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Protein
Submitted name:

Neuregulin 2

Gene

nrg2b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-DRE-1227986. Signaling by ERBB2.
R-DRE-1236394. Signaling by ERBB4.
R-DRE-1250196. SHC1 events in ERBB2 signaling.
R-DRE-1257604. PIP3 activates AKT signaling.
R-DRE-1306955. GRB7 events in ERBB2 signaling.
R-DRE-1358803. Downregulation of ERBB2:ERBB3 signaling.
R-DRE-1963642. PI3K events in ERBB2 signaling.
R-DRE-5673001. RAF/MAP kinase cascade.
R-DRE-6785631. ERBB2 Regulates Cell Motility.
R-DRE-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-DRE-8847993. ERBB2 Activates PTK6 Signaling.
R-DRE-8863795. Downregulation of ERBB2 signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Neuregulin 2Imported
Submitted name:
Neuregulin 2bImported
Gene namesi
Name:nrg2bImported
Synonyms:NRG2bImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 14

Organism-specific databases

ZFINiZDB-GENE-090205-2. nrg2b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei309 – 331HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_501120568120 – 705Sequence analysisAdd BLAST686

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi254 ↔ 271PROSITE-ProRule annotation
Disulfide bondi273 ↔ 282PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

PaxDbiE7FGA4.

Expressioni

Gene expression databases

BgeeiENSDARG00000086585.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000108874.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini141 – 228Ig-likeInterPro annotationAdd BLAST88
Domaini242 – 283EGF-likeInterPro annotationAdd BLAST42

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IGZW. Eukaryota.
ENOG410Y95Z. LUCA.
GeneTreeiENSGT00900000140940.
InParanoidiE7FGA4.
OMAiQYGDSYD.
OrthoDBiEOG091G032E.
TreeFamiTF332469.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR002154. Neuregulin_C.
PfamiView protein in Pfam
PF07679. I-set. 1 hit.
PF02158. Neuregulin. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS50835. IG_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

E7FGA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRLDPVHFS MLVIGVSFAC YAPSLDSLQD QAYRSAVVIE GKVSSLPENV
60 70 80 90 100
SVEPYSVNVT VLYVWPVNSG GLRREQLVTV GEFGSEAPCV AVEKHHTYIF
110 120 130 140 150
FMDPTEEPLV FKASFAPLDS TEKTLKKDVE SVLCKDCASA PKVKPMDSQW
160 170 180 190 200
LQEGKKLTLK CEAVGNPSPS FNWYKDGSQL RQKKTVKIKT NKKNSKLHIS
210 220 230 240 250
KVRLEDSGNY TCVVENSLGR ENATSFVSVQ SITTTLSPGS SHARKCNETE
260 270 280 290 300
KTYCINGGDC YFIHGINQLS CKCPNDYTGE RCQTSVMAGF YKHLGIEIME
310 320 330 340 350
AEELYQKRVL TITGICVALL VVGIVCVVAY CKTKKQRKKM HNHLHQNMCA
360 370 380 390 400
EHPNRMLANG PNHPGPGPEE IPMVDYISKN VPATERVVRH GTETSGNFSG
410 420 430 440 450
SRMSSRSHHT STASHTSSHR HEERTWSMER TDSIHSDCQS GALSSSVGTS
460 470 480 490 500
KCSSPACMEA RARRAAYCGY PDATQCSLQY GDSYDSLRDS PHSDRYVSAL
510 520 530 540 550
TTPARLSPVD FHSSLPPQVP TFQITTPNAS HALSLPPAAS AIAMAAYSPD
560 570 580 590 600
DDQPLLYRYR RSRRPYYAAE STGSLPSSPY RFVDDEDYET TQEYMSSREQ
610 620 630 640 650
PKKSSGSRRW RRRSRINGHT PGPRNYSSQS CLSDSEWEDE EVGDLGHGES
660 670 680 690 700
TPFLSMQNMN ATEPATIYRP NDTRTFSNTG RSGSRPNVQA NKLTQSRFRP

DNAPL
Length:705
Mass (Da):78,341
Last modified:January 20, 2016 - v2
Checksum:iD6BEBC60DDB6C192
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX005008 Genomic DNA. No translation available.
BX323592 Genomic DNA. No translation available.
CR407701 Genomic DNA. No translation available.
KT023305 mRNA. Translation: AKS25897.1.
RefSeqiXP_005157176.1. XM_005157119.3.
UniGeneiDr.117716.

Genome annotation databases

EnsembliENSDART00000129055; ENSDARP00000108874; ENSDARG00000086585.
GeneIDi100270726.

Similar proteinsi

Entry informationi

Entry nameiE7FGA4_DANRE
AccessioniPrimary (citable) accession number: E7FGA4
Secondary accession number(s): A0A0K0WSF9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: January 20, 2016
Last modified: November 22, 2017
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported