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Protein
Submitted name:

ATPase copper-transporting beta

Gene

atp7b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi17PROSITE-ProRule annotation1
Metal bindingi20PROSITE-ProRule annotation1
Metal bindingi99PROSITE-ProRule annotation1
Metal bindingi102PROSITE-ProRule annotation1
Metal bindingi184PROSITE-ProRule annotation1
Metal bindingi187PROSITE-ProRule annotation1
Metal bindingi312PROSITE-ProRule annotation1
Metal bindingi315PROSITE-ProRule annotation1
Metal bindingi388PROSITE-ProRule annotation1
Metal bindingi391PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
LigandMetal-bindingPROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Submitted name:
ATPase copper-transporting betaImported
Gene namesi
Name:atp7bImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 6

Organism-specific databases

ZFINiZDB-GENE-061220-5 atp7b

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei467 – 486HelicalUniRule annotationAdd BLAST20
Transmembranei506 – 526HelicalUniRule annotationAdd BLAST21
Transmembranei547 – 569HelicalUniRule annotationAdd BLAST23
Transmembranei575 – 596HelicalUniRule annotationAdd BLAST22
Transmembranei739 – 763HelicalUniRule annotationAdd BLAST25
Transmembranei783 – 806HelicalUniRule annotationAdd BLAST24
Transmembranei1143 – 1165HelicalUniRule annotationAdd BLAST23
Transmembranei1171 – 1194HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSDARG00000058145
ExpressionAtlasiE7FDM8 baseline

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 73HMAInterPro annotationAdd BLAST67
Domaini89 – 158HMAInterPro annotationAdd BLAST70
Domaini174 – 240HMAInterPro annotationAdd BLAST67
Domaini302 – 368HMAInterPro annotationAdd BLAST67
Domaini378 – 444HMAInterPro annotationAdd BLAST67

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG0207 Eukaryota
COG2217 LUCA
GeneTreeiENSGT00530000063773
InParanoidiE7FDM8
TreeFamiTF300460

Family and domain databases

CDDicd00371 HMA, 5 hits
Gene3Di3.40.1110.10, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR017969 Heavy-metal-associated_CS
IPR006122 HMA_Cu_ion-bd
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00403 HMA, 5 hits
SUPFAMiSSF55008 SSF55008, 5 hits
SSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 2 hits
TIGR00003 TIGR00003, 5 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 4 hits
PS50846 HMA_2, 5 hits

Sequencei

Sequence statusi: Complete.

E7FDM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LPSEEGMVKI QVEGMTCQSC VRSIEEQIGR LEGVIGVQVS LSDKEAILRF
60 70 80 90 100
NPAKVTPEDM RKRIEDMGFD ALILALQGQI QPLSTDWSEV TLGVEGMHCG
110 120 130 140 150
SCVKNITETL SGMLGVNSVF VSLEKGSVDL RFDPSLLTLE TVKGFLEEIP
160 170 180 190 200
PGNFRVSIPG WSSRLNSAST PTQSVTIGIE GMTCNSCVQA IEGMMSQRAG
210 220 230 240 250
VCSIKVYLQE KKGIVTFDST VTCPEELRAE IEDMGFEAWL NQAMCSYSTD
260 270 280 290 300
ANAYSEICEV SSVSQMPSGL KHLPSQRHPS KPSPSPITKE NADGTGEREL
310 320 330 340 350
RKCFVHVTGM TCASCVSNIE RNLVKHEGIK SVLVALMAGK AEVKYDPGLL
360 370 380 390 400
DPAQIVQLIS HLGFGASVME EHSVQDGVLD LSVTGMTCAS CVHNIESKLL
410 420 430 440 450
RTKGIQEASV ALATNKAHVK FDSDLVGSRD IVRIIEGLGF GVSLIKNEGL
460 470 480 490 500
NNTLDHQEEI RQWKHSFLFS LVFGIPVMGL MIYMMVMDSQ HKEHGGSMPA
510 520 530 540 550
DQNILPGLSI INLAFFLLCT PVQFLGGRYF YIQAYRSLRH GVANMDVLIV
560 570 580 590 600
LATTIAYVYS FTVLIVAMIE GAKQSPLTFF DTPPMLFVFI ALGRWLEHVA
610 620 630 640 650
KSKTSEALAK LMSLQATDAT IVSLGPDNTI IREEQVSVDL VQRGDVVKVA
660 670 680 690 700
PGGKFPVDGK VIEGTSMADE SLITGEPMPV IKKAGSCVIA GSINAHGALL
710 720 730 740 750
VEATHVGSET TLSQIVKLVE EAQTSKAPIQ QLADKLSGYF VPFIVVISIL
760 770 780 790 800
TVTAWLIIGF LDFDVVSKNF PGYNQNISRT EVIVRFAFQA SITVLSIACP
810 820 830 840 850
CSLGLATPTA VMVGTGVGAQ NGILIKGGEP LEMAHKVGAV MFDKTGTITN
860 870 880 890 900
GVPQVTRVLV LWDRARLPLR TVLAVVGTAE ASSEHPLGMA VAKHCKEELG
910 920 930 940 950
AETLGFCHDF QAVPGCGISC KVSSVEDLLQ NSPKTQETKA SAVKQTPLLV
960 970 980 990 1000
TLQGVTTDSP SYSVLIGNRQ WMLRNGLEVT ADVDNAMSSH ETKGQTAILV
1010 1020 1030 1040 1050
AIDGVLCAMI AVADTVKAES ALAVHTLSSM GIEVYMITGD NRRTARAIAT
1060 1070 1080 1090 1100
QVGIRKVFAE VLPSHKVAKV QELQERGLKV AMVGDGVNDS PALAHADLGI
1110 1120 1130 1140 1150
AIGTGTDVAI EAADIVLIRN DLLDVVASIE LSKKTVQRIR INFVFALIYN
1160 1170 1180 1190 1200
LLGIPFAAGV FMPLGLVLQP WMGSAAMAAS SVSVVLSSLL LRLFKKTSVE
1210 1220
EYESRAQSHK LSLSPSQVST HVGLESR
Length:1,227
Mass (Da):131,745
Last modified:January 20, 2016 - v2
Checksum:i89DB77728E75E762
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX511272 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSDART00000030246; ENSDARP00000029666; ENSDARG00000058145

Similar proteinsi

Entry informationi

Entry nameiE7FDM8_DANRE
AccessioniPrimary (citable) accession number: E7FDM8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: January 20, 2016
Last modified: March 28, 2018
This is version 61 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health