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E8RS00

- E8RS00_ASTEC

UniProt

E8RS00 - E8RS00_ASTEC

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Protein
Submitted name:

D-alanine--D-alanine ligase

Gene

Astex_1862

Organism
Asticcacaulis excentricus (strain ATCC 15261 / DSM 4724 / VKM B-1370 / CB 48)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Note: Binds 2 magnesium or manganese ions per subunit.SAAS annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciAEXC573065:GJ7A-1886-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Submitted name:
D-alanine--D-alanine ligaseImported (EC:6.3.2.4Imported)
Gene namesi
Ordered Locus Names:Astex_1862Imported
OrganismiAsticcacaulis excentricus (strain ATCC 15261 / DSM 4724 / VKM B-1370 / CB 48)Imported
Taxonomic identifieri573065 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeAsticcacaulis
ProteomesiUP000001492: Chromosome 1

Subcellular locationi

Cytoplasm SAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliE8RS00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000011592.
KOiK01921.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8RS00-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLTLLFGGL SRERLVAVAT TQSLHKALPE GDLWFWDEDN HVYEASSLAL
60 70 80 90 100
LGHQRPFEVP FRADGHDLGT IDQALDRAAA EDRVLVLGLH GGIAENGEFQ
110 120 130 140 150
VKCEARGVPF TGSGSAASHL AFDKVSAKRF AACAGVSSPA GIALSELDAA
160 170 180 190 200
FAEYGKLVAK PAQDGSSFGL IFVNSTNDLV AVRDAAKEQP YLIEPFVTGA
210 220 230 240 250
EATCAVLEQT DGSLIALPPI EIIPDRGAFD YHSKYLSNKT QEICPARFAP
260 270 280 290 300
EVIAEIQRLA IAAHKALSCR GYTRSDFIVS DKGPVFIETN TLPGMTASSL
310 320
YPKALAAQGI GFVEFLHGQV DIAIKRARA
Length:329
Mass (Da):35,198
Last modified:April 5, 2011 - v1
Checksum:iB7ABC1E8EF64F988
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002395 Genomic DNA. Translation: ADU13525.1.
RefSeqiWP_013479355.1. NC_014816.1.
YP_004087676.1. NC_014816.1.

Genome annotation databases

EnsemblBacteriaiADU13525; ADU13525; Astex_1862.
GeneIDi10053435.
KEGGiaex:Astex_1862.
PATRICi45151686. VBIAstExc23432_1831.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002395 Genomic DNA. Translation: ADU13525.1 .
RefSeqi WP_013479355.1. NC_014816.1.
YP_004087676.1. NC_014816.1.

3D structure databases

ProteinModelPortali E8RS00.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADU13525 ; ADU13525 ; Astex_1862 .
GeneIDi 10053435.
KEGGi aex:Astex_1862.
PATRICi 45151686. VBIAstExc23432_1831.

Phylogenomic databases

HOGENOMi HOG000011592.
KOi K01921.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci AEXC573065:GJ7A-1886-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Asticcacaulis excentricus CB 48."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Teshima H., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N., Ovchinnikova G., Brun Y.V., Woyke T.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15261 / DSM 4724 / VKM B-1370 / CB 48Imported.

Entry informationi

Entry nameiE8RS00_ASTEC
AccessioniPrimary (citable) accession number: E8RS00
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 26, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3