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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Streptococcus dysgalactiae subsp. equisimilis (strain ATCC 12394 / D166B)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381UniRule annotation
Active sitei584 – 5841UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciSDYS663954:GLL0-684-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:SDE12394_03325Imported
OrganismiStreptococcus dysgalactiae subsp. equisimilis (strain ATCC 12394 / D166B)Imported
Taxonomic identifieri663954 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000008977: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

KOiK01595.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8Q8P2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKKLESSN NQAIIAEEVA ILKDMLEKIT RRMIGDEAFA TIETIVALSE
60 70 80 90 100
KQDYVGLETI IASISNQDMD VISRYFSILP LLINISEDVD LAYEINYQNN
110 120 130 140 150
ANKDYLGKLA LTIDAVAEKE NAKDILEQVN VVPVLTAHPT QVQRKTILEL
160 170 180 190 200
TTHIHDLLRK YRDVKAGVVN QEKWHNELYR YIEIIMQTDI IREKKLKVKN
210 220 230 240 250
EITNVMQYYN GSLIQAVTKL TTEYKNLAQK RGLDLINPNP ITMGMWIGGD
260 270 280 290 300
RDGNPFVTAE TLRLSATVQS EVILNYYIEK LAALYRTFSL SSTLIQPSAE
310 320 330 340 350
VERLASLSQD QSIYRENEPY RRAFHYVKSR LVQTRTQLTG DQDTTGQSLT
360 370 380 390 400
ADRLTRQLAM QDQLEGPIAA YVSPEDFKAD LMAIEQSLLS NGDVALVDGD
410 420 430 440 450
LREVMQAVDI FGFFLASIDM RQDSSVQEAC VAELLKGANI VEDYSSLSET
460 470 480 490 500
EKCDLLVKQL TEDPRTLSSA AVAKSDLLEK ELAIYAAARE LKDKLGDEVI
510 520 530 540 550
KQHIISHTES VSDMFELAIM LKEVGLIDQH KARVQIVPLF ETIEDLDNAR
560 570 580 590 600
DIMTTYLSYD MVKSWIAANH NYQEIMLGYS DSNKDGGYLA SGWTLYKAQN
610 620 630 640 650
ELTAIGEENG VKITFFHGRG GTVGRGGGPS YDAITSQPFG SIKDRIRLTE
660 670 680 690 700
QGEIIENKYG NKDVAYYHLE MLISASINRM VTQMLTNPNE IDGFREVMDG
710 720 730 740 750
IVADSNKIYR QLVFDNPHFY DYFFEASPIK EVSSLNIGSR PAARKTITEI
760 770 780 790 800
TGLRAIPWVF SWSQNRIMFP GWYGVGSAFK HYIDQAEGNL ERLQHMYQTW
810 820 830 840 850
PFFHSLLSNV DMVLSKSNMN IAFQYAQLAD SQEVRDVFHV ILDEWQLTKN
860 870 880 890 900
VILAIEGHEE LLEDNPSLKQ SLAFRLPYFN VLNYIQIELI KRLRNHQLRE
910 920
EDEKLIHTTI NGIATGLRNS G
Length:921
Mass (Da):104,481
Last modified:April 5, 2011 - v1
Checksum:i516296D5EC5E15E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002215 Genomic DNA. Translation: ADX24188.1.
RefSeqiYP_006012768.1. NC_017567.1.

Genome annotation databases

EnsemblBacteriaiADX24188; ADX24188; SDE12394_03325.
GeneIDi12608323.
KEGGisdg:SDE12394_03325.
PATRICi47208247. VBIStrDys144480_0656.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002215 Genomic DNA. Translation: ADX24188.1.
RefSeqiYP_006012768.1. NC_017567.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADX24188; ADX24188; SDE12394_03325.
GeneIDi12608323.
KEGGisdg:SDE12394_03325.
PATRICi47208247. VBIStrDys144480_0656.

Phylogenomic databases

KOiK01595.

Enzyme and pathway databases

BioCyciSDYS663954:GLL0-684-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomic analysis of the Streptococcus dysgalactiae species group: gene content, molecular adaptation, and promoter evolution."
    Suzuki H., Lefebure T., Hubisz M.J., Pavinski Bitar P., Lang P., Siepel A., Stanhope M.J.
    Genome Biol. Evol. 3:168-185(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12394 / D166BImported.

Entry informationi

Entry nameiE8Q8P2_STRED
AccessioniPrimary (citable) accession number: E8Q8P2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 4, 2015
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.