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E8RAK5

- E8RAK5_DESM0

UniProt

E8RAK5 - E8RAK5_DESM0

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Protein

Ribulose bisphosphate carboxylase

Gene

rbcL

Organism
Desulfurococcus mucosus (strain ATCC 35584 / DSM 2162 / JCM 9187 / O7/1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei164 – 1641Proton acceptorUniRule annotation
Binding sitei166 – 1661SubstrateUniRule annotation
Metal bindingi190 – 1901Magnesium; via carbamate groupUniRule annotation
Metal bindingi192 – 1921MagnesiumUniRule annotation
Metal bindingi193 – 1931MagnesiumUniRule annotation
Active sitei282 – 2821Proton acceptorUniRule annotation
Binding sitei283 – 2831SubstrateUniRule annotation
Binding sitei315 – 3151SubstrateUniRule annotation
Sitei323 – 3231Transition state stabilizerUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. oxidoreductase activity Source: UniProtKB-KW
  3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. AMP catabolic process Source: UniProtKB-HAMAP
  2. carbon fixation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciDMUC765177:GHQE-1178-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotation
Ordered Locus Names:Desmu_1141Imported
OrganismiDesulfurococcus mucosus (strain ATCC 35584 / DSM 2162 / JCM 9187 / O7/1)Imported
Taxonomic identifieri765177 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeDesulfurococcus
ProteomesiUP000001068: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei190 – 1901N6-carboxylysineUniRule annotation

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE8RAK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni368 – 3703Substrate bindingUniRule annotation
Regioni390 – 3934Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the RuBisCO large chain family. Type III subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230831.
KOiK01601.
OMAiFTQDWAS.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01133. RuBisCO_L_type3.
InterProiIPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.

Sequencei

Sequence statusi: Complete.

E8RAK5 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSKFDFETY HEYVNRDYNP DPDNDVVAVF RVKPAPGFTI EDAAGGVAAE
60 70 80 90 100
SSTGTWTSLY SWYDVTRVRR LSGKAYFFRD LGDGSWIVRI AYPVELFEEG
110 120 130 140 150
NIPGLLASIA GNIFGMKRVE ALRLEDIYLP RKFLESFKGP SKGVAGVKEI
160 170 180 190 200
FKVSDRPIVG TVPKPKEGYS PDEVEKLAFE LLSGGLDYVK DDENLTSPSF
210 220 230 240 250
CRFEARAKAI MRVIDKVEKE TGERKAWFAN ITSDIREMEK RLRLVADYGN
260 270 280 290 300
PYVMVDVVIT GWSALTYIRD IAEEYGLAIH GHRAMHAAFT RNPYHGISMY
310 320 330 340 350
VLAKLYRIIG IDQLHIGTAG AGKLEGGKID VIRYARILRE NHFKPDQDDQ
360 370 380 390 400
FHLEQPMHHI KPAMPVSSGG LHPGNIQPVI EALGSNIVLQ IGGGVIGHPD
410 420 430 440
GPRAGALAVR QALEAISKGI PLDEYMKTHR ELARAIEKWG FVKPI
Length:445
Mass (Da):49,623
Last modified:April 5, 2011 - v1
Checksum:iB2BC578CEDE48E49
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002363 Genomic DNA. Translation: ADV65441.1.
RefSeqiWP_013562663.1. NC_014961.1.
YP_004176923.1. NC_014961.1.

Genome annotation databases

EnsemblBacteriaiADV65441; ADV65441; Desmu_1141.
GeneIDi10153855.
KEGGidmu:Desmu_1141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002363 Genomic DNA. Translation: ADV65441.1 .
RefSeqi WP_013562663.1. NC_014961.1.
YP_004176923.1. NC_014961.1.

3D structure databases

ProteinModelPortali E8RAK5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADV65441 ; ADV65441 ; Desmu_1141 .
GeneIDi 10153855.
KEGGi dmu:Desmu_1141.

Phylogenomic databases

HOGENOMi HOG000230831.
KOi K01601.
OMAi FTQDWAS.

Enzyme and pathway databases

BioCyci DMUC765177:GHQE-1178-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPi MF_01133. RuBisCO_L_type3.
InterProi IPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35584 / DSM 2162 / JCM 9187 / O7/1Imported.

Entry informationi

Entry nameiE8RAK5_DESM0
AccessioniPrimary (citable) accession number: E8RAK5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 29, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.UniRule annotation

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3