ID   A0A8M1RH12_DANRE        Unreviewed;       956 AA.
AC   A0A8M1RH12; E7FCP7;
DT   03-AUG-2022, integrated into UniProtKB/TrEMBL.
DT   03-AUG-2022, sequence version 1.
DT   27-MAR-2024, entry version 10.
DE   SubName: Full=Lysosomal alpha-glucosidase isoform X2 {ECO:0000313|RefSeq:XP_002660410.1, ECO:0000313|RefSeq:XP_005170936.1};
DE   SubName: Full=Si:ch73-12o23.1 {ECO:0000313|Ensembl:ENSDARP00000101564};
GN   Name=gaa2 {ECO:0000313|ZFIN:ZDB-GENE-130530-749};
GN   Synonyms=si:ch73-12o23.1 {ECO:0000313|RefSeq:XP_002660410.1,
GN   ECO:0000313|RefSeq:XP_005170936.1, ECO:0000313|RefSeq:XP_021331622.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Proteomes:UP000000437, ECO:0000313|RefSeq:XP_002660410.1};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000101564}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000101564};
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000101564, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000101564};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RG   Genome Reference Consortium Zebrafish;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA   Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA   Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA   Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA   Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA   Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA   Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA   Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA   Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA   Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA   Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA   Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA   Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA   Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA   Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA   Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA   Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA   Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA   Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA   Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3] {ECO:0000313|RefSeq:XP_002660410.1, ECO:0000313|RefSeq:XP_005170936.1}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_002660410.1,
RC   ECO:0000313|RefSeq:XP_005170936.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 31 family.
CC       {ECO:0000256|ARBA:ARBA00007806, ECO:0000256|RuleBase:RU361185}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00779}.
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DR   EMBL; CU104756; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU914772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002660410.1; XM_002660364.5.
DR   RefSeq; XP_005170936.1; XM_005170879.4.
DR   RefSeq; XP_021331622.1; XM_021475947.1.
DR   STRING; 7955.ENSDARP00000101564; -.
DR   PaxDb; 7955-ENSDARP00000101564; -.
DR   Ensembl; ENSDART00000110790; ENSDARP00000101564; ENSDARG00000074282.
DR   Ensembl; ENSDART00000110790.4; ENSDARP00000101564.2; ENSDARG00000074282.4.
DR   GeneID; 100332784; -.
DR   KEGG; dre:100332784; -.
DR   AGR; ZFIN:ZDB-GENE-130530-749; -.
DR   CTD; 100332784; -.
DR   ZFIN; ZDB-GENE-130530-749; gaa2.
DR   eggNOG; KOG1065; Eukaryota.
DR   HOGENOM; CLU_000631_11_2_1; -.
DR   OMA; YKGAVWP; -.
DR   OrthoDB; 5480935at2759; -.
DR   TreeFam; TF314577; -.
DR   Proteomes; UP000000437; Chromosome 1.
DR   Bgee; ENSDARG00000074282; Expressed in blastula and 21 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090599; F:alpha-glucosidase activity; IEA:UniProt.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd06602; GH31_MGAM_SI_GAA; 1.
DR   CDD; cd14752; GH31_N; 1.
DR   CDD; cd00111; Trefoil; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.1760; glycosyl hydrolase (family 31); 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 2.
DR   Gene3D; 4.10.110.10; Spasmolytic Protein, domain 1; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR030458; Glyco_hydro_31_AS.
DR   InterPro; IPR048395; Glyco_hydro_31_C.
DR   InterPro; IPR030459; Glyco_hydro_31_CS.
DR   InterPro; IPR025887; Glyco_hydro_31_N_dom.
DR   InterPro; IPR000322; Glyco_hydro_31_TIM.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR000519; P_trefoil_dom.
DR   InterPro; IPR044913; P_trefoil_dom_sf.
DR   PANTHER; PTHR22762; ALPHA-GLUCOSIDASE; 1.
DR   PANTHER; PTHR22762:SF104; P-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF13802; Gal_mutarotas_2; 1.
DR   Pfam; PF01055; Glyco_hydro_31_2nd; 1.
DR   Pfam; PF21365; Glyco_hydro_31_3rd; 1.
DR   Pfam; PF00088; Trefoil; 1.
DR   SMART; SM00018; PD; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
DR   SUPFAM; SSF57492; Trefoil; 1.
DR   PROSITE; PS00129; GLYCOSYL_HYDROL_F31_1; 1.
DR   PROSITE; PS00707; GLYCOSYL_HYDROL_F31_2; 1.
DR   PROSITE; PS51448; P_TREFOIL_2; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Glycosidase {ECO:0000256|RuleBase:RU361185};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361185};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:A0A8M1RH12};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        50..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          99..153
FT                   /note="P-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51448"
FT   REGION          79..103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..101
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   956 AA;  107970 MW;  D5BE50DE95ADD4C6 CRC64;
     MVSYERLTPE EVHFSGAALL DNDESTDADL KEGDPELPLL PQSPRCSITA ALLTLGGLIV
     VLSAVWLLGT LFWIHNPPST ESHRPPSPKS QNGTGLQPES CSQVPEGWRF DCYPERNVVV
     TEDMCHARNC CFIQSSRGNV SAQNGVPWCF YTPDYPSYEL MSIVDTEMGK VGKLLRNKKT
     YYPKDIDALQ LEVLFEEDHR LRVKITDPTE KRYEVPIDVP VVHKRASNPS YTVDFIKEPF
     GLIVKRTQTG AVLLNTSIAP LFYADQFLQM SSSLPTRFIY GLGEHRSNFL HDVQWNTLTM
     WARDVPPMEL TNLYGVHPFY LSMESDGNAH GFFMLNSNAM DVVLQPAPAV TWRMIGGILD
     FYIFLGPDPS SVIGQYLDVV GKPAMPIYWA LGYHLCRWGY KTSNKTWSVV KEMRNYGIPQ
     DVQWNDIDYM DRSLDFTYDP SGFSTLPDLV KDLQRHDQHY VMILDPGISN SQPPGSYWPF
     DEGKKKGIFI NDSNGDILIG KVWPGLTAFP DFSNPDTHEW WYQNLQRFHN KVPFDGVWID
     MNEPSNFFDG SLNGCPDNEL ENPPYTPGIL GGTLKGKTVC ASARQKISVH YNIHSLYGLM
     EAQATESALR RITKKRPFII SRSTFPSQGK YSGHWLGDNR SQWKDLATSI PGMLTFNILG
     IPLIGADICG FGGSTTEELC VRWTQLGAFY PFTRNHNSID EQDQEPTAFS PAARTAMKEA
     ILLRYSLFPH LYTLFHHAHV SGHTVATPLL FQFPTDEKTY GIDKQFLWGK SLLVTPVLDA
     GRDYVVGYFP KGLWYDFHTG NSLISSGEEI KLEAPADKIN LHLREGSVIP TQRPNTTLWV
     SSGQPLHLIV SLSEDGRAKG DLYWDDGETI DSYESNQYAY IYFTVEQNTM MSEVLHNHEE
     ATYITVETAS FYGVKAKPEN VTVNSQEAAF TYLDNQVLTV TDLGLNLSHN FTISWM
//