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Protein
Submitted name:

ATPase, Cu++-transporting, beta polypeptide (Wilson disease)

Gene

atp7b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi17PROSITE-ProRule annotation1
Metal bindingi20PROSITE-ProRule annotation1
Metal bindingi99PROSITE-ProRule annotation1
Metal bindingi102PROSITE-ProRule annotation1
Metal bindingi184PROSITE-ProRule annotation1
Metal bindingi187PROSITE-ProRule annotation1
Metal bindingi312PROSITE-ProRule annotation1
Metal bindingi315PROSITE-ProRule annotation1
Metal bindingi388PROSITE-ProRule annotation1
Metal bindingi391PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
LigandMetal-bindingPROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Submitted name:
ATPase, Cu++-transporting, beta polypeptide (Wilson disease)Imported
Gene namesi
Name:atp7bImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 6

Organism-specific databases

ZFINiZDB-GENE-061220-5. atp7b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei467 – 486HelicalUniRule annotationAdd BLAST20
Transmembranei506 – 526HelicalUniRule annotationAdd BLAST21
Transmembranei547 – 569HelicalUniRule annotationAdd BLAST23
Transmembranei575 – 596HelicalUniRule annotationAdd BLAST22
Transmembranei739 – 763HelicalUniRule annotationAdd BLAST25
Transmembranei783 – 806HelicalUniRule annotationAdd BLAST24
Transmembranei1143 – 1165HelicalUniRule annotationAdd BLAST23
Transmembranei1171 – 1194HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiE7FDM8.

Expressioni

Gene expression databases

BgeeiENSDARG00000058145.
ExpressionAtlasiE7FDM8. baseline.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 73HMAInterPro annotationAdd BLAST67
Domaini89 – 158HMAInterPro annotationAdd BLAST70
Domaini174 – 240HMAInterPro annotationAdd BLAST67
Domaini302 – 368HMAInterPro annotationAdd BLAST67
Domaini378 – 444HMAInterPro annotationAdd BLAST67

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG0207. Eukaryota.
COG2217. LUCA.
GeneTreeiENSGT00530000063773.
InParanoidiE7FDM8.
TreeFamiTF300460.

Family and domain databases

CDDicd00371. HMA. 5 hits.
Gene3Di3.40.1110.10. 1 hit.
3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR036412. HAD-like_sf.
IPR023214. HAD_sf.
IPR017969. Heavy-metal-associated_CS.
IPR006122. HMA_Cu_ion-bd.
IPR006121. HMA_dom.
IPR036163. HMA_dom_sf.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
PfamiView protein in Pfam
PF00403. HMA. 5 hits.
SUPFAMiSSF55008. SSF55008. 5 hits.
SSF56784. SSF56784. 2 hits.
SSF81653. SSF81653. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
TIGR00003. TIGR00003. 5 hits.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 4 hits.
PS50846. HMA_2. 5 hits.

Sequencei

Sequence statusi: Complete.

E7FDM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LPSEEGMVKI QVEGMTCQSC VRSIEEQIGR LEGVIGVQVS LSDKEAILRF
60 70 80 90 100
NPAKVTPEDM RKRIEDMGFD ALILALQGQI QPLSTDWSEV TLGVEGMHCG
110 120 130 140 150
SCVKNITETL SGMLGVNSVF VSLEKGSVDL RFDPSLLTLE TVKGFLEEIP
160 170 180 190 200
PGNFRVSIPG WSSRLNSAST PTQSVTIGIE GMTCNSCVQA IEGMMSQRAG
210 220 230 240 250
VCSIKVYLQE KKGIVTFDST VTCPEELRAE IEDMGFEAWL NQAMCSYSTD
260 270 280 290 300
ANAYSEICEV SSVSQMPSGL KHLPSQRHPS KPSPSPITKE NADGTGEREL
310 320 330 340 350
RKCFVHVTGM TCASCVSNIE RNLVKHEGIK SVLVALMAGK AEVKYDPGLL
360 370 380 390 400
DPAQIVQLIS HLGFGASVME EHSVQDGVLD LSVTGMTCAS CVHNIESKLL
410 420 430 440 450
RTKGIQEASV ALATNKAHVK FDSDLVGSRD IVRIIEGLGF GVSLIKNEGL
460 470 480 490 500
NNTLDHQEEI RQWKHSFLFS LVFGIPVMGL MIYMMVMDSQ HKEHGGSMPA
510 520 530 540 550
DQNILPGLSI INLAFFLLCT PVQFLGGRYF YIQAYRSLRH GVANMDVLIV
560 570 580 590 600
LATTIAYVYS FTVLIVAMIE GAKQSPLTFF DTPPMLFVFI ALGRWLEHVA
610 620 630 640 650
KSKTSEALAK LMSLQATDAT IVSLGPDNTI IREEQVSVDL VQRGDVVKVA
660 670 680 690 700
PGGKFPVDGK VIEGTSMADE SLITGEPMPV IKKAGSCVIA GSINAHGALL
710 720 730 740 750
VEATHVGSET TLSQIVKLVE EAQTSKAPIQ QLADKLSGYF VPFIVVISIL
760 770 780 790 800
TVTAWLIIGF LDFDVVSKNF PGYNQNISRT EVIVRFAFQA SITVLSIACP
810 820 830 840 850
CSLGLATPTA VMVGTGVGAQ NGILIKGGEP LEMAHKVGAV MFDKTGTITN
860 870 880 890 900
GVPQVTRVLV LWDRARLPLR TVLAVVGTAE ASSEHPLGMA VAKHCKEELG
910 920 930 940 950
AETLGFCHDF QAVPGCGISC KVSSVEDLLQ NSPKTQETKA SAVKQTPLLV
960 970 980 990 1000
TLQGVTTDSP SYSVLIGNRQ WMLRNGLEVT ADVDNAMSSH ETKGQTAILV
1010 1020 1030 1040 1050
AIDGVLCAMI AVADTVKAES ALAVHTLSSM GIEVYMITGD NRRTARAIAT
1060 1070 1080 1090 1100
QVGIRKVFAE VLPSHKVAKV QELQERGLKV AMVGDGVNDS PALAHADLGI
1110 1120 1130 1140 1150
AIGTGTDVAI EAADIVLIRN DLLDVVASIE LSKKTVQRIR INFVFALIYN
1160 1170 1180 1190 1200
LLGIPFAAGV FMPLGLVLQP WMGSAAMAAS SVSVVLSSLL LRLFKKTSVE
1210 1220
EYESRAQSHK LSLSPSQVST HVGLESR
Length:1,227
Mass (Da):131,745
Last modified:January 20, 2016 - v2
Checksum:i89DB77728E75E762
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX511272 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSDART00000030246; ENSDARP00000029666; ENSDARG00000058145.

Similar proteinsi

Entry informationi

Entry nameiE7FDM8_DANRE
AccessioniPrimary (citable) accession number: E7FDM8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: January 20, 2016
Last modified: October 25, 2017
This is version 57 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported