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Protein

Glyceraldehyde-3-phosphate dehydrogenase

Gene

gap

Organism
Desulfurococcus mucosus (strain ATCC 35584 / DSM 2162 / JCM 9187 / O7/1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H.UniRule annotationSAAS annotation

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (gap)
  2. Phosphoglycerate kinase (pgk)
  3. no protein annotated in this organism
  4. Enolase (eno)
  5. Pyruvate kinase (Desmu_1237)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei110NAD; via amide nitrogenUniRule annotation1
Active sitei140NucleophileUniRule annotation1
Binding sitei168NADUniRule annotation1
Binding sitei302NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 13NADUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported
Biological processGlycolysisUniRule annotationSAAS annotation
LigandNADUniRule annotationSAAS annotation, NADPUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciDMUC765177:G1GR1-856-MONOMER
UniPathwayiUPA00109; UER00184

Names & Taxonomyi

Protein namesi
Recommended name:
Glyceraldehyde-3-phosphate dehydrogenaseUniRule annotation (EC:1.2.1.59UniRule annotation)
Short name:
GAPDHUniRule annotation
Alternative name(s):
NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenaseUniRule annotation
Gene namesi
Name:gapUniRule annotation
Ordered Locus Names:Desmu_0845Imported
OrganismiDesulfurococcus mucosus (strain ATCC 35584 / DSM 2162 / JCM 9187 / O7/1)Imported
Taxonomic identifieri765177 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeDesulfurococcus
Proteomesi
  • UP000001068 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi765177.Desmu_0845

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 140Gp_dh_NInterPro annotationAdd BLAST138

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni139 – 141Glyceraldehyde 3-phosphate bindingUniRule annotation3
Regioni194 – 195Glyceraldehyde 3-phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiarCOG00493 Archaea
COG0057 LUCA
HOGENOMiHOG000223361
KOiK00150
OMAiNAIVPNP
OrthoDBiPOG093Z05Z6

Family and domain databases

HAMAPiMF_00559 G3P_dehdrog_arch, 1 hit
InterProiView protein in InterPro
IPR020831 GlycerAld/Erythrose_P_DH
IPR020830 GlycerAld_3-P_DH_AS
IPR020829 GlycerAld_3-P_DH_cat
IPR020828 GlycerAld_3-P_DH_NAD(P)-bd
IPR006436 Glyceraldehyde-3-P_DH_2_arc
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR10836 PTHR10836, 1 hit
PTHR10836:SF76 PTHR10836:SF76, 1 hit
PfamiView protein in Pfam
PF02800 Gp_dh_C, 1 hit
PF00044 Gp_dh_N, 1 hit
PIRSFiPIRSF000149 GAP_DH, 1 hit
SMARTiView protein in SMART
SM00846 Gp_dh_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01546 GAPDH-II_archae, 1 hit
PROSITEiView protein in PROSITE
PS00071 GAPDH, 1 hit

Sequencei

Sequence statusi: Complete.

E8R9H3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVKIAVNGY GTIGKRIVDA VLSNKDFRLV GIAKYRVDYS AYLAARKGIP
60 70 80 90 100
IYVPRERASE FREAGLEPHG YVDYLFEEAD LIYDASPGGK GAGNKKIYES
110 120 130 140 150
YGKPGVFQGG EEPGVAELSY STLCNFEEAL NKKYVRVVSC NTTGMLRLLC
160 170 180 190 200
TLHREYGVKR ALSVIIRRAA DPKEDQRGPV NSILLDPPSI PSHHGLDART
210 220 230 240 250
VAPWLDIVTA AAVVPTTLMH MQFIEVELST QVNRGDVVEL LDGINRFLLV
260 270 280 290 300
ESASTGIDST SKVMELARDS GRPRGDIYEN IVFIDSLSIN ASRLYLFQGI
310 320 330 340 350
HQESIVIPEN IDVAYAMLGI ESDPLKVMER VDSTLGIGGL RRFISPHGYI

QIGGAP
Length:356
Mass (Da):39,090
Last modified:April 5, 2011 - v1
Checksum:i6384484C0E4929EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002363 Genomic DNA Translation: ADV65149.1
RefSeqiWP_013562371.1, NC_014961.1

Genome annotation databases

EnsemblBacteriaiADV65149; ADV65149; Desmu_0845
GeneIDi10153542
KEGGidmu:Desmu_0845

Similar proteinsi

Entry informationi

Entry nameiE8R9H3_DESM0
AccessioniPrimary (citable) accession number: E8R9H3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 28, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health