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E8N4T0

- E8N4T0_ANATU

UniProt

E8N4T0 - E8N4T0_ANATU

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Protein

Thymidine kinase

Gene
tdk, ANT_14160
Organism
Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871Proton acceptor By similarityUniRule annotation
Metal bindingi143 – 1431Zinc By similarityUniRule annotation
Metal bindingi146 – 1461Zinc By similarityUniRule annotation
Metal bindingi181 – 1811Zinc By similarityUniRule annotation
Metal bindingi184 – 1841Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 208ATP By similarityUniRule annotation
Nucleotide bindingi86 – 894ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciATHE926569:GH0F-1444-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:ANT_14160Imported
OrganismiAnaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)Imported
Taxonomic identifieri926569 [NCBI]
Taxonomic lineageiBacteriaChloroflexiAnaerolineaeAnaerolinealesAnaerolineaceaeAnaerolinea
ProteomesiUP000008922: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000076390.
KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8N4T0-1 [UniParc]FASTAAdd to Basket

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MKHTTGSIEV ITGSMFSGKT DELIRRLRRA RIARQKVQVF KPIIDDRYSV    50
EKVTSHAGNE FEAYPISRSE EIWQKLDPEA SVVAIDEAQF FDEGIVGVVQ 100
ALASKGVRVI VAGLDMDFRG EPFGVMPVLM AIAERVDKLQ AICMVCGEPA 150
SRTQRLVNGK PAKYSDPVVI VGASELYEAR CRQHHEVPKE 190
Length:190
Mass (Da):21,143
Last modified:April 5, 2011 - v1
Checksum:iC24A2C9D6444C40F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012029 Genomic DNA. Translation: BAJ63444.1.
RefSeqiWP_013559826.1. NC_014960.1.
YP_004174044.1. NC_014960.1.

Genome annotation databases

EnsemblBacteriaiBAJ63444; BAJ63444; ANT_14160.
GeneIDi10170486.
KEGGiatm:ANT_14160.
PATRICi46854624. VBIAnaThe181647_1475.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012029 Genomic DNA. Translation: BAJ63444.1 .
RefSeqi WP_013559826.1. NC_014960.1.
YP_004174044.1. NC_014960.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAJ63444 ; BAJ63444 ; ANT_14160 .
GeneIDi 10170486.
KEGGi atm:ANT_14160.
PATRICi 46854624. VBIAnaThe181647_1475.

Phylogenomic databases

HOGENOMi HOG000076390.
KOi K00857.

Enzyme and pathway databases

BioCyci ATHE926569:GH0F-1444-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequence of Anaerolinea thermophila UNI-1."
    Narita-Yamada S., Kishi E., Watanabe Y., Takasaki K., Ankai A., Oguchi A., Fukui S., Takahashi M., Yashiro I., Hosoyama A., Sekiguchi Y., Hanada S., Fujita N.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1.

Entry informationi

Entry nameiE8N4T0_ANATU
AccessioniPrimary (citable) accession number: E8N4T0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 3, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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