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E7R7R2

- KEX1_OGAPD

UniProt

E7R7R2 - KEX1_OGAPD

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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Ogataea parapolymorpha (strain DL-1 / ATCC 26012 / NRRL Y-7560) (Yeast) (Hansenula polymorpha)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei176 – 1761By similarity
Active sitei371 – 3711By similarity
Active sitei429 – 4291By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:HPODL_04558
OrganismiOgataea parapolymorpha (strain DL-1 / ATCC 26012 / NRRL Y-7560) (Yeast) (Hansenula polymorpha)
Taxonomic identifieri871575 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPichiaceaeOgataea
ProteomesiUP000008673: Chromosome II, UP000008673: Partially assembled WGS

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 610592Pheromone-processing carboxypeptidase KEX1PRO_0000411937Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi426 – 4261N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliE7R7R2.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 494476LumenalSequence AnalysisAdd
BLAST
Topological domaini516 – 61095CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei495 – 51521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi481 – 4866Poly-Glu
Compositional biasi533 – 5375Poly-Lys

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E7R7R2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRYFLLACT LALQCVAASQ EDYIVKDLPG LSNIPAVVRP VMHAGHLEID
60 70 80 90 100
EEHNTELFFW RFQNPKNNGT HQTLHRNELI VWLNGGPGCS SMDGAMMETG
110 120 130 140 150
PLRVSDKLEV ELNPGSWTQV ADILFVDQPA GTGFSYTDSY DTELKQAAQH
160 170 180 190 200
FWQFLKTYYQ LFPEDRTKKL YLAGESYAGQ YIPYFAKEII ENNSLNISLE
210 220 230 240 250
GLLIGNGWID PDIQSLSYVP FSLEAGFLDR QSPSMAQVLK QHEKCQQAID
260 270 280 290 300
DPSNHDFEKV ECVKIFHSIL AASRDETKPA KEQCVNMYDY RKHDYFPACG
310 320 330 340 350
SNWPEGLPTV TKFLNLDAVQ KALNLKSAKR WHECDGKVEF FFQPEHSVKS
360 370 380 390 400
FDLLPKLLEK MKIALFAGDK DIICNHKSIE MVIEKLQITP GQFGFTNSRK
410 420 430 440 450
SGWIYDGQEV GEVETQSNLT YIKVFNSSHM VPYDLPEVSR GLFDIITNSI
460 470 480 490 500
EKRSTDIVTP VYDSRGNYKF VEEKQDTDQN EEEEKEKPPK HHHSLTFYVA
510 520 530 540 550
EVAILAVLAY LLYSFYKSFA KSRKSAFLSL SSKKKKKQVH WFDESDIGMD
560 570 580 590 600
QEAGEADHKP KSMLESVFNK LGYGGQYDTV QDGRDIEMAP VEEHEDQFII
610
QSDEEEFGHR
Length:610
Mass (Da):69,724
Last modified:April 5, 2011 - v1
Checksum:iB31CC03D8132DA5F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF090325 Genomic DNA. Translation: AAQ13482.1.
AEOI02000004 Genomic DNA. Translation: ESX01783.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF090325 Genomic DNA. Translation: AAQ13482.1 .
AEOI02000004 Genomic DNA. Translation: ESX01783.1 .

3D structure databases

ProteinModelPortali E7R7R2.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the KEX1 gene encoding carboxypeptidase B-like protease from Hansenula polymorpha."
    Bae J.-H., Sohn J.-H., Kang H.-A., Choi E.-S., Rhee S.-K.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 26012 / NRRL Y-7560 / DL-1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 26012 / NRRL Y-7560 / DL-1.

Entry informationi

Entry nameiKEX1_OGAPD
AccessioniPrimary (citable) accession number: E7R7R2
Secondary accession number(s): A1IMC1, W1QIR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 5, 2011
Last modified: October 29, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3