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Protein

Arginase

Gene

arg1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Pathwayi: urea cycle

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine and urea from L-arginine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Arginase (arg1), Arginase (arg2)
This subpathway is part of the pathway urea cycle, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine and urea from L-arginine, the pathway urea cycle and in Nitrogen metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processArginine metabolismUniRule annotation, Urea cycleUniRule annotation
LigandManganeseUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-6798695. Neutrophil degranulation.
R-DRE-70635. Urea cycle.
UniPathwayiUPA00158; UER00270.

Names & Taxonomyi

Protein namesi
Recommended name:
ArginaseUniRule annotation (EC:3.5.3.1UniRule annotation)
Gene namesi
Name:arg1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 12

Organism-specific databases

ZFINiZDB-GENE-040724-181. arg1.

PTM / Processingi

Proteomic databases

PaxDbiE7F8R4.
PeptideAtlasiE7F8R4.

Expressioni

Gene expression databases

BgeeiENSDARG00000057429.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000074552.

Structurei

3D structure databases

ProteinModelPortaliE7F8R4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2965. Eukaryota.
COG0010. LUCA.
GeneTreeiENSGT00530000063082.
InParanoidiE7F8R4.
KOiK01476.
OMAiEQECDVK.
OrthoDBiEOG091G0A38.
PhylomeDBiE7F8R4.
TreeFamiTF300034.

Family and domain databases

InterProiView protein in InterPro
IPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR020855. Ureohydrolase_Mn_BS.
PfamiView protein in Pfam
PF00491. Arginase. 1 hit.
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiView protein in PROSITE
PS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

E7F8R4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKMKSLSGS RAALHIFRRH LHHQRYSVGI IGAPFSKGQQ KDGVQEGADL
60 70 80 90 100
IRAAGLVQKL KGQGCVVKDY GNVTFENLPN DESIGRLKTP RAVGRANELL
110 120 130 140 150
SGAVQKIKSD GNTCVMLGGD HSLAIGSISG HAAYRHELSV LWVDAHADIN
160 170 180 190 200
TPLTTPTGNI HGQPMSYLIH ELHSKMPKLP NFSWLKPCIA AQDVVYIGLR
210 220 230 240 250
DVDPEEHYIL KYLGIKTFSM TEVDRLGIAK VMEQTCDHMF SKVKKPIHLS
260 270 280 290 300
FDIDALDPSV SPATGTPVAG GLTYREGIYI TEHICQTGLL SAVDMVEVNP
310 320 330 340
KLGRTADEIK STVNAAVDLL LGCFGRIREG SHDPDYKMPN P
Length:341
Mass (Da):37,241
Last modified:January 20, 2016 - v2
Checksum:iE84E6E2840760D6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732629 Genomic DNA. No translation available.
RefSeqiNP_001038662.1. NM_001045197.1.
UniGeneiDr.151956.

Genome annotation databases

EnsembliENSDART00000106267; ENSDARP00000097045; ENSDARG00000057429.
GeneIDi570368.
KEGGidre:570368.

Similar proteinsi

Entry informationi

Entry nameiE7F8R4_DANRE
AccessioniPrimary (citable) accession number: E7F8R4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: January 20, 2016
Last modified: September 27, 2017
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported