ID   E8R8M5_DESM0            Unreviewed;       442 AA.
AC   E8R8M5;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   SubName: Full=4-aminobutyrate aminotransferase apoenzyme {ECO:0000313|EMBL:ADV64851.1};
DE            EC=2.6.1.19 {ECO:0000313|EMBL:ADV64851.1};
GN   OrderedLocusNames=Desmu_0541 {ECO:0000313|EMBL:ADV64851.1};
OS   Desulfurococcus mucosus (strain ATCC 35584 / DSM 2162 / JCM 9187 / O7/1).
OC   Archaea; Thermoproteota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Desulfurococcus.
OX   NCBI_TaxID=765177 {ECO:0000313|EMBL:ADV64851.1, ECO:0000313|Proteomes:UP000001068};
RN   [1] {ECO:0000313|Proteomes:UP000001068}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35584 / DSM 2162 / JCM 9187 / O7/1
RC   {ECO:0000313|Proteomes:UP000001068};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA   Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Ovchinnikova G.,
RA   Chertkov O., Held B., Brettin T., Detter J.C., Tapia R., Han C., Land M.,
RA   Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA   Wirth R., Bilek Y., Hader T., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Desulfurococcus mucosus DSM 2162.";
RL   Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADV64851.1, ECO:0000313|Proteomes:UP000001068}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35584 / DSM 2162 / JCM 9187 / O7/1
RC   {ECO:0000313|Proteomes:UP000001068};
RX   PubMed=21677854; DOI=10.4056/sigs.1644004;
RA   Wirth R., Chertkov O., Held B., Lapidus A., Nolan M., Lucas S., Hammon N.,
RA   Deshpande S., Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S.,
RA   Liolios K., Ioanna P., Ivanova N., Mavromatis K., Mikhailova N., Pati A.,
RA   Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA   Bilek Y., Hader T., Rohde M., Spring S., Sikorski J., Goker M., Woyke T.,
RA   Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA   Klenk H.P.;
RT   "Complete genome sequence of Desulfurococcus mucosus type strain (O7/1).";
RL   Stand. Genomic Sci. 4:173-182(2011).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- SIMILARITY: Belongs to the class-III pyridoxal-phosphate-dependent
CC       aminotransferase family. {ECO:0000256|RuleBase:RU003560}.
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DR   EMBL; CP002363; ADV64851.1; -; Genomic_DNA.
DR   RefSeq; WP_013562073.1; NC_014961.1.
DR   AlphaFoldDB; E8R8M5; -.
DR   STRING; 765177.Desmu_0541; -.
DR   GeneID; 10153234; -.
DR   KEGG; dmu:Desmu_0541; -.
DR   eggNOG; arCOG00915; Archaea.
DR   HOGENOM; CLU_016922_10_0_2; -.
DR   OrthoDB; 6534at2157; -.
DR   Proteomes; UP000001068; Chromosome.
DR   GO; GO:0034386; F:4-aminobutyrate:2-oxoglutarate transaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   CDD; cd00610; OAT_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR005814; Aminotrans_3.
DR   InterPro; IPR049704; Aminotrans_3_PPA_site.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR11986; AMINOTRANSFERASE CLASS III; 1.
DR   PANTHER; PTHR11986:SF58; LEUCINE_METHIONINE RACEMASE; 1.
DR   Pfam; PF00202; Aminotran_3; 1.
DR   PIRSF; PIRSF000521; Transaminase_4ab_Lys_Orn; 2.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00600; AA_TRANSFER_CLASS_3; 1.
PE   3: Inferred from homology;
KW   Aminotransferase {ECO:0000313|EMBL:ADV64851.1};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|RuleBase:RU003560};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001068};
KW   Transferase {ECO:0000313|EMBL:ADV64851.1}.
SQ   SEQUENCE   442 AA;  48193 MW;  60F551741515E212 CRC64;
     MVLDPGPIPR PFTLKYFPFK AVEGRGARVL DAEGREFIDF VSGAAVYNVG INREEVVNAV
     VDQARRLLNY TSLYFYMEEP VRLARKLVEV TPGRFDKRVV YGFTGSDAAE IALTSSMNYT
     GKPWLLSFTG SFHGTLYLSL SASGIFAGRG RGAAVYRRVL YAEYPNPYRN KWGVDGYEKP
     GELTALALSE VEEKIREAKG DVAAVIFEPV EGDAGVVVPP AGFLKGLREV ADRHGVVLIG
     DEVQTGIGRT GSMWAVEHFS VEPDLLLAGK ALGGGMPISA VIGRAEILES QPLLGLGFTN
     MGHAVCARAA LATIEVVEKE HLAERARVLG EHASKRLREI AERVEAVGDV RGLGLMIGVE
     VVRDKASRRP DRATALKTCW RAWEKGLLVT TLGSHGNVLR IMPPLTISME ELDKGIDVLE
     ESLRDAVEGR VPDEVLGFMQ GW
//