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Protein

Thymidine kinase

Gene

tdk

Organism
Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei87Proton acceptorUniRule annotation1
Metal bindingi143ZincUniRule annotation1
Metal bindingi146ZincUniRule annotation1
Metal bindingi181ZincUniRule annotation1
Metal bindingi184ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 20ATPUniRule annotation8
Nucleotide bindingi86 – 89ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:ANT_14160Imported
OrganismiAnaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)Imported
Taxonomic identifieri926569 [NCBI]
Taxonomic lineageiBacteriaChloroflexiAnaerolineaeAnaerolinealesAnaerolineaceaeAnaerolinea
Proteomesi
  • UP000008922 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi926569.ANT_14160

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107T8J Bacteria
COG1435 LUCA
HOGENOMiHOG000076390
KOiK00857
OMAiKEQFGWI
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

E8N4T0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHTTGSIEV ITGSMFSGKT DELIRRLRRA RIARQKVQVF KPIIDDRYSV
60 70 80 90 100
EKVTSHAGNE FEAYPISRSE EIWQKLDPEA SVVAIDEAQF FDEGIVGVVQ
110 120 130 140 150
ALASKGVRVI VAGLDMDFRG EPFGVMPVLM AIAERVDKLQ AICMVCGEPA
160 170 180 190
SRTQRLVNGK PAKYSDPVVI VGASELYEAR CRQHHEVPKE
Length:190
Mass (Da):21,143
Last modified:April 5, 2011 - v1
Checksum:iC24A2C9D6444C40F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012029 Genomic DNA Translation: BAJ63444.1

Genome annotation databases

EnsemblBacteriaiBAJ63444; BAJ63444; ANT_14160
KEGGiatm:ANT_14160

Similar proteinsi

Entry informationi

Entry nameiE8N4T0_ANATU
AccessioniPrimary (citable) accession number: E8N4T0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 28, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health