E8RC25 (E8RC25_DESPD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Isocitrate dehydrogenase [NADP] RuleBase RU004446
EC=1.1.1.42 RuleBase RU004446

Gene names

Ordered Locus Names:

Despr_0574

Organism

Desulfobulbus propionicus (strain ATCC 33891 / DSM 2032 / 1pr3) [Complete proteome] [HAMAP] EMBL ADW16750.1

Taxonomic identifier

577650 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfobacterales › Desulfobulbaceae › Desulfobulbus › Desulfobulbus propionicus

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. RuleBase RU004446
Cofactor	Binds 1 magnesium or manganese ion per subunit By similarity. RuleBase RU004446
Sequence similarities	Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443

Ontologies

Keywords
Biological process	Glyoxylate bypass RuleBase RU004446 Tricarboxylic acid cycle RuleBase RU004446
Ligand	Manganese RuleBase RU004446 Metal-binding RuleBase RU004446 NADP RuleBase RU004446
Molecular function	Oxidoreductase RuleBase RU004444 EMBL ADW16750.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glyoxylate cycle Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	NAD binding Inferred from electronic annotation. Source: InterPro isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E8RC25 [UniParc]. Last modified April 5, 2011. Version 1. Checksum: 65347506CD6252D0	FASTA	465	50,674
	10 20 30 40 50 60 MNRATASSQI NTPASNYKGE CATIDGRRAI EYSPHFVMRS MHRCSFVRIY GDLSSIKESI 70 80 90 100 110 120 LTADIITLKA NGALNVPANP IIPYIEGDGT GPDIWAAAQK VLDAAVAKSY GQSRKIEWLE 130 140 150 160 170 180 VLAGEKAFRV TGEWLPRETI DALKKYTVSI KGPLTTPVGE GMRSLNVTLR QVLDLYACVR 190 200 210 220 230 240 PVRYYQGVVS PVKEPGLVDM VIFRENTEDV YAGIEWQAGT EKANRVIDFL RNEMGASIRD 250 260 270 280 290 300 NSGIGIKPIS EFGTKRLVRK AIQYALDEGR NSVTLVHKGN IMKFTEGAFR HWGYELAAEE 310 320 330 340 350 360 FGESTITETA LWEQFNGAIP EGKIVIKDRI ADAMFQQILL RPSEYSVLAM PNLNGDYISD 370 380 390 400 410 420 ALAAQVGGLG MAPGANIGDG VALFEATHGT APKYAGLDKV NPGSVLLSGV MLLDYIGWKE 430 440 450 460 AAELIKSALE TTISKKTVTY DLARLMEGAT ELSCSAFGSA IINNM

References

[1]

"Complete genome sequence of Desulfobulbus propionicus type strain (1pr3)." Pagani I., Lapidus A., Nolan M., Lucas S., Hammon N., Deshpande S., Cheng J.F., Chertkov O., Davenport K., Tapia R., Han C., Goodwin L., Pitluck S., Liolios K., Mavromatis K., Ivanova N., Mikhailova N., Pati A. , Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D., Detter J.C., Brambilla E., Kannan K.P., Djao O.D., Rohde M., Pukall R., Spring S., Goker M., Sikorski J., Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P. Stand. Genomic Sci. 4:100-110(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33891 / DSM 2032 / 1pr3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002364 Genomic DNA. Translation: ADW16750.1.
RefSeq	YP_004194041.1. NC_014972.1.
3D structure databases
ProteinModelPortal	E8RC25.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADW16750; ADW16750; Despr_0574.
GeneID	10173283.
KEGG	dpr:Despr_0574.
PATRIC	46934529. VBIDesPro114934_0605.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000021113.
KO	K00031.
OMA	RIRWHEL.
Enzyme and pathway databases
BioCyc	DPRO577650:GH80-584-MONOMER.
Family and domain databases
Gene3D	3.40.718.10. 1 hit.
InterPro	IPR019818. IsoCit/isopropylmalate_DH_CS. IPR001804. Isocitrate/isopropylmalate_DH. IPR004439. Isocitrate_DH_NADP_dimer_prok. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
PANTHER	PTHR11835. PTHR11835. 1 hit.
Pfam	PF00180. Iso_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR00183. prok_nadp_idh. 1 hit.
PROSITE	PS00470. IDH_IMDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

E8RC25_DESPD

Accession

Primary (citable) accession number: E8RC25

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	April 3, 2013
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)