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Protein

UbiA prenyltransferase domain-containing protein 1

Gene

ubiad1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays a important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from nos3/eNOS-dependent oxidative stress.2 Publications

Pathwayi: menaquinone biosynthesis

This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

  • antioxidant activity Source: UniProtKB
  • nitric-oxide synthase activity Source: ZFIN
  • prenyltransferase activity Source: UniProtKB

GO - Biological processi

  • cardiovascular system development Source: UniProtKB
  • cellular response to fluid shear stress Source: ZFIN
  • endothelial cell development Source: UniProtKB
  • menaquinone biosynthetic process Source: UniProtKB
  • ubiquinone biosynthetic process Source: UniProtKB
  • ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate Source: ZFIN
  • vitamin K biosynthetic process Source: UniProtKB

Keywordsi

Molecular functionPrenyltransferase, Transferase
Biological processMenaquinone biosynthesis, Ubiquinone biosynthesis

Enzyme and pathway databases

ReactomeiR-DRE-6806664 Metabolism of vitamin K
UniPathwayiUPA00079
UPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
UbiA prenyltransferase domain-containing protein 1 (EC:2.5.1.-)
Alternative name(s):
Protein barolo
Protein reddish
Gene namesi
Name:ubiad1
Synonyms:bar, reh
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-030131-3205 ubiad1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Transmembranei254 – 274HelicalSequence analysisAdd BLAST21
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Cranial vascular hemorrhages and pericardial edema, leading to complete cardiac and vascular organ failure by 72 hpf. Defects are due to increased oxidative stress.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi65L → Q in reh(S587); cranial vascular hemmorhages in multiple areas of the head, leading to death by 72 hpf. 1 Publication1
Mutagenesisi82L → Q in bar(S847); increased oxidative stress, DNA damage and cell death specifically in blood vessels and the heart. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004225981 – 336UbiA prenyltransferase domain-containing protein 1Add BLAST336

Proteomic databases

PaxDbiE7FB98

Expressioni

Developmental stagei

Ubiquitous expression at 24 hours post fertilization (hpf) in addition to a distinct expression in the heart at 48 hpf.1 Publication

Gene expression databases

BgeeiENSDARG00000013009

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000012519

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4581 Eukaryota
COG1575 LUCA
GeneTreeiENSGT00390000012439
InParanoidiE7FB98
OMAiPPMYSVA
OrthoDBiEOG091G0C2Z
PhylomeDBiE7FB98
TreeFamiTF323238

Family and domain databases

InterProiView protein in InterPro
IPR000537 UbiA_prenyltransferase
IPR026046 UBIAD1
PfamiView protein in Pfam
PF01040 UbiA, 1 hit
PIRSFiPIRSF005355 UBIAD1, 1 hit

Sequencei

Sequence statusi: Complete.

E7FB98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEMKPAALS GSNGLNGASG SSVRVPCSRL SRAGRMALDL QSKCAAYVLA
60 70 80 90 100
LRPWSFSASL TPVALGSALA YKLEGSVDLL LLLVCAVAVL LVHGAGNLVN
110 120 130 140 150
TYYDFSKGID HKKSDDRTLV DQILKPQDVV MFGAVLYSAG CLCATLLYFL
160 170 180 190 200
SSLKLEHLAL IYFGGLSSSF LYTGGIGLKY VALGDVVILI TFGPLAVMFA
210 220 230 240 250
HAVQVGYLSV LPLVYAVPLA LNTEAILHSN NTRDMDSDKQ AGIVTLAILL
260 270 280 290 300
GPTLSYVIYN LLLFVPYLLF CILATRYTIS MALPLLTLPM AFPLERQFRC
310 320 330
RCYAKIPQKT AKLNLLMGLF YVFGIILAPQ GSLPLL
Length:336
Mass (Da):36,214
Last modified:March 8, 2011 - v1
Checksum:i89D81FC22405AF35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABZ01068151 Genomic DNA No translation available.
RefSeqiNP_001186655.1, NM_001199726.3
UniGeneiDr.78772

Genome annotation databases

EnsembliENSDART00000015554; ENSDARP00000012519; ENSDARG00000013009
GeneIDi558410
KEGGidre:558410

Similar proteinsi

Entry informationi

Entry nameiUBIA1_DANRE
AccessioniPrimary (citable) accession number: E7FB98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2013
Last sequence update: March 8, 2011
Last modified: February 28, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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