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Protein

Elongation factor Tu

Gene

tuf

Organism
Filifactor alocis (strain ATCC 35896 / D40 B5) (Fusobacterium alocis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTPUniRule annotation
Nucleotide bindingi82 – 865GTPUniRule annotation
Nucleotide bindingi137 – 1404GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-HAMAP
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factorUniRule annotation

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciFALO546269:GHHW-1214-MONOMER.
FALO546269:GHHW-613-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor TuUniRule annotation
Short name:
EF-TuUniRule annotation
Gene namesi
Name:tufUniRule annotationImported
Ordered Locus Names:HMPREF0389_01692Imported, HMPREF0389_01733Imported
OrganismiFilifactor alocis (strain ATCC 35896 / D40 B5) (Fusobacterium alocis)Imported
Taxonomic identifieri546269 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeFilifactor
ProteomesiUP000007468: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

KOiK02358.
OMAiDEGGRHN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8RK92-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKAKFERSK PHVNIGTIGH VDHGKTTLTA AITRTLHEKY QLGEAVAFDN
60 70 80 90 100
IDKAPEERER GITISTSHVE YETPNRHYAH VDCPGHADYV KNMITGAAQM
110 120 130 140 150
DGAILVVSAA DGPMPQTREH ILLSRQVGVP YIVVFLNKCD MVDDEELLEL
160 170 180 190 200
VEMEVRDLLN EYEFPGDDTP IVRGSALKAL EDPNSKWGDA IVELFEQIDS
210 220 230 240 250
YIPEPERETD KPFLMPIEDI FSISGRGTVS TGRVERGVLH VSEEVEIVGL
260 270 280 290 300
ADEPRKVVVT GIEMFRKLLD EAQAGDNIGV LLRGVARDEI ERGQVLAKPG
310 320 330 340 350
TIHPHTKFTA NVYVLKKEEG GRHTPFFKGY RPQFYFRTTD VTGDITLPDG
360 370 380 390
VEMVMPGDNI TMTVELITKI AIEEGLRFAI REGGRTVGAG VVGKILE
Length:397
Mass (Da):43,984
Last modified:April 5, 2011 - v1
Checksum:i5AAD8B94F09E2712
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002390 Genomic DNA. Translation: ADW16138.1.
CP002390 Genomic DNA. Translation: ADW16177.1.
RefSeqiYP_005054361.1. NC_016630.1.
YP_005054902.1. NC_016630.1.

Genome annotation databases

EnsemblBacteriaiADW16138; ADW16138; HMPREF0389_01692.
ADW16177; ADW16177; HMPREF0389_01733.
GeneIDi11570112.
11570829.
KEGGifaa:HMPREF0389_01692.
faa:HMPREF0389_01733.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002390 Genomic DNA. Translation: ADW16138.1.
CP002390 Genomic DNA. Translation: ADW16177.1.
RefSeqiYP_005054361.1. NC_016630.1.
YP_005054902.1. NC_016630.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADW16138; ADW16138; HMPREF0389_01692.
ADW16177; ADW16177; HMPREF0389_01733.
GeneIDi11570112.
11570829.
KEGGifaa:HMPREF0389_01692.
faa:HMPREF0389_01733.

Phylogenomic databases

KOiK02358.
OMAiDEGGRHN.

Enzyme and pathway databases

BioCyciFALO546269:GHHW-1214-MONOMER.
FALO546269:GHHW-613-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC 35896Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35896 / D40 B5Imported.

Entry informationi

Entry nameiE8RK92_FILAD
AccessioniPrimary (citable) accession number: E8RK92
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: February 4, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.