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E7R7R2

- KEX1_OGAPD

UniProt

E7R7R2 - KEX1_OGAPD

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Ogataea parapolymorpha (strain DL-1 / ATCC 26012 / NRRL Y-7560) (Yeast) (Hansenula polymorpha)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei176 – 1761By similarity
    Active sitei371 – 3711By similarity
    Active sitei429 – 4291By similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    ORF Names:HPODL_04558
    OrganismiOgataea parapolymorpha (strain DL-1 / ATCC 26012 / NRRL Y-7560) (Yeast) (Hansenula polymorpha)
    Taxonomic identifieri871575 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetales incertae sedisOgataea
    ProteomesiUP000008673: Chromosome II, UP000008673: Partially assembled WGS

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 610592Pheromone-processing carboxypeptidase KEX1PRO_0000411937Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi426 – 4261N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliE7R7R2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 494476LumenalSequence AnalysisAdd
    BLAST
    Topological domaini516 – 61095CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei495 – 51521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi481 – 4866Poly-Glu
    Compositional biasi533 – 5375Poly-Lys

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    E7R7R2-1 [UniParc]FASTAAdd to Basket

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    MSRYFLLACT LALQCVAASQ EDYIVKDLPG LSNIPAVVRP VMHAGHLEID    50
    EEHNTELFFW RFQNPKNNGT HQTLHRNELI VWLNGGPGCS SMDGAMMETG 100
    PLRVSDKLEV ELNPGSWTQV ADILFVDQPA GTGFSYTDSY DTELKQAAQH 150
    FWQFLKTYYQ LFPEDRTKKL YLAGESYAGQ YIPYFAKEII ENNSLNISLE 200
    GLLIGNGWID PDIQSLSYVP FSLEAGFLDR QSPSMAQVLK QHEKCQQAID 250
    DPSNHDFEKV ECVKIFHSIL AASRDETKPA KEQCVNMYDY RKHDYFPACG 300
    SNWPEGLPTV TKFLNLDAVQ KALNLKSAKR WHECDGKVEF FFQPEHSVKS 350
    FDLLPKLLEK MKIALFAGDK DIICNHKSIE MVIEKLQITP GQFGFTNSRK 400
    SGWIYDGQEV GEVETQSNLT YIKVFNSSHM VPYDLPEVSR GLFDIITNSI 450
    EKRSTDIVTP VYDSRGNYKF VEEKQDTDQN EEEEKEKPPK HHHSLTFYVA 500
    EVAILAVLAY LLYSFYKSFA KSRKSAFLSL SSKKKKKQVH WFDESDIGMD 550
    QEAGEADHKP KSMLESVFNK LGYGGQYDTV QDGRDIEMAP VEEHEDQFII 600
    QSDEEEFGHR 610
    Length:610
    Mass (Da):69,724
    Last modified:April 5, 2011 - v1
    Checksum:iB31CC03D8132DA5F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF090325 Genomic DNA. Translation: AAQ13482.1.
    AEOI02000004 Genomic DNA. Translation: ESX01783.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF090325 Genomic DNA. Translation: AAQ13482.1 .
    AEOI02000004 Genomic DNA. Translation: ESX01783.1 .

    3D structure databases

    ProteinModelPortali E7R7R2.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the KEX1 gene encoding carboxypeptidase B-like protease from Hansenula polymorpha."
      Bae J.-H., Sohn J.-H., Kang H.-A., Choi E.-S., Rhee S.-K.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 26012 / NRRL Y-7560 / DL-1.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 26012 / NRRL Y-7560 / DL-1.

    Entry informationi

    Entry nameiKEX1_OGAPD
    AccessioniPrimary (citable) accession number: E7R7R2
    Secondary accession number(s): A1IMC1, W1QIR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3