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E8QSD0

- E8QSD0_HELPW

UniProt

E8QSD0 - E8QSD0_HELPW

Protein

Alanine racemase

Gene

HPSA_04550

Organism
Helicobacter pylori (strain SouthAfrica7)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei37 – 371Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei135 – 1351SubstrateUniRule annotation
    Active sitei271 – 2711Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei319 – 3191Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciHPYL907239:GLES-880-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:HPSA_04550Imported
    OrganismiHelicobacter pylori (strain SouthAfrica7)Imported
    Taxonomic identifieri907239 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000007467: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei37 – 371N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE8QSD0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E8QSD0-1 [UniParc]FASTAAdd to Basket

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    MLKRASFVEV DTSSLRHNFN AVKNAIPKDT HIMAVVKANA YGVGAIKASE    50
    IFLQEGAHYL GVATLDEALE LRFHFPKTPI LILGYSPNSN AQMLVDNHLS 100
    AMIFSLEQAE IFSQIALKSK KRLKVHLKID TGMHRLGLEP NFKSVEIIKK 150
    IRALKGLEVE GIFTHLSNAD ANIKTHAKNQ MKAFNAFLEQ LLDQKIEFQY 200
    RHAYNSAGIL SLCNNNENRF LNLYRPGIML YGFYPSNEMK ESCPTILKNV 250
    VSLKAQIVQI KRVKKGEFVG YGKHFYTNEE TLVGVLALGY ADGLARALGN 300
    RIQVVINNQL APLIAKVCMD QCFIKLDGIE AKEGDEVILF GDKSTRANDA 350
    NEIATLLNTI PYEVISTLSK RLERVYA 377
    Length:377
    Mass (Da):42,188
    Last modified:April 5, 2011 - v1
    Checksum:iB776639A6A360232
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002336 Genomic DNA. Translation: ADU84894.1.
    RefSeqiYP_005771501.1. NC_017361.1.

    Genome annotation databases

    EnsemblBacteriaiADU84894; ADU84894; HPSA_04550.
    GeneIDi12349816.
    KEGGihes:HPSA_04550.
    PATRICi45400165. VBIHelPyl171460_0925.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002336 Genomic DNA. Translation: ADU84894.1 .
    RefSeqi YP_005771501.1. NC_017361.1.

    3D structure databases

    ProteinModelPortali E8QSD0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADU84894 ; ADU84894 ; HPSA_04550 .
    GeneIDi 12349816.
    KEGGi hes:HPSA_04550.
    PATRICi 45400165. VBIHelPyl171460_0925.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci HPYL907239:GLES-880-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Helicobacter pylori strain SouthAfrica7."
      Kersulyte D., Segal I., Mistry R., Berg D.E.
      Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SouthAfrica7Imported.

    Entry informationi

    Entry nameiE8QSD0_HELPW
    AccessioniPrimary (citable) accession number: E8QSD0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3