ID   E7F8R4_DANRE            Unreviewed;       341 AA.
AC   E7F8R4; A0A8M1NA41;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 2.
DT   27-MAR-2024, entry version 96.
DE   RecName: Full=Arginase {ECO:0000256|ARBA:ARBA00012168, ECO:0000256|RuleBase:RU361159};
DE            EC=3.5.3.1 {ECO:0000256|ARBA:ARBA00012168, ECO:0000256|RuleBase:RU361159};
GN   Name=arg1 {ECO:0000313|Ensembl:ENSDARP00000097045,
GN   ECO:0000313|RefSeq:NP_001038662.1,
GN   ECO:0000313|ZFIN:ZDB-GENE-040724-181};
GN   Synonyms=si:ch211-146f4.3 {ECO:0000313|RefSeq:NP_001038662.1},
GN   SI:zC146F4.4 {ECO:0000313|RefSeq:NP_001038662.1}, zC146F4.3
GN   {ECO:0000313|RefSeq:NP_001038662.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000097045};
RN   [1] {ECO:0000313|RefSeq:NP_001038662.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038662.1};
RX   PubMed=21179501;
RA   Feng Y., Santoriello C., Mione M., Hurlstone A., Martin P.;
RT   "Live imaging of innate immune cell sensing of transformed cells in
RT   zebrafish larvae: parallels between tumor initiation and wound
RT   inflammation.";
RL   PLoS Biol. 8:e1000562-e1000562(2010).
RN   [2] {ECO:0000313|RefSeq:NP_001038662.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038662.1};
RX   PubMed=21379331; DOI=10.1371/journal.pgen.1001310;
RA   Veth K.N., Willer J.R., Collery R.F., Gray M.P., Willer G.B., Wagner D.S.,
RA   Mullins M.C., Udvadia A.J., Smith R.S., John S.W., Gregg R.G., Link B.A.;
RT   "Mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that
RT   models myopia and other risk factors for glaucoma.";
RL   PLoS Genet. 7:e1001310-e1001310(2011).
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000097045}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000097045};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0000313|Ensembl:ENSDARP00000097045, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000097045};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RG   Genome Reference Consortium Zebrafish;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA   Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA   Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA   Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA   Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA   Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA   Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA   Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA   Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA   Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA   Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA   Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA   Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA   Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA   Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA   Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA   Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA   Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA   Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA   Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [5] {ECO:0000313|RefSeq:NP_001038662.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038662.1};
RX   PubMed=24465614; DOI=10.1371/journal.pone.0085597;
RA   Caldovic L., Haskins N., Mumo A., Majumdar H., Pinter M., Tuchman M.,
RA   Krufka A.;
RT   "Expression pattern and biochemical properties of zebrafish N-
RT   acetylglutamate synthase.";
RL   PLoS ONE 9:E85597-E85597(2014).
RN   [6] {ECO:0000313|RefSeq:NP_001038662.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038662.1};
RX   PubMed=26154973;
RA   Nguyen-Chi M., Laplace-Builhe B., Travnickova J., Luz-Crawford P.,
RA   Tejedor G., Phan Q.T., Duroux-Richard I., Levraud J.P., Kissa K.,
RA   Lutfalla G., Jorgensen C., Djouad F.;
RT   "Identification of polarized macrophage subsets in zebrafish.";
RL   Elife 4:e07288-e07288(2015).
RN   [7] {ECO:0000313|RefSeq:NP_001038662.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038662.1};
RX   PubMed=27189481;
RA   Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA   Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA   Bobe J.;
RT   "Gene evolution and gene expression after whole genome duplication in fish:
RT   the PhyloFish database.";
RL   BMC Genomics 17:368-368(2016).
RN   [8] {ECO:0000313|RefSeq:NP_001038662.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038662.1};
RX   PubMed=28962522;
RA   Vliegenthart A.D.B., Wei C., Buckley C., Berends C., de Potter C.M.J.,
RA   Schneemann S., Del Pozo J., Tucker C., Mullins J.J., Webb D.J., Dear J.W.;
RT   "Characterization of Triptolide-Induced Hepatotoxicity by Imaging and
RT   Transcriptomics in a Novel Zebrafish Model.";
RL   Toxicol. Sci. 159:380-391(2017).
RN   [9] {ECO:0000313|RefSeq:NP_001038662.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038662.1};
RX   PubMed=29208761; DOI=10.1242/dmm.031658;
RA   Luukinen H., Hammaren M.M., Vanha-Aho L.M., Svorjova A., Kantanen L.,
RA   Jarvinen S., Luukinen B.V., Dufour E., Ramet M., Hytonen V.P., Parikka M.;
RT   "Priming of innate antimycobacterial immunity by heat-killed Listeria
RT   monocytogenes induces sterilizing response in the adult zebrafish
RT   tuberculosis model. .";
RL   Dis. Model. Mech. 11:dmm031658-dmm031658(2018).
