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E8RC25

- E8RC25_DESPD

UniProt

E8RC25 - E8RC25_DESPD

Protein

Isocitrate dehydrogenase [NADP]

Gene

Despr_0574

Organism
Desulfobulbus propionicus (strain ATCC 33891 / DSM 2032 / 1pr3)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciDPRO577650:GH80-584-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:Despr_0574Imported
    OrganismiDesulfobulbus propionicus (strain ATCC 33891 / DSM 2032 / 1pr3)Imported
    Taxonomic identifieri577650 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfobulbus
    ProteomesiUP000006365: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliE8RC25.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiCLRPIRY.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E8RC25-1 [UniParc]FASTAAdd to Basket

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    MNRATASSQI NTPASNYKGE CATIDGRRAI EYSPHFVMRS MHRCSFVRIY    50
    GDLSSIKESI LTADIITLKA NGALNVPANP IIPYIEGDGT GPDIWAAAQK 100
    VLDAAVAKSY GQSRKIEWLE VLAGEKAFRV TGEWLPRETI DALKKYTVSI 150
    KGPLTTPVGE GMRSLNVTLR QVLDLYACVR PVRYYQGVVS PVKEPGLVDM 200
    VIFRENTEDV YAGIEWQAGT EKANRVIDFL RNEMGASIRD NSGIGIKPIS 250
    EFGTKRLVRK AIQYALDEGR NSVTLVHKGN IMKFTEGAFR HWGYELAAEE 300
    FGESTITETA LWEQFNGAIP EGKIVIKDRI ADAMFQQILL RPSEYSVLAM 350
    PNLNGDYISD ALAAQVGGLG MAPGANIGDG VALFEATHGT APKYAGLDKV 400
    NPGSVLLSGV MLLDYIGWKE AAELIKSALE TTISKKTVTY DLARLMEGAT 450
    ELSCSAFGSA IINNM 465
    Length:465
    Mass (Da):50,674
    Last modified:April 5, 2011 - v1
    Checksum:i65347506CD6252D0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002364 Genomic DNA. Translation: ADW16750.1.
    RefSeqiYP_004194041.1. NC_014972.1.

    Genome annotation databases

    EnsemblBacteriaiADW16750; ADW16750; Despr_0574.
    GeneIDi10173283.
    KEGGidpr:Despr_0574.
    PATRICi46934529. VBIDesPro114934_0605.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002364 Genomic DNA. Translation: ADW16750.1 .
    RefSeqi YP_004194041.1. NC_014972.1.

    3D structure databases

    ProteinModelPortali E8RC25.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADW16750 ; ADW16750 ; Despr_0574 .
    GeneIDi 10173283.
    KEGGi dpr:Despr_0574.
    PATRICi 46934529. VBIDesPro114934_0605.

    Phylogenomic databases

    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi CLRPIRY.

    Enzyme and pathway databases

    BioCyci DPRO577650:GH80-584-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33891 / DSM 2032 / 1pr3Imported.

    Entry informationi

    Entry nameiE8RC25_DESPD
    AccessioniPrimary (citable) accession number: E8RC25
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3