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E7F8R4

- E7F8R4_DANRE

UniProt

E7F8R4 - E7F8R4_DANRE

Protein

Arginase

Gene

LOC100148378

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-arginine + H2O = L-ornithine + urea.UniRule annotation

    Cofactori

    Binds 2 manganese ions per subunit.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. arginase activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginine metabolic process Source: InterPro

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Keywords - Biological processi

    Arginine metabolismUniRule annotation, Urea cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00158; UER00270.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ArginaseUniRule annotation (EC:3.5.3.1UniRule annotation)
    Gene namesi
    Name:LOC100148378Imported
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 12

    Expressioni

    Gene expression databases

    BgeeiE7F8R4.

    Structurei

    3D structure databases

    ProteinModelPortaliE7F8R4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the arginase family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00530000063082.
    KOiK01476.
    OMAiNHAKEGK.
    OrthoDBiEOG747PJ5.
    PhylomeDBiE7F8R4.
    TreeFamiTF300034.

    Family and domain databases

    Gene3Di3.40.800.10. 1 hit.
    InterProiIPR014033. Arginase.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view]
    PANTHERiPTHR11358. PTHR11358. 1 hit.
    PfamiPF00491. Arginase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036979. Arginase. 1 hit.
    PRINTSiPR00116. ARGINASE.
    TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
    PROSITEiPS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E7F8R4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMKMKSFSGS RAALHIFRRH LHHQRHSVGI IGAPFSKGQQ KDGVQEGADL    50
    IRAAGLVQKL KGQGCVVKDY GNVTFENLPN DESIGRLKTP RAVGRANELL 100
    SGAVQKIKSD GNTCVMLGGD HSLAIGSISG HAASGHELSV LWVDAHADIN 150
    TPLTTPTGNI HGQPMSYLIH ELHSKMPKLP NFSWLKPCVA AQDVVYIGLR 200
    DVDPEEHYIL KYLGIKTFSM TEVDRLGIAK VMEQTCDHMF SKVKKPIHLS 250
    FDIDALDPAV SPATGTPVAG GLTYREGIYI TEHICQTGLL SAVDMVEVNP 300
    KLGRTADEIK STVNAAVDLL LGCFGRIREG SHDPDYKMPN P 341
    Length:341
    Mass (Da):37,044
    Last modified:March 8, 2011 - v1
    Checksum:i42953EB203BCA7AA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX000466 Genomic DNA. No translation available.
    RefSeqiXP_001922598.1. XM_001922563.3.

    Genome annotation databases

    EnsembliENSDART00000106267; ENSDARP00000097045; ENSDARG00000057429.
    GeneIDi100148378.
    KEGGidre:100148378.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX000466 Genomic DNA. No translation available.
    RefSeqi XP_001922598.1. XM_001922563.3.

    3D structure databases

    ProteinModelPortali E7F8R4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000106267 ; ENSDARP00000097045 ; ENSDARG00000057429 .
    GeneIDi 100148378.
    KEGGi dre:100148378.

    Phylogenomic databases

    GeneTreei ENSGT00530000063082.
    KOi K01476.
    OMAi NHAKEGK.
    OrthoDBi EOG747PJ5.
    PhylomeDBi E7F8R4.
    TreeFami TF300034.

    Enzyme and pathway databases

    UniPathwayi UPA00158 ; UER00270 .

    Miscellaneous databases

    NextBioi 20792006.
    PROi E7F8R4.

    Gene expression databases

    Bgeei E7F8R4.

    Family and domain databases

    Gene3Di 3.40.800.10. 1 hit.
    InterProi IPR014033. Arginase.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view ]
    PANTHERi PTHR11358. PTHR11358. 1 hit.
    Pfami PF00491. Arginase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036979. Arginase. 1 hit.
    PRINTSi PR00116. ARGINASE.
    TIGRFAMsi TIGR01229. rocF_arginase. 1 hit.
    PROSITEi PS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genomic sequence of Danio rerio."
      The Danio rerio Sequencing Project at the Sanger Institute
      Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TuebingenImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: TuebingenImported.
    3. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TuebingenImported.

    Entry informationi

    Entry nameiE7F8R4_DANRE
    AccessioniPrimary (citable) accession number: E7F8R4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 8, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3