RN   [10] {ECO:0000313|RefSeq:NP_001038662.1}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038662.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-arginine = L-ornithine + urea; Xref=Rhea:RHEA:20569,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:16199, ChEBI:CHEBI:32682,
CC         ChEBI:CHEBI:46911; EC=3.5.3.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000227,
CC         ECO:0000256|RuleBase:RU361159};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|RuleBase:RU361159};
CC       Note=Binds 2 manganese ions per subunit.
CC       {ECO:0000256|RuleBase:RU361159};
CC   -!- PATHWAY: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-
CC       arginine: step 1/1. {ECO:0000256|ARBA:ARBA00005098,
CC       ECO:0000256|RuleBase:RU361159}.
CC   -!- SIMILARITY: Belongs to the arginase family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00742, ECO:0000256|RuleBase:RU003684}.
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DR   EMBL; AL732629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001038662.1; NM_001045197.1.
DR   STRING; 7955.ENSDARP00000097045; -.
DR   PaxDb; 7955-ENSDARP00000074552; -.
DR   PeptideAtlas; E7F8R4; -.
DR   Ensembl; ENSDART00000106267; ENSDARP00000097045; ENSDARG00000057429.
DR   Ensembl; ENSDART00000106267.5; ENSDARP00000097045.3; ENSDARG00000057429.6.
DR   GeneID; 570368; -.
DR   KEGG; dre:570368; -.
DR   AGR; ZFIN:ZDB-GENE-040724-181; -.
DR   CTD; 383; -.
DR   ZFIN; ZDB-GENE-040724-181; arg1.
DR   eggNOG; KOG2965; Eukaryota.
DR   HOGENOM; CLU_039478_6_1_1; -.
DR   OMA; YAMDSID; -.
DR   OrthoDB; 161483at2759; -.
DR   PhylomeDB; E7F8R4; -.
DR   TreeFam; TF300034; -.
DR   Reactome; R-DRE-6798695; Neutrophil degranulation.
DR   Reactome; R-DRE-70635; Urea cycle.
DR   UniPathway; UPA00158; UER00270.
DR   PRO; PR:E7F8R4; -.
DR   Proteomes; UP000000437; Alternate scaffold 12.
DR   Proteomes; UP000000437; Chromosome 12.
DR   Bgee; ENSDARG00000057429; Expressed in bone element and 9 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004053; F:arginase activity; IBA:GO_Central.
DR   GO; GO:0030145; F:manganese ion binding; IBA:GO_Central.
DR   GO; GO:0019547; P:arginine catabolic process to ornithine; IBA:GO_Central.
DR   GO; GO:0000050; P:urea cycle; IEA:UniProtKB-UniPathway.
DR   CDD; cd09989; Arginase; 1.
DR   Gene3D; 3.40.800.10; Ureohydrolase domain; 1.
DR   InterPro; IPR014033; Arginase.
DR   InterPro; IPR006035; Ureohydrolase.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   InterPro; IPR020855; Ureohydrolase_Mn_BS.
DR   NCBIfam; TIGR01229; rocF_arginase; 1.
DR   PANTHER; PTHR43782; ARGINASE; 1.
DR   PANTHER; PTHR43782:SF2; ARGINASE-1; 1.
DR   Pfam; PF00491; Arginase; 1.
DR   PIRSF; PIRSF036979; Arginase; 1.
DR   PRINTS; PR00116; ARGINASE.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 1.
DR   PROSITE; PS01053; ARGINASE_1; 1.
DR   PROSITE; PS51409; ARGINASE_2; 1.
PE   1: Evidence at protein level;
KW   Arginine metabolism {ECO:0000256|ARBA:ARBA00022503,
KW   ECO:0000256|RuleBase:RU361159};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003684};
KW   Manganese {ECO:0000256|RuleBase:RU361159};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361159};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:E7F8R4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Urea cycle {ECO:0000256|ARBA:ARBA00022436, ECO:0000256|RuleBase:RU361159}.
SQ   SEQUENCE   341 AA;  37241 MW;  E84E6E2840760D6F CRC64;
     MMKMKSLSGS RAALHIFRRH LHHQRYSVGI IGAPFSKGQQ KDGVQEGADL IRAAGLVQKL
     KGQGCVVKDY GNVTFENLPN DESIGRLKTP RAVGRANELL SGAVQKIKSD GNTCVMLGGD
     HSLAIGSISG HAAYRHELSV LWVDAHADIN TPLTTPTGNI HGQPMSYLIH ELHSKMPKLP
     NFSWLKPCIA AQDVVYIGLR DVDPEEHYIL KYLGIKTFSM TEVDRLGIAK VMEQTCDHMF
     SKVKKPIHLS FDIDALDPSV SPATGTPVAG GLTYREGIYI TEHICQTGLL SAVDMVEVNP
     KLGRTADEIK STVNAAVDLL LGCFGRIREG SHDPDYKMPN P
//