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Protein
Submitted name:

Neurotrophin receptor-associated death domain

Gene

nradd

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Neurotrophin receptor-associated death domainImported
Gene namesi
Name:nraddImported
Synonyms:ngfrImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 16

Organism-specific databases

ZFINiZDB-GENE-030131-2537. nradd.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500321765123 – 413Sequence analysisAdd BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi60 ↔ 75PROSITE-ProRule annotation
Disulfide bondi78 ↔ 91PROSITE-ProRule annotation
Disulfide bondi81 ↔ 99PROSITE-ProRule annotation
Disulfide bondi121 ↔ 134PROSITE-ProRule annotation
Disulfide bondi124 ↔ 142PROSITE-ProRule annotation
Disulfide bondi145 ↔ 160PROSITE-ProRule annotation
Disulfide bondi163 ↔ 176PROSITE-ProRule annotation
Disulfide bondi166 ↔ 184PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

PaxDbiE7F8D4.
PeptideAtlasiE7F8D4.
PRIDEiE7F8D4.

Expressioni

Gene expression databases

BgeeiENSDARG00000057143.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000002813.

Structurei

3D structure databases

ProteinModelPortaliE7F8D4.
SMRiE7F8D4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 99TNFR-CysInterPro annotationAdd BLAST41
Repeati59 – 99TNFR-CysPROSITE-ProRule annotationAdd BLAST41
Domaini100 – 142TNFR-CysInterPro annotationAdd BLAST43
Repeati100 – 142TNFR-CysPROSITE-ProRule annotationAdd BLAST43
Domaini144 – 184TNFR-CysInterPro annotationAdd BLAST41
Repeati144 – 184TNFR-CysPROSITE-ProRule annotationAdd BLAST41
Domaini344 – 407DeathInterPro annotationAdd BLAST64

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IQFC. Eukaryota.
ENOG4111F3C. LUCA.
GeneTreeiENSGT00730000110974.
InParanoidiE7F8D4.
KOiK02583.
OMAiYVAYKCW.
OrthoDBiEOG091G0M0X.
PhylomeDBiE7F8D4.
TreeFamiTF106466.

Family and domain databases

CDDicd13416. TNFRSF16. 1 hit.
InterProiView protein in InterPro
IPR011029. DEATH-like_dom_sf.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR034046. TNFRSF16_N.
PfamiView protein in Pfam
PF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
SMARTiView protein in SMART
SM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiView protein in PROSITE
PS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 3 hits.

Sequencei

Sequence statusi: Complete.

E7F8D4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGATEALQL CFYVLAVKMA FGKTCTSEQF TKTGECCSMC AAGTGLVTSC
60 70 80 90 100
GQEDTKCQPC QDGVSFSDSE SLLSCTLCAH CPIGIPQLAR CTKTQDTRCD
110 120 130 140 150
CGEHFFLWRD GNSTGGLCAP CRKCGPGWGV SQACGLLGDT KCELCKPGTY
160 170 180 190 200
SKDTSDRKPC VPCSRCQDEE VEIRPCLPDS DTVCMVKDLN ILSRPSGSDG
210 220 230 240 250
PRETPRLQTP NEETESGISP APGSGAPRLT PQDQGGNNNI LVYVSVLAAV
260 270 280 290 300
VLGLLLYVAY KCWKSCQQKQ ALVKARVGEL NNAGEGEKLH SDSGVFLDSH
310 320 330 340 350
SLQESQPSKG SKRDSKQDTR LYINLPPHRQ EEVEGLLAEG GNRSWKQLAA
360 370 380 390 400
TLGYEQERVD VFGRGQDPIH TLMTDWSQQE GSTLGLLCSA LTRIERPDII
410
TALTAPTQGV SVV
Length:413
Mass (Da):44,462
Last modified:March 8, 2011 - v1
Checksum:i35BAD54937808605
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU138519 Genomic DNA. No translation available.
RefSeqiXP_700985.3. XM_695893.7.
UniGeneiDr.105435.
Dr.72875.

Genome annotation databases

EnsembliENSDART00000022685; ENSDARP00000002813; ENSDARG00000057143.
GeneIDi572204.
KEGGidre:572204.

Similar proteinsi

Entry informationi

Entry nameiE7F8D4_DANRE
AccessioniPrimary (citable) accession number: E7F8D4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: March 28, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported