E8S4E1 (E8S4E1_MICSL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Aspartokinase RuleBase RU003448
EC=2.7.2.4 RuleBase RU003448

Gene names

Ordered Locus Names:

ML5_2556

Organism

Micromonospora sp. (strain L5) [Complete proteome] [HAMAP] EMBL ADU08078.1

Taxonomic identifier

648999 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Micromonospora

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-aspartate = ADP + 4-phospho-L-aspartate. RuleBase RU003448
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4. Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3. Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.
Sequence similarities	Belongs to the aspartokinase family. RuleBase RU003448

Ontologies

Keywords
Biological process	Amino-acid biosynthesis RuleBase RU004249
Molecular function	Kinase RuleBase RU003448 EMBL ADU08078.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lysine biosynthetic process via diaminopimelate Inferred from electronic annotation. Source: UniProtKB-UniPathway threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E8S4E1 [UniParc]. Last modified April 5, 2011. Version 1. Checksum: 8F2040F9E23DCE2B	FASTA	421	44,016
	10 20 30 40 50 60 MALVVQKYGG SSVANAERIK RVAERIVAAR KAGDDVVVVV SAMGDTTDEL LDLANQVSPL 70 80 90 100 110 120 PPGRELDMLL TAGERISMAL LAMAIHNLGY EARSFTGSQA GVITTSVHGR ARIIDVTPGR 130 140 150 160 170 180 LKGALDEGAV VIVAGFQGVS QDTKDVTTLG RGGSDTTAVA LAAALEADVC EIYTDVDGIF 190 200 210 220 230 240 TADPRIVPNA RHIKQITYEE MLELAACGAK VLHLRSVEYA RRAGLPIHVR SSYSTNTGTM 250 260 270 280 290 300 VTGSMEDLPV EQALITGVAH DRSEAKITIV GVPDEPGAAA SIFDTVAGAE INIDMIVQNV 310 320 330 340 350 360 STEGTGRTDI SFTLPKADGP TAMTALSKIQ ESVKFKGLLY DDHVGKVSLI GAGMRSHPGV 370 380 390 400 410 420 AAGFFAALGA AGVNIEMIST SEIRVSVVCR DTDLDKAVRA IHDAFELGGD TEAVVYAGTG R

References

[1]

"Complete sequence of Micromonospora sp. L5." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Saunders E., Detter J.C., Han C., Tapia R., Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N., Ovchinnikova G., De Hoff P.L., Hirsch A.M., Woyke T. Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: L5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002399 Genomic DNA. Translation: ADU08078.1.
RefSeq	YP_004082229.1. NC_014815.1.
3D structure databases
ProteinModelPortal	E8S4E1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADU08078; ADU08078; ML5_2556.
GeneID	10058068.
KEGG	mil:ML5_2556.
PATRIC	45273029. VBIMicSp154089_2573.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000293093.
KO	K00928.
OMA	SVDMIIQ.
Enzyme and pathway databases
BioCyc	MSP648999:GHVN-2594-MONOMER.
UniPathway	UPA00034; UER00015. UPA00050; UER00461. UPA00051; UER00462.
Family and domain databases
Gene3D	3.40.1160.10. 1 hit.
InterPro	IPR002912. ACT_dom. IPR001048. Asp/Glu/Uridylate_kinase. IPR005260. Asp_kin_monofn. IPR001341. Asp_kinase_dom. IPR018042. Aspartate_kinase_CS. [Graphical view]
Pfam	PF00696. AA_kinase. 1 hit. PF01842. ACT. 1 hit. [Graphical view]
PIRSF	PIRSF000726. Asp_kin. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00656. asp_kin_monofn. 1 hit. TIGR00657. asp_kinases. 1 hit.
PROSITE	PS00324. ASPARTOKINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

E8S4E1_MICSL

Accession

Primary (citable) accession number: E8S4E1

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	May 1, 2013
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)