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Protein

Arginase

Gene

arg1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Pathwayi: urea cycle

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine and urea from L-arginine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Arginase (arg1), Arginase (arg2)
This subpathway is part of the pathway urea cycle, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine and urea from L-arginine, the pathway urea cycle and in Nitrogen metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Arginine metabolismUniRule annotation, Urea cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-70635. Urea cycle.
UniPathwayiUPA00158; UER00270.

Names & Taxonomyi

Protein namesi
Recommended name:
ArginaseUniRule annotation (EC:3.5.3.1UniRule annotation)
Gene namesi
Name:arg1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 12

Organism-specific databases

ZFINiZDB-GENE-040724-181. arg1.

PTM / Processingi

Proteomic databases

PaxDbiE7F8R4.
PeptideAtlasiE7F8R4.

Expressioni

Gene expression databases

BgeeiENSDARG00000057429.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000097045.

Structurei

3D structure databases

ProteinModelPortaliE7F8R4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2965. Eukaryota.
COG0010. LUCA.
GeneTreeiENSGT00530000063082.
InParanoidiE7F8R4.
KOiK01476.
OMAiEQECDVK.
OrthoDBiEOG091G0A38.
PhylomeDBiE7F8R4.
TreeFamiTF300034.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E7F8R4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKMKSLSGS RAALHIFRRH LHHQRYSVGI IGAPFSKGQQ KDGVQEGADL
60 70 80 90 100
IRAAGLVQKL KGQGCVVKDY GNVTFENLPN DESIGRLKTP RAVGRANELL
110 120 130 140 150
SGAVQKIKSD GNTCVMLGGD HSLAIGSISG HAAYRHELSV LWVDAHADIN
160 170 180 190 200
TPLTTPTGNI HGQPMSYLIH ELHSKMPKLP NFSWLKPCIA AQDVVYIGLR
210 220 230 240 250
DVDPEEHYIL KYLGIKTFSM TEVDRLGIAK VMEQTCDHMF SKVKKPIHLS
260 270 280 290 300
FDIDALDPSV SPATGTPVAG GLTYREGIYI TEHICQTGLL SAVDMVEVNP
310 320 330 340
KLGRTADEIK STVNAAVDLL LGCFGRIREG SHDPDYKMPN P
Length:341
Mass (Da):37,241
Last modified:January 20, 2016 - v2
Checksum:iE84E6E2840760D6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732629 Genomic DNA. No translation available.
RefSeqiNP_001038662.1. NM_001045197.1.
UniGeneiDr.151956.

Genome annotation databases

EnsembliENSDART00000106267; ENSDARP00000097045; ENSDARG00000057429.
GeneIDi570368.
KEGGidre:570368.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732629 Genomic DNA. No translation available.
RefSeqiNP_001038662.1. NM_001045197.1.
UniGeneiDr.151956.

3D structure databases

ProteinModelPortaliE7F8R4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000097045.

Proteomic databases

PaxDbiE7F8R4.
PeptideAtlasiE7F8R4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000106267; ENSDARP00000097045; ENSDARG00000057429.
GeneIDi570368.
KEGGidre:570368.

Organism-specific databases

CTDi383.
ZFINiZDB-GENE-040724-181. arg1.

Phylogenomic databases

eggNOGiKOG2965. Eukaryota.
COG0010. LUCA.
GeneTreeiENSGT00530000063082.
InParanoidiE7F8R4.
KOiK01476.
OMAiEQECDVK.
OrthoDBiEOG091G0A38.
PhylomeDBiE7F8R4.
TreeFamiTF300034.

Enzyme and pathway databases

UniPathwayiUPA00158; UER00270.
ReactomeiR-DRE-70635. Urea cycle.

Miscellaneous databases

PROiE7F8R4.

Gene expression databases

BgeeiENSDARG00000057429.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE7F8R4_DANRE
AccessioniPrimary (citable) accession number: E7F8R4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: January 20, 2016
Last modified: September 7, 2016
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.