructokinase family. HAMAP-Rule MF_00339

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding20 – 245ATP By similarity HAMAP-Rule MF_00339
Nucleotide binding154 – 1585ATP By similarity HAMAP-Rule MF_00339
Nucleotide binding171 – 18717ATP By similarity HAMAP-Rule MF_00339

Sites

Active site1271Proton acceptor By similarity HAMAP-Rule MF_00339
Binding site1621Substrate By similarity HAMAP-Rule MF_00339
Binding site2651Substrate By similarity HAMAP-Rule MF_00339
Binding site2711Substrate By similarity HAMAP-Rule MF_00339
Binding site2741Substrate By similarity HAMAP-Rule MF_00339

Sequences

Sequence LengthMass (Da)Tools
E8S4M2 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: D5A464A776A12D96

FASTA34236,542
        10         20         30         40         50         60 
MRIGVLTGGG DCPGLNAVIR AVVRKGVATY GHEFVGFRDG WKGPLEGLTK PLGIAEVRGI 

        70         80         90        100        110        120 
LPRGGTILGS SRTNPFKIEN GVERIKDNLA AQGVDALIAI GGEDTLGVAT KLHELGVNVI 

       130        140        150        160        170        180 
GVPKTIDNDL GATDYTFGFD TAVNIAMEAI DRLHTTAESH HRTLVVEVMG RHAGWIALHA 

       190        200        210        220        230        240 
GLAGGANVIL LPERQFDVEQ VAGYVEKRFQ HQYAPIVVVA EGAQPLDGQT VLHNQELDAF 

       250        260        270        280        290        300 
GHVRLGGIGQ WLAEQLEAKT GKEARTVVLG HIQRGGTPTA FDRVLATRLG LHAIDAAHEG 

       310        320        330        340 
DWGKMVAMQS TDIVRVPLAD ATRELKTVPL ERYAEAEVFF GS 

« Hide

References

[1]"Complete sequence of Micromonospora sp. L5."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Saunders E., Detter J.C., Han C., Tapia R., Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N., Ovchinnikova G., De Hoff P.L., Hirsch A.M., Woyke T.
Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: L5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002399 Genomic DNA. Translation: ADU09281.1.
RefSeqYP_004083432.1. NC_014815.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADU09281; ADU09281; ML5_3770.
GeneID10059298.
KEGGmil:ML5_3770.
PATRIC45275521. VBIMicSp154089_3796.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000248869.
KOK00850.
OMAIPEIPYK.

Enzyme and pathway databases

BioCycMSP648999:GHVN-3825-MONOMER.
UniPathwayUPA00109; UER00182.

Family and domain databases

HAMAPMF_00339. Phosphofructokinase.
InterProIPR012003. ATP_PFK_prok.
IPR012829. PFK.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamPF00365. PFK. 1 hit.
[Graphical view]
PIRSFPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSPR00476. PHFRCTKINASE.
SUPFAMSSF53784. SSF53784. 1 hit.
TIGRFAMsTIGR02483. PFK_mixed. 1 hit.
PROSITEPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE8S4M2_MICSL
AccessionPrimary (citable) accession number: E8S4M2
Entry history
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: April 16, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)