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E8MVJ0 (E8MVJ0_BIFL1) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1 HAMAP-Rule MF_00223
EC=3.5.4.16 HAMAP-Rule MF_00223
Alternative name(s):
GTP cyclohydrolase I HAMAP-Rule MF_00223
Gene names
Name:folE HAMAP-Rule MF_00223
Ordered Locus Names:BLIF_1647 EMBL BAJ71784.1
OrganismBifidobacterium longum subsp. infantis (strain 157F) [Complete proteome] [HAMAP]
Taxonomic identifier565040 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium ›

Protein attributes

Sequence length199 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223 SAAS SAAS001474

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223 SAAS SAAS001474

Subunit structure

Homopolymer By similarity. HAMAP-Rule MF_00223

Sequence similarities

Belongs to the GTP cyclohydrolase I family. HAMAP-Rule MF_00223

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding891Zinc By similarity HAMAP-Rule MF_00223
Metal binding921Zinc By similarity HAMAP-Rule MF_00223
Metal binding1611Zinc By similarity HAMAP-Rule MF_00223

Sequences

Sequence LengthMass (Da)Tools
E8MVJ0 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: CA13EF953DBF42DD

FASTA19922,301
        10         20         30         40         50         60 
MNEYIESCHR EKRTYDEEGV REAVRLFLKS IGEDPEREGL VETPDRIARA CRELFAGLQA 

        70         80         90        100        110        120 
SPADVLEKHF DVDTDELVLV KDIELYSVCE HHLLPFHGVA HVGYIPAKDG VMGLSKLARL 

       130        140        150        160        170        180 
VEVYARRPQV QERLTQQIAD ALVEYAGARG VIVVTECEHL CMSMRGIKKS SARTVTSAVR 

       190 
GLLRNPATRA EAMSLILDK

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References

[1]"Bifidobacteria can protect from enteropathogenic infection through production of acetate."
Fukuda S., Toh H., Hase K., Oshima K., Nakanishi Y., Yoshimura K., Tobe T., Clarke J.M., Topping D.L., Suzuki T., Taylor T.D., Itoh K., Kikuchi J., Morita H., Hattori M., Ohno H.
Nature 469:543-547(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 157F EMBL BAJ71784.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP010890 Genomic DNA. Translation: BAJ71784.1.
RefSeqYP_004209562.1. NC_015052.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAJ71784; BAJ71784; BLIF_1647.
GeneID10208331.
KEGGblf:BLIF_1647.
PATRIC46887391. VBIBifLon182273_1685.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000221222.
KOK01495.
OMALYSVCEH.

Enzyme and pathway databases

BioCycBLON565040:GHFW-1685-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR020602. GTP_CycHdrlase_I/CN_OxRdtase.
IPR018234. GTP_CycHdrlase_I_CS.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE8MVJ0_BIFL1
AccessionPrimary (citable) accession number: E8MVJ0
Entry history
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: May 29, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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