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Protein

Nanos homolog 1

Gene

nanos1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a translational repressor. Can mediate repression affecting different steps in the translation process: cap-driven, IRES-driven, polyadenylated RNAs or nonpolyadenylated RNAs (By similarity). Essential for the development of primordial germ cells (PGCs) by ensuring their proper migration and survival.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri150 – 204Nanos-typePROSITE-ProRule annotationAdd BLAST55

GO - Molecular functioni

GO - Biological processi

  • germ cell development Source: UniProtKB
  • germ cell migration Source: UniProtKB

Keywordsi

Molecular functionRepressor, RNA-binding
Biological processTranslation regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nanos homolog 1
Gene namesi
Name:nanos1
ORF Names:wu:fb76c12
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 14

Organism-specific databases

ZFINiZDB-GENE-030131-1623 nanos1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004094471 – 228Nanos homolog 1Add BLAST228

Proteomic databases

PaxDbiE7FDB3
PRIDEiE7FDB3

Expressioni

Tissue specificityi

3'-UTR is sufficient for directing specific expression of this protein in the primordial germ cells (PGCs).1 Publication

Developmental stagei

Present in oocytes and in embryos before the 4- and 256-cell stages. Levels decline and it is barely detectable by the fifth day of development.1 Publication

Gene expression databases

BgeeiENSDARG00000078976

Interactioni

Protein-protein interaction databases

ELMiE7FDB3
STRINGi7955.ENSDARP00000098689

Structurei

3D structure databases

SMRiE7FDB3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 34Essential for its translational repressor activityBy similarityAdd BLAST16

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi151 – 178C2HC 1Add BLAST28
Motifi186 – 202C2HC 2Add BLAST17

Domaini

The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.PROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the nanos family.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri150 – 204Nanos-typePROSITE-ProRule annotationAdd BLAST55

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4602 Eukaryota
ENOG41121KZ LUCA
GeneTreeiENSGT00640000091383
InParanoidiE7FDB3
KOiK18741
OMAiMDFLNHN
OrthoDBiEOG091G0JUB
PhylomeDBiE7FDB3
TreeFamiTF326882

Family and domain databases

Gene3Di1.10.150.680, 1 hit
InterProiView protein in InterPro
IPR008705 Nanos/Xcar2
IPR038129 Nanos_sf
IPR024161 Znf_nanos-typ
PANTHERiPTHR12887 PTHR12887, 1 hit
PfamiView protein in Pfam
PF05741 zf-nanos, 1 hit
PROSITEiView protein in PROSITE
PS51522 ZF_NANOS, 1 hit

Sequencei

Sequence statusi: Complete.

E7FDB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLNHNYLS ARASYDYTFN FWNDYLGLST LVTKNSKHSV PQNPNSITES
60 70 80 90 100
LKATLGLDDS PPCPCVMGEG DSGGHLDSCC CPPPASISIL DLKERFSILS
110 120 130 140 150
PFQNQNQGSL LSSSQEREIG IGGGFAGFDL FGVERKMRKP AARNKQEPKI
160 170 180 190 200
CVFCRNNGAP EEVYGSHVLK TPDGRVVCPI LRAYTCPLCS ANGDNAHTIK
210 220
YCPLSKDQPA QRVLKGGRAV GGKRVKIF
Length:228
Mass (Da):24,861
Last modified:March 8, 2011 - v1
Checksum:i52353442B33480D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABZ01002992 Genomic DNA No translation available.
RefSeqiNP_001292590.1, NM_001305661.1
UniGeneiDr.22023

Genome annotation databases

EnsembliENSDART00000114678; ENSDARP00000098689; ENSDARG00000078976
GeneIDi322903
KEGGidre:322903

Similar proteinsi

Entry informationi

Entry nameiNANO1_DANRE
AccessioniPrimary (citable) accession number: E7FDB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: March 8, 2011
Last modified: May 23, 2018
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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