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Protein

Isocitrate dehydrogenase [NADP]

Gene

Despr_0574

Organism
Desulfobulbus propionicus (strain ATCC 33891 / DSM 2032 / 1pr3)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciDPRO577650:GH80-584-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Despr_0574Imported
OrganismiDesulfobulbus propionicus (strain ATCC 33891 / DSM 2032 / 1pr3)Imported
Taxonomic identifieri577650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfobulbus
ProteomesiUP000006365 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE8RC25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.
OMAiFRDWGYE.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8RC25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRATASSQI NTPASNYKGE CATIDGRRAI EYSPHFVMRS MHRCSFVRIY
60 70 80 90 100
GDLSSIKESI LTADIITLKA NGALNVPANP IIPYIEGDGT GPDIWAAAQK
110 120 130 140 150
VLDAAVAKSY GQSRKIEWLE VLAGEKAFRV TGEWLPRETI DALKKYTVSI
160 170 180 190 200
KGPLTTPVGE GMRSLNVTLR QVLDLYACVR PVRYYQGVVS PVKEPGLVDM
210 220 230 240 250
VIFRENTEDV YAGIEWQAGT EKANRVIDFL RNEMGASIRD NSGIGIKPIS
260 270 280 290 300
EFGTKRLVRK AIQYALDEGR NSVTLVHKGN IMKFTEGAFR HWGYELAAEE
310 320 330 340 350
FGESTITETA LWEQFNGAIP EGKIVIKDRI ADAMFQQILL RPSEYSVLAM
360 370 380 390 400
PNLNGDYISD ALAAQVGGLG MAPGANIGDG VALFEATHGT APKYAGLDKV
410 420 430 440 450
NPGSVLLSGV MLLDYIGWKE AAELIKSALE TTISKKTVTY DLARLMEGAT
460
ELSCSAFGSA IINNM
Length:465
Mass (Da):50,674
Last modified:April 5, 2011 - v1
Checksum:i65347506CD6252D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002364 Genomic DNA. Translation: ADW16750.1.
RefSeqiWP_015723295.1. NC_014972.1.
YP_004194041.1. NC_014972.1.

Genome annotation databases

EnsemblBacteriaiADW16750; ADW16750; Despr_0574.
KEGGidpr:Despr_0574.
PATRICi46934529. VBIDesPro114934_0605.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002364 Genomic DNA. Translation: ADW16750.1.
RefSeqiWP_015723295.1. NC_014972.1.
YP_004194041.1. NC_014972.1.

3D structure databases

ProteinModelPortaliE8RC25.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADW16750; ADW16750; Despr_0574.
KEGGidpr:Despr_0574.
PATRICi46934529. VBIDesPro114934_0605.

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.
OMAiFRDWGYE.

Enzyme and pathway databases

BioCyciDPRO577650:GH80-584-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33891 / DSM 2032 / 1pr3Imported.

Entry informationi

Entry nameiE8RC25_DESPD
AccessioniPrimary (citable) accession number: E8RC25
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: May 27, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.