E8MGQ9 (E8MGQ9_BIFL2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolase PIRNR PIRNR001361
EC=2.5.1.54 PIRNR PIRNR001361

Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase PIRNR PIRNR001361
DAHP synthase PIRNR PIRNR001361
Phospho-2-keto-3-deoxyheptonate aldolase PIRNR PIRNR001361

Gene names

Ordered Locus Names:

BLLJ_0292 EMBL BAJ65962.1

Organism

Bifidobacterium longum subsp. longum (strain ATCC 15707 / DSM 20219 / JCM 1217 / NCTC 11818 / E194b) [Complete proteome] [HAMAP]

Taxonomic identifier

565042 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium › Bifidobacterium longum › Bifidobacterium longum subsp. longum

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) By similarity. PIRNR PIRNR001361
Catalytic activity	Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate. PIRNR PIRNR001361
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7. PIRNR PIRNR001361
Sequence similarities	Belongs to the class-I DAHP synthase family. PIRNR PIRNR001361

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis PIRNR PIRNR001361
Molecular function	Transferase PIRNR PIRNR001361
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW chorismate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	3-deoxy-7-phosphoheptulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E8MGQ9 [UniParc]. Last modified April 5, 2011. Version 1. Checksum: 30269EDF21B4A611	FASTA	377	41,413
	10 20 30 40 50 60 MAALRGPDSS EDERRLGEQA VFPETVDVNI RQLDPIPAPR AFLREQPLTD EMSELVLHSR 70 80 90 100 110 120 QEIRDVLNGR DDRLLVIVGP CSIHDPKAAH EYAEKLAAVK RELEDRLVIV MRVYFEKPRT 130 140 150 160 170 180 TIGWKGLIND PDLDGRFNIR KGMWLARKVL TDVLSLGLPA ATEWLDPITP QYICDAISWG 190 200 210 220 230 240 AIGARNTESQ VHRELASGLS MPVGFKNSTD GSIKAAADSC FAAGFEHHFL SINLDGRVIS 250 260 270 280 290 300 AETKGNPDCH LVLRGSSHGP NYDAESVRQA LEDLKVSKAS GPSQHGLVID AAHGNCGKDE 310 320 330 340 350 360 NREAEVIEEI AERLAHGEQG ITGVMMESFL VGGHQKPAPL DQLVYGQSVT DSCVPWERTN 370 ELLHTLADAV TARRSAK

References

[1]

"Bifidobacteria can protect from enteropathogenic infection through production of acetate." Fukuda S., Toh H., Hase K., Oshima K., Nakanishi Y., Yoshimura K., Tobe T., Clarke J.M., Topping D.L., Suzuki T., Taylor T.D., Itoh K., Kikuchi J., Morita H., Hattori M., Ohno H. Nature 469:543-547(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15707 / DSM 20219 / JCM 1217 / NCTC 11818 / E194b.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP010888 Genomic DNA. Translation: BAJ65962.1.
RefSeq	YP_004220054.1. NC_015067.1.
3D structure databases
ProteinModelPortal	E8MGQ9.
SMR	E8MGQ9. Positions 27-374.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAJ65962; BAJ65962; BLLJ_0292.
GeneID	10209058.
KEGG	blm:BLLJ_0292.
PATRIC	46888834. VBIBifLon48544_0301.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000220501.
KO	K01626.
OMA	LITMRVY.
Enzyme and pathway databases
BioCyc	BLON565042:GIWN-292-MONOMER.
UniPathway	UPA00053; UER00084.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006219. DHAP_synth_1. [Graphical view]
PANTHER	PTHR21225. PTHR21225. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
PIRSF	PIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMs	TIGR00034. aroFGH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

E8MGQ9_BIFL2

Accession

Primary (citable) accession number: E8MGQ9

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	May 1, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)