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E8NYH0

- E8NYH0_YERPH

UniProt

E8NYH0 - E8NYH0_YERPH

Protein

Thymidine kinase

Gene

tdk

Organism
Yersinia pestis bv. Medievalis (strain Harbin 35)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei88 – 881Proton acceptorUniRule annotation
    Metal bindingi145 – 1451ZincUniRule annotation
    Metal bindingi147 – 1471ZincUniRule annotation
    Metal bindingi182 – 1821ZincUniRule annotation
    Metal bindingi185 – 1851ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 168ATPUniRule annotation
    Nucleotide bindingi87 – 904ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciYPES547048:GLMW-2048-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotationImported
    Ordered Locus Names:YPC_2131Imported
    OrganismiYersinia pestis bv. Medievalis (strain Harbin 35)Imported
    Taxonomic identifieri547048 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000008088: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiE8NYH0.

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE8NYH0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    KOiK00857.
    OMAiELKTVCH.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E8NYH0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQLYFYYSA MNAGKSTALL QSSYNYQERG MRTLVFTAEI DNRFGVGTVS    50
    SRIGLSSQAQ LYNSGTSLLS IIAAEHQDTP IHCILLDECQ FLTKEQVQEL 100
    CQVVDELHLP VLCYGLRTDF LGELFPGSKY LLAWADKLVE LKTICHCGRK 150
    ANMVLRLDEQ GRAVHNGEQV VIGGNESYVS VCRRHYKEAI KAACCS 196
    Length:196
    Mass (Da):21,897
    Last modified:April 5, 2011 - v1
    Checksum:iF3333069CBFA5958
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001608 Genomic DNA. Translation: ADV98716.1.
    RefSeqiYP_005624003.1. NC_017265.1.

    Genome annotation databases

    EnsemblBacteriaiADV98716; ADV98716; YPC_2131.
    GeneIDi12279956.
    KEGGiyph:YPC_2131.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001608 Genomic DNA. Translation: ADV98716.1 .
    RefSeqi YP_005624003.1. NC_017265.1.

    3D structure databases

    ProteinModelPortali E8NYH0.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi E8NYH0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADV98716 ; ADV98716 ; YPC_2131 .
    GeneIDi 12279956.
    KEGGi yph:YPC_2131.

    Phylogenomic databases

    KOi K00857.
    OMAi ELKTVCH.

    Enzyme and pathway databases

    BioCyci YPES547048:GLMW-2048-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Yersinia pestis Harbin 35, complete genome."
      Plunkett G.III., Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Han C.S., Bruce D.C., Detter J.C., Tapia R., Brettin T.S., Mane S.P., Sobral B.W.
      Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Harbin 35Imported.

    Entry informationi

    Entry nameiE8NYH0_YERPH
    AccessioniPrimary (citable) accession number: E8NYH0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3