ID   E8RA46_DESM0            Unreviewed;       454 AA.
AC   E8RA46;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   SubName: Full=4-aminobutyrate aminotransferase apoenzyme {ECO:0000313|EMBL:ADV64324.1};
DE            EC=2.6.1.19 {ECO:0000313|EMBL:ADV64324.1};
GN   OrderedLocusNames=Desmu_0005 {ECO:0000313|EMBL:ADV64324.1};
OS   Desulfurococcus mucosus (strain ATCC 35584 / DSM 2162 / JCM 9187 / O7/1).
OC   Archaea; Thermoproteota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Desulfurococcus.
OX   NCBI_TaxID=765177 {ECO:0000313|EMBL:ADV64324.1, ECO:0000313|Proteomes:UP000001068};
RN   [1] {ECO:0000313|Proteomes:UP000001068}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35584 / DSM 2162 / JCM 9187 / O7/1
RC   {ECO:0000313|Proteomes:UP000001068};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA   Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Ovchinnikova G.,
RA   Chertkov O., Held B., Brettin T., Detter J.C., Tapia R., Han C., Land M.,
RA   Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA   Wirth R., Bilek Y., Hader T., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Desulfurococcus mucosus DSM 2162.";
RL   Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADV64324.1, ECO:0000313|Proteomes:UP000001068}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35584 / DSM 2162 / JCM 9187 / O7/1
RC   {ECO:0000313|Proteomes:UP000001068};
RX   PubMed=21677854; DOI=10.4056/sigs.1644004;
RA   Wirth R., Chertkov O., Held B., Lapidus A., Nolan M., Lucas S., Hammon N.,
RA   Deshpande S., Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S.,
RA   Liolios K., Ioanna P., Ivanova N., Mavromatis K., Mikhailova N., Pati A.,
RA   Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA   Bilek Y., Hader T., Rohde M., Spring S., Sikorski J., Goker M., Woyke T.,
RA   Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA   Klenk H.P.;
RT   "Complete genome sequence of Desulfurococcus mucosus type strain (O7/1).";
RL   Stand. Genomic Sci. 4:173-182(2011).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- SIMILARITY: Belongs to the class-III pyridoxal-phosphate-dependent
CC       aminotransferase family. {ECO:0000256|RuleBase:RU003560}.
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DR   EMBL; CP002363; ADV64324.1; -; Genomic_DNA.
DR   RefSeq; WP_013561546.1; NC_014961.1.
DR   AlphaFoldDB; E8RA46; -.
DR   STRING; 765177.Desmu_0005; -.
DR   GeneID; 10152684; -.
DR   KEGG; dmu:Desmu_0005; -.
DR   eggNOG; arCOG00915; Archaea.
DR   HOGENOM; CLU_016922_10_0_2; -.
DR   OrthoDB; 6534at2157; -.
DR   Proteomes; UP000001068; Chromosome.
DR   GO; GO:0034386; F:4-aminobutyrate:2-oxoglutarate transaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   CDD; cd00610; OAT_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR005814; Aminotrans_3.
DR   InterPro; IPR049704; Aminotrans_3_PPA_site.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR11986; AMINOTRANSFERASE CLASS III; 1.
DR   PANTHER; PTHR11986:SF58; LEUCINE_METHIONINE RACEMASE; 1.
DR   Pfam; PF00202; Aminotran_3; 1.
DR   PIRSF; PIRSF000521; Transaminase_4ab_Lys_Orn; 2.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00600; AA_TRANSFER_CLASS_3; 1.
PE   3: Inferred from homology;
KW   Aminotransferase {ECO:0000313|EMBL:ADV64324.1};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|RuleBase:RU003560};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001068};
KW   Transferase {ECO:0000313|EMBL:ADV64324.1}.
SQ   SEQUENCE   454 AA;  49975 MW;  4CE4B29D7DF25635 CRC64;
     MGSPSRARGT SSQLIEKYKR YVSGSQAFKY FPMIVGKALN ARIWDTDGRE YIDFLSSAAT
     YNVGHSNREV LEAVKTQLDK FIHYCLYLYH EPVVELAELL AGITPGSFEK KVAFGLSGGD
     ANDAALKAAL VYTRRRVIVS FDYSYHGTTA LDIAVSGSFS PELRGLMPFR DVYFAEYPDT
     YRCIGGVEDP EECGELYLSR FEELLKKIGG SNVAAIILEP VQGDGGVLIP PANFIKGVRK
     MASEHGIVLI DDEVQTGMGR TGRLFAIEHY SVEPDLMVLG KALGGGMPVS AVVGRSDIMD
     SAPPQSFFAT SAAHAASVAA AIAVVKYVTR NNLHERAREM GEYALKRLNE LKEKYEVVGD
     VRGLGLMIGV DIVVDKKSKR PDRAKALKII WRAWEKGLVM MTYGKYGNVL RIAPPLTIPR
     EDLDKGIDII EESVKDVLEG KVPDEVVDKM TAWK
//