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E8N4H9 (E8N4H9_ANATU) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length370 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201 SAAS SAAS020622

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201 SAAS SAAS020622

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family. HAMAP-Rule MF_01201 RuleBase RU004188

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site371Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
Active site2641Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
Binding site1351Substrate By similarity HAMAP-Rule MF_01201
Binding site3101Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue371N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence LengthMass (Da)Tools
E8N4H9 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: FC8BDF6496F05D7D

FASTA37040,758
        10         20         30         40         50         60 
MDHADLTTWL EIDLSVIRKN IRLLQEIAGV PVMAVVKANA YGHGLIEASR AAVQAGVQWL 

        70         80         90        100        110        120 
GVARIDEALE LHRAGIRAHP IVLGYTPPER AGEAAQAGVR LAVYDSQVAQ AYAAQAKAVG 

       130        140        150        160        170        180 
KPLYVHAKFD TGMGRLGASP EEGVEWMRWL HTLEGLQVEG AFTHLAEADD PQKPTTHWQL 

       190        200        210        220        230        240 
DRFDKLLSGL ESAGLRPAWV HAANSAGALY FPRARYNLVR TGIAIYGLNP SAHAPLPEGF 

       250        260        270        280        290        300 
RPALTWKTRL TSVKIFPPNH GISYNYRYRT KSEERIGVCA VGYADGFRRQ MGNMVLVRGR 

       310        320        330        340        350        360 
RVPVVGSVCM DQCMVNLDQV PEAQMGDEVV LIGQQGNDEI TAEERAHEWG TIHYEVVCGL 

       370 
ANRLPRIYVE 

« Hide

References

[1]"Whole genome sequence of Anaerolinea thermophila UNI-1."
Narita-Yamada S., Kishi E., Watanabe Y., Takasaki K., Ankai A., Oguchi A., Fukui S., Takahashi M., Yashiro I., Hosoyama A., Sekiguchi Y., Hanada S., Fujita N.
Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP012029 Genomic DNA. Translation: BAJ63343.1.
RefSeqYP_004173943.1. NC_014960.1.

3D structure databases

ProteinModelPortalE8N4H9.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAJ63343; BAJ63343; ANT_13110.
GeneID10172577.
KEGGatm:ANT_13110.
PATRIC46854403. VBIAnaThe181647_1367.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000031444.
KOK01775.

Enzyme and pathway databases

BioCycATHE926569:GH0F-1337-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE8N4H9_ANATU
AccessionPrimary (citable) accession number: E8N4H9
Entry history
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)