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E8PI12

- E8PI12_ACIB1

UniProt

E8PI12 - E8PI12_ACIB1

Protein

Alanine racemase

Gene

ABK1_1312

Organism
Acinetobacter baumannii (strain 1656-2)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei34 – 341Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Active sitei254 – 2541Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei302 – 3021Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciABAU696749:GL7T-1356-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:ABK1_1312Imported
    OrganismiAcinetobacter baumannii (strain 1656-2)Imported
    Taxonomic identifieri696749 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
    ProteomesiUP000008976: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei34 – 341N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE8PI12.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.
    OMAiAEININN.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E8PI12-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRQATVYIDR QALQYNLNRV KQLAANSKIV SMVKANAYGH GVKDCLAALN    50
    ASDAFGVACL QEGLEIRELG FEQPVTLIEG VFSEDEMPVA IEQKFECVIH 100
    HQQQFEWLIK HKQAYIAQGL KVWVKLNSGM NRLGFKDPEI IEVIKTLKSE 150
    GFTCVLAMHF ANADVDHPLN EQQKQQFLHI KETCDPILAS CCNSAAIFKW 200
    PELNFDYVRP GIMLYGASPF ADKTVHDLDL KPVMTFTAEI IALNHIEAGE 250
    HVGYGSTFCA QQAMDIAIVS IGYGDGYPRA YVKQNFVAID GKLCPVVGRV 300
    SMDMIAIDVT NTQVKLGTQV ELWGNHRLVD DVAEANGTIG YELLCRLSSR 350
    PVRQGT 356
    Length:356
    Mass (Da):39,596
    Last modified:April 5, 2011 - v1
    Checksum:iC22130CED5FD32AE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001921 Genomic DNA. Translation: ADX02946.1.
    RefSeqiYP_005513884.1. NC_017162.1.

    Genome annotation databases

    EnsemblBacteriaiADX02946; ADX02946; ABK1_1312.
    GeneIDi12104646.
    KEGGiabx:ABK1_1312.
    PATRICi47064521. VBIAciBau150852_1332.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001921 Genomic DNA. Translation: ADX02946.1 .
    RefSeqi YP_005513884.1. NC_017162.1.

    3D structure databases

    ProteinModelPortali E8PI12.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADX02946 ; ADX02946 ; ABK1_1312 .
    GeneIDi 12104646.
    KEGGi abx:ABK1_1312.
    PATRICi 47064521. VBIAciBau150852_1332.

    Phylogenomic databases

    KOi K01775.
    OMAi AEININN.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci ABAU696749:GL7T-1356-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of multidrug-resistant Acinetobacter baumannii, a master of both adherence and biofilm formation."
      Kim J., Kim S.-H., Kim S.-M., Park J.-Y., Lee H.-W., Shin J.-H.
      Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1656-2Imported.

    Entry informationi

    Entry nameiE8PI12_ACIB1
    AccessioniPrimary (citable) accession number: E8PI12
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3