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Protein

Thymidine kinase

Gene

tdk

Organism
Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871Proton acceptorUniRule annotation
Metal bindingi143 – 1431ZincUniRule annotation
Metal bindingi146 – 1461ZincUniRule annotation
Metal bindingi181 – 1811ZincUniRule annotation
Metal bindingi184 – 1841ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 208ATPUniRule annotation
Nucleotide bindingi86 – 894ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciATHE926569:GH0F-1444-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:ANT_14160Imported
OrganismiAnaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)Imported
Taxonomic identifieri926569 [NCBI]
Taxonomic lineageiBacteriaChloroflexiAnaerolineaeAnaerolinealesAnaerolineaceaeAnaerolinea
ProteomesiUP000008922 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi926569.ANT_14160.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076390.
KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8N4T0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHTTGSIEV ITGSMFSGKT DELIRRLRRA RIARQKVQVF KPIIDDRYSV
60 70 80 90 100
EKVTSHAGNE FEAYPISRSE EIWQKLDPEA SVVAIDEAQF FDEGIVGVVQ
110 120 130 140 150
ALASKGVRVI VAGLDMDFRG EPFGVMPVLM AIAERVDKLQ AICMVCGEPA
160 170 180 190
SRTQRLVNGK PAKYSDPVVI VGASELYEAR CRQHHEVPKE
Length:190
Mass (Da):21,143
Last modified:April 5, 2011 - v1
Checksum:iC24A2C9D6444C40F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012029 Genomic DNA. Translation: BAJ63444.1.
RefSeqiWP_013559826.1. NC_014960.1.
YP_004174044.1. NC_014960.1.

Genome annotation databases

EnsemblBacteriaiBAJ63444; BAJ63444; ANT_14160.
KEGGiatm:ANT_14160.
PATRICi46854624. VBIAnaThe181647_1475.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012029 Genomic DNA. Translation: BAJ63444.1.
RefSeqiWP_013559826.1. NC_014960.1.
YP_004174044.1. NC_014960.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi926569.ANT_14160.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAJ63444; BAJ63444; ANT_14160.
KEGGiatm:ANT_14160.
PATRICi46854624. VBIAnaThe181647_1475.

Phylogenomic databases

HOGENOMiHOG000076390.
KOiK00857.

Enzyme and pathway databases

BioCyciATHE926569:GH0F-1444-MONOMER.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Whole genome sequence of Anaerolinea thermophila UNI-1."
    Narita-Yamada S., Kishi E., Watanabe Y., Takasaki K., Ankai A., Oguchi A., Fukui S., Takahashi M., Yashiro I., Hosoyama A., Sekiguchi Y., Hanada S., Fujita N.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1Imported.

Entry informationi

Entry nameiE8N4T0_ANATU
AccessioniPrimary (citable) accession number: E8N4T0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 24, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.