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E7R7R2

- KEX1_OGAPD

UniProt

E7R7R2 - KEX1_OGAPD

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Protein
Pheromone-processing carboxypeptidase KEX1
Gene
KEX1, HPODL_04558
Organism
Ogataea parapolymorpha (strain DL-1 / ATCC 26012 / NRRL Y-7560) (Yeast) (Hansenula polymorpha)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei176 – 1761 By similarity
Active sitei371 – 3711 By similarity
Active sitei429 – 4291 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:HPODL_04558
OrganismiOgataea parapolymorpha (strain DL-1 / ATCC 26012 / NRRL Y-7560) (Yeast) (Hansenula polymorpha)
Taxonomic identifieri871575 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetales incertae sedisOgataea
ProteomesiUP000008673: Chromosome II, UP000008673: Partially assembled WGS

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 494476Lumenal Reviewed prediction
Add
BLAST
Transmembranei495 – 51521Helical; Reviewed prediction
Add
BLAST
Topological domaini516 – 61095Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 610592Pheromone-processing carboxypeptidase KEX1
PRO_0000411937Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi68 – 681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi192 – 1921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi196 – 1961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi418 – 4181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi426 – 4261N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliE7R7R2.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi481 – 4866Poly-Glu
Compositional biasi533 – 5375Poly-Lys

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E7R7R2-1 [UniParc]FASTAAdd to Basket

« Hide

MSRYFLLACT LALQCVAASQ EDYIVKDLPG LSNIPAVVRP VMHAGHLEID    50
EEHNTELFFW RFQNPKNNGT HQTLHRNELI VWLNGGPGCS SMDGAMMETG 100
PLRVSDKLEV ELNPGSWTQV ADILFVDQPA GTGFSYTDSY DTELKQAAQH 150
FWQFLKTYYQ LFPEDRTKKL YLAGESYAGQ YIPYFAKEII ENNSLNISLE 200
GLLIGNGWID PDIQSLSYVP FSLEAGFLDR QSPSMAQVLK QHEKCQQAID 250
DPSNHDFEKV ECVKIFHSIL AASRDETKPA KEQCVNMYDY RKHDYFPACG 300
SNWPEGLPTV TKFLNLDAVQ KALNLKSAKR WHECDGKVEF FFQPEHSVKS 350
FDLLPKLLEK MKIALFAGDK DIICNHKSIE MVIEKLQITP GQFGFTNSRK 400
SGWIYDGQEV GEVETQSNLT YIKVFNSSHM VPYDLPEVSR GLFDIITNSI 450
EKRSTDIVTP VYDSRGNYKF VEEKQDTDQN EEEEKEKPPK HHHSLTFYVA 500
EVAILAVLAY LLYSFYKSFA KSRKSAFLSL SSKKKKKQVH WFDESDIGMD 550
QEAGEADHKP KSMLESVFNK LGYGGQYDTV QDGRDIEMAP VEEHEDQFII 600
QSDEEEFGHR 610
Length:610
Mass (Da):69,724
Last modified:April 5, 2011 - v1
Checksum:iB31CC03D8132DA5F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF090325 Genomic DNA. Translation: AAQ13482.1.
AEOI02000004 Genomic DNA. Translation: ESX01783.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF090325 Genomic DNA. Translation: AAQ13482.1 .
AEOI02000004 Genomic DNA. Translation: ESX01783.1 .

3D structure databases

ProteinModelPortali E7R7R2.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the KEX1 gene encoding carboxypeptidase B-like protease from Hansenula polymorpha."
    Bae J.-H., Sohn J.-H., Kang H.-A., Choi E.-S., Rhee S.-K.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 26012 / NRRL Y-7560 / DL-1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 26012 / NRRL Y-7560 / DL-1.

Entry informationi

Entry nameiKEX1_OGAPD
AccessioniPrimary (citable) accession number: E7R7R2
Secondary accession number(s): A1IMC1, W1QIR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 5, 2011
Last modified: June 11, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3