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E8R9H3

- E8R9H3_DESM0

UniProt

E8R9H3 - E8R9H3_DESM0

Protein

Glyceraldehyde-3-phosphate dehydrogenase

Gene

gap

Organism
Desulfurococcus mucosus (strain ATCC 35584 / DSM 2162 / JCM 9187 / O7/1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei110 – 1101NAD; via amide nitrogenUniRule annotation
    Active sitei140 – 1401NucleophileUniRule annotation
    Binding sitei168 – 1681NADUniRule annotation
    Binding sitei302 – 3021NAD; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 132NADUniRule annotation

    GO - Molecular functioni

    1. glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity Source: UniProtKB-EC
    2. glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity Source: UniProtKB-HAMAP
    3. NAD binding Source: InterPro
    4. NADP binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    GlycolysisUniRule annotationSAAS annotation

    Keywords - Ligandi

    NADUniRule annotationSAAS annotation, NADPUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciDMUC765177:GHQE-865-MONOMER.
    UniPathwayiUPA00109; UER00184.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glyceraldehyde-3-phosphate dehydrogenaseUniRule annotation (EC:1.2.1.59UniRule annotation)
    Short name:
    GAPDHUniRule annotation
    Alternative name(s):
    NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenaseUniRule annotation
    Gene namesi
    Name:gapUniRule annotation
    Ordered Locus Names:Desmu_0845Imported
    OrganismiDesulfurococcus mucosus (strain ATCC 35584 / DSM 2162 / JCM 9187 / O7/1)Imported
    Taxonomic identifieri765177 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeDesulfurococcus
    ProteomesiUP000001068: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni139 – 1413Glyceraldehyde 3-phosphate bindingUniRule annotation
    Regioni194 – 1952Glyceraldehyde 3-phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000223361.
    KOiK00150.
    OMAiVTVPSHH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00559. G3P_dehdrog_arch.
    InterProiIPR020831. GlycerAld/Erythrose_P_DH.
    IPR020830. GlycerAld_3-P_DH_AS.
    IPR020829. GlycerAld_3-P_DH_cat.
    IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
    IPR006436. Glyceraldehyde-3-P_DH_2_arc.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF02800. Gp_dh_C. 1 hit.
    PF00044. Gp_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000149. GAP_DH. 1 hit.
    SMARTiSM00846. Gp_dh_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01546. GAPDH-II_archae. 1 hit.
    PROSITEiPS00071. GAPDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E8R9H3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVKIAVNGY GTIGKRIVDA VLSNKDFRLV GIAKYRVDYS AYLAARKGIP    50
    IYVPRERASE FREAGLEPHG YVDYLFEEAD LIYDASPGGK GAGNKKIYES 100
    YGKPGVFQGG EEPGVAELSY STLCNFEEAL NKKYVRVVSC NTTGMLRLLC 150
    TLHREYGVKR ALSVIIRRAA DPKEDQRGPV NSILLDPPSI PSHHGLDART 200
    VAPWLDIVTA AAVVPTTLMH MQFIEVELST QVNRGDVVEL LDGINRFLLV 250
    ESASTGIDST SKVMELARDS GRPRGDIYEN IVFIDSLSIN ASRLYLFQGI 300
    HQESIVIPEN IDVAYAMLGI ESDPLKVMER VDSTLGIGGL RRFISPHGYI 350
    QIGGAP 356
    Length:356
    Mass (Da):39,090
    Last modified:April 5, 2011 - v1
    Checksum:i6384484C0E4929EA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002363 Genomic DNA. Translation: ADV65149.1.
    RefSeqiYP_004176631.1. NC_014961.1.

    Genome annotation databases

    EnsemblBacteriaiADV65149; ADV65149; Desmu_0845.
    GeneIDi10153542.
    KEGGidmu:Desmu_0845.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002363 Genomic DNA. Translation: ADV65149.1 .
    RefSeqi YP_004176631.1. NC_014961.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADV65149 ; ADV65149 ; Desmu_0845 .
    GeneIDi 10153542.
    KEGGi dmu:Desmu_0845.

    Phylogenomic databases

    HOGENOMi HOG000223361.
    KOi K00150.
    OMAi VTVPSHH.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00184 .
    BioCyci DMUC765177:GHQE-865-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00559. G3P_dehdrog_arch.
    InterProi IPR020831. GlycerAld/Erythrose_P_DH.
    IPR020830. GlycerAld_3-P_DH_AS.
    IPR020829. GlycerAld_3-P_DH_cat.
    IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
    IPR006436. Glyceraldehyde-3-P_DH_2_arc.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF02800. Gp_dh_C. 1 hit.
    PF00044. Gp_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000149. GAP_DH. 1 hit.
    SMARTi SM00846. Gp_dh_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01546. GAPDH-II_archae. 1 hit.
    PROSITEi PS00071. GAPDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35584 / DSM 2162 / JCM 9187 / O7/1Imported.

    Entry informationi

    Entry nameiE8R9H3_DESM0
    AccessioniPrimary (citable) accession number: E8R9H3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3