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Protein

D-alanine--D-alanine ligase

Gene

Astex_1862

Organism
Asticcacaulis excentricus (strain ATCC 15261 / DSM 4724 / VKM B-1370 / CB 48)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+SAAS annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciAEXC573065:G1GPE-1862-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseSAAS annotation (EC:6.3.2.4SAAS annotation)
Gene namesi
Ordered Locus Names:Astex_1862Imported
OrganismiAsticcacaulis excentricus (strain ATCC 15261 / DSM 4724 / VKM B-1370 / CB 48)Imported
Taxonomic identifieri573065 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeAsticcacaulis
Proteomesi

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi573065.Astex_1862

Structurei

3D structure databases

ProteinModelPortaliE8RS00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 321ATP-graspInterPro annotationAdd BLAST194

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4105CPF Bacteria
COG1181 LUCA
HOGENOMiHOG000011592
KOiK01921
OMAiMQGLLEC
OrthoDBiPOG091H00GT

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00844 DALA_DALA_LIGASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

E8RS00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLTLLFGGL SRERLVAVAT TQSLHKALPE GDLWFWDEDN HVYEASSLAL
60 70 80 90 100
LGHQRPFEVP FRADGHDLGT IDQALDRAAA EDRVLVLGLH GGIAENGEFQ
110 120 130 140 150
VKCEARGVPF TGSGSAASHL AFDKVSAKRF AACAGVSSPA GIALSELDAA
160 170 180 190 200
FAEYGKLVAK PAQDGSSFGL IFVNSTNDLV AVRDAAKEQP YLIEPFVTGA
210 220 230 240 250
EATCAVLEQT DGSLIALPPI EIIPDRGAFD YHSKYLSNKT QEICPARFAP
260 270 280 290 300
EVIAEIQRLA IAAHKALSCR GYTRSDFIVS DKGPVFIETN TLPGMTASSL
310 320
YPKALAAQGI GFVEFLHGQV DIAIKRARA
Length:329
Mass (Da):35,198
Last modified:April 5, 2011 - v1
Checksum:iB7ABC1E8EF64F988
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002395 Genomic DNA Translation: ADU13525.1
RefSeqiWP_013479355.1, NC_014816.1

Genome annotation databases

EnsemblBacteriaiADU13525; ADU13525; Astex_1862
KEGGiaex:Astex_1862

Similar proteinsi

Entry informationi

Entry nameiE8RS00_ASTEC
AccessioniPrimary (citable) accession number: E8RS00
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 28, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